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Cardiovascular risk markers not helped by 20,000 IU of vitamin D weekly – RCT May 2018

Vitamin D supplementation does not improve CVD risk factors in vitamin D insufficient subjects.

Endocr Connect. 2018 May 15. pii: EC-18-0144. doi: 10.1530/EC-18-0144. [Epub ahead of print]
Kubiak JM1, Thorsby PM2, Kamycheva E3, Jorde R4.


Study supplemented those with low vitamin D with 20,000 IU weekly for just 4 months
   20,000 IU weekly = 2,900 IU daily
Many studies are recommending that everyone needs at least 4,000 IU daily for health

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Some interesting Hypertension studies

 Download the PDF from VitaminDWiki

Low serum 25(OH)D levels are associated with cardiovascular disease (CVD) and some of its risk factors. However, in interventional studies the effects of vitamin D supplementation have been uncertain, possibly due to inclusion of vitamin D sufficient subjects. Our aim was therefore to examine effects of vitamin D supplementation on CVD risk factors in vitamin D insufficient subjects.

DESIGN: Double-blinded randomized controlled trial.

METHODS: A four months interventional study with high dose vitamin D (100 000 IU loading dose, followed by 20 000 IU/week) or placebo with measurements of:

  • blood pressure,
  • lipids (total-, LDL- and HDL-cholesterol, triglycerides, apolipoproteins A1 and B ), and
  • glucose metabolism parameters
    (blood glucose,HbA1c, sRAGE (minor improvement), insulin, C-peptide, and HOMA-IR).

422 subjects with mean serum 25(OH)D level 34 nmol/L were included, with 411 subjects completing the study. Serum 25(OH)D levels increased with 56 nmol/L and decreased with 4 nmol/L in the vitamin D and placebo group, respectively. We found no statistically significant differences between the two groups in any of the measured CVD risk factors, except for a minor increase in sRAGE in the vitamin D group.
Stratified analyses of subjects with low baseline serum 25(OH)D levels alone, or combined with blood pressure, lipid and HOMA-IR values above the median for the cohort, did not skew the results in favour of vitamin D supplementation.

CONCLUSION: Supplementation with vitamin D in subjects with baseline vitamin D insufficiency does not improve CVD risk factors profile.

PMID: 29764903 DOI: 10.1530/EC-18-0144

Created by admin. Last Modification: Monday September 10, 2018 14:03:15 GMT-0000 by admin. (Version 6)

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