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Cancer treated better when active vitamin d (calcitriol) is inside of PLGA nanoparticles – June 2015

PLGA nanoparticles as a platform for vitamin D-based cancer therapy

Beilstein J. Nanotechnol. 2015, 6, 1306–1318. doi:10.3762/bjnano.6.135
Maria J. Ramalho, Joana A. Loureiro, Bárbara Gomes, Manuela F. Frasco, Manuel A. N. Coelho and M. Carmo Pereira mcsp at fe.up.pt
LEPABE, Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal

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Poly(lactic-co-glycolic acid) (PLGA) nanoparticles were studied as drug delivery vehicles for calcitriol, the active form of vitamin D3. In vitro effects of calcitriol encapsulated in PLGA nanoparticles were evaluated with respect to free calcitriol on human pancreatic cell lines, S2-013 and hTERT-HPNE, and the lung cancer cell line A549. Encapsulated calcitriol retained its biological activity, reducing the cell growth. Cytotoxicity assays demonstrated that encapsulation of calcitriol enhanced its inhibitory effect on cell growth at a concentration of 2.4 μM for the S2-013 cells (91%) and for A549 cells (70%) comparared to the free calcitriol results. At this concentration the inhibitory effect on nontumor cells (hTERT-HPNE) decreased to 65%. This study highlights the ability of PLGA nanoparticles to deliver vitamin D3 into cancer cells, with major effects regarding cancer cell cycle arrest and major changes in the cell morphological features.

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Attached files

ID Name Comment Uploaded Size Downloads
5609 PLGA.pdf PDF 2015 admin 24 Jun, 2015 18:17 7.72 Mb 648
5608 PLGA F5C.jpg admin 24 Jun, 2015 18:16 22.98 Kb 1171
5607 PLGA F4.jpg admin 24 Jun, 2015 18:15 20.36 Kb 1200
5606 PLGA F2.jpg admin 24 Jun, 2015 18:15 28.06 Kb 1586
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