Toggle Health Problems and D

Cancer deaths strongly related to low vitamin D if sampled near time of diagnosis – Feb 2012

Serum levels of 25-hydroxyvitamin D and survival in Norwegian patients with cancer of breast, colon, lung, and lymphoma: a population-based study.

Cancer Causes Control. 2012 Feb;23(2):363-70. doi: 10.1007/s10552-011-9885-6.
Tretli S1, Schwartz GG, Torjesen PA, Robsahm TE.
1The Cancer Registry of Norway, Institute of Population-based Cancer Research, Majorstuen, 0304 Oslo, Norway. steinar.tretli at kreftregisteret.no

We investigated the association between serum levels of 25-hydroxyvitamin D (25-OHD) and risk of death in Norwegian cancer patients.

The study population was 658 patients with cancers of the breast (n = 251), colon (n = 52), lung (n = 210), and lymphoma (n = 145), obtained from JANUS, a population-based serum bank in Norway. Serum samples were collected within 90 days of cancer diagnosis and were analyzed for 25-OHD. Patients were diagnosed during 1984-2004 and were followed for death throughout 2008. We used Cox regression models to assess the relationship between serum 25-OHD and risk of death.

Three hundred and ninety-nine patients died during follow-up, of whom 343 (86%) died from cancer. Adjusted for sex, age at diagnosis, and season of blood sampling, patients with 25-OHD levels below 46 nmol/L at diagnosis experienced shorter survival. Compared to patients in the lowest quartile of serum 25-OHD, the risk of cancer death among patients in the highest quartile was significantly reduced (HR 0.36 95% CI 0.27, 0.51). The estimated change in risk of cancer death was most pronounced between the first and the second quartile. The associations between 25-OHD levels and survival were observed for all four cancers.

Higher circulating serum levels of 25-OHD were positively associated with the survival for cancers of the breast, colon, lung, and lymphoma.

PMID: 22193397

Image Image

Table 4 Hazard ratio of dying from local versions of any of the cancers

< 46 nmol/L <18.4 ng1.0
46–61 nmol/L 18.4 – 24.6 ng 0.39
62–81 nmol/L24.7– 32.4 ng 0.34
>81 nmol/ > 32.4 ng0.15
Confidence p = 0.06

Table 5 Hazard ratio (HR) and all cause death

  • Number of fatal cases/Number of patients
    • Adjusted for sex, age at diagnosis and season of blood sampling

 Download the PDF from VitaminDWiki

Attached files

ID Name Comment Uploaded Size Downloads
5339 Tretli all cause.jpg admin 18 Apr, 2015 64.66 Kb 1068
5338 Tretli colon breast.jpg admin 18 Apr, 2015 50.63 Kb 1099
5337 Tretli lung lymphoma.jpg admin 18 Apr, 2015 56.03 Kb 1058
5336 Tretli.pdf admin 18 Apr, 2015 237.31 Kb 944