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Cardiovascular disease is treated by vitamin D, unsure if low Vit D can predict Cardio – Sept 2018

Vitamin D in Cardiovascular Disease

In Vivo September-October 2018 vol. 32 no. 5 977-981, 10.21873/invivo.11338
ALKIPPI NITSA1,2, MARINA TOUTOUZA2, NIKOLAOS MACHAIRAS1, ANARGYROS MARIOLIS3, ANASTASSIOS PHILIPPOU1 and MICHAEL KOUTSILIERIS1 mkoutsil at med.uoa.gr
1 Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
2 Biochemistry & Microbiology Laboratory, Hipokrateion Hospital, Athens, Greece
3 Health Center, National Health System, Areopolis, Greece

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Cardiovascular category starts with the following

439 items In Cardiovascular category

Meta-analyses (auto-updated)

Omega-3 Helps (auto-updated)

A poor Vitamin D Receptor can block Vitamin D in blood from getting to tissues

Cholesterol, Statins


Pages listed in BOTH the categories Cardiovascular and Meta-analysis


Pages listed in BOTH the categories Intervention and Cardiovascular

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Cardiovascular disease is the prevalent cause of morbidity and mortality in the world, affecting many millions of individuals every year. Atherosclerosis, a chronic inflammatory condition that involves different cell types, several cytokines and adhesion molecules, is the underlying cause of cardiovascular disease. Vitamin D is known to control skeletal patho/physiology, regulating calcium and phosphorus and bone remodeling along with other calcium-regulating hormones. However, several active metabolites of vitamin D can exert both direct action, mainly via vitamin D3 receptor trans-activation and indirect actions on several other tissues by an endocrine, autocrine and paracrine manners. With regard to cardiovascular disease, vitamin D deficiency has been associated with activation of the pro-inflammatory mechanism, promoting atherogenesis. There are several large-scale clinical studies, as well as meta-analyses that support this finding.

However, it is still unclear whether the plasma 25-hydroxyvitamin D level can be used as a biomarker for future cardiovascular disease. Herein we review the studies reporting a causative role for vitamin D in cardiovascular disease.


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