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Cardiovascular problems for teens if low levels of vitamin D – March 2012

Circulating 25-Hydroxyvitamin D Concentrations Are Correlated With Cardiometabolic Risk Among American Black and White Adolescents Living in a Year-Round Sunny Climate.

Diabetes Care. 2012 Mar 12.
Parikh S, Guo DH, Pollock NK, Petty K, Bhagatwala J, Gutin B, Houk C, Zhu H, Dong Y.
Internal Medicine, Department of Medicine, Georgia Health Sciences University, Augusta, Georgia.

OBJECTIVE: Low vitamin D status is common among healthy black and white adolescents residing at southern U.S. latitudes with a year-round sunny climate.
Thus we aimed to study the relationships between circulating 25-hydroxyvitamin D 25(OH)D and cardiometabolic risk factors in this population.

RESEARCH DESIGN AND METHODS: 25(OH)D concentrations were measured with liquid chromatography tandem mass spectroscopy in 701 girls and boys (14-18 years old, 54% blacks, 49% females). Cardiometabolic risk was indexed by adipokines, inflammatory markers, fasting glucose, homeostatic model assessment-insulin resistance (HOMA-IR), lipid profile, and blood pressures (BP).

RESULTS: Controlling for age, sex, race, sexual maturation, season, physical activity, and percent body fat, 25(OH)D concentrations were significantly correlated with adiponectin (r = 0.06, P = 0.05), leptin (r = -0.32, P < 0.01), fibrinogen (r = -0.05, P = 0.03), glucose (r = -0.16, P = 0.02), HOMA-IR (r = -0.17, P < 0.01), HDL cholesterol (r = 0.14, P = 0.02), systolic BP (r = -0.10, P = 0.02), and diastolic BP (r = -0.21, P < 0.01).

When 25(OH)D concentrations were stratified into increasing tertiles, there were significant linear upward trends for

  • adiponectin (P = 0.01) and *

HDL cholesterol (P = 0.04),
but significant linear down trends for

  • glucose (P < 0.01),
  • HOMA-IR (P < 0.01), and
  • systolic BP (P < 0.01),

after adjusting for the above covariates.

CONCLUSIONS: Circulating 25(OH)D concentrations are associated with various adverse cardiometabolic risk factors, independent of adiposity.
Clinical trials addressing the effects of vitamin D supplementation on cardiometabolic risk are warranted in adolescents irrespective of their geographical regions.

PMID: 22410810
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