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Calcidiol increased blood levels of Vitamin D in one month (dogs) – Feb 2021

Rapid improvement in vitamin D status with dietary 25-hydroxycholecalciferol in vitamin D insufficient dogs

J Nutr Sci. 2021 Feb 22;10:e12. doi: 10.1017/jns.2021.4
Rachel A Kurzbard 1, Robert C Backus 1, Shiguang Yu 2
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VitaminDWiki

Notes:
1) Dogs were getting Calcitriol 3 times a day (not just once a day like humans)
2) Response might have been faster than a month – levels were only measured monthly
3) Humans also appear to have a fast response to Calcitriol than Vitamin D
4) HyD has been produced by DSM for animals for many decades
5) DSM is starting to produce HyD for humans in 2021
6) HyD = Calcifediol = Calcitriol = semi-activated vitamin D = (25(OH)D) = blood level measurement of Vitmin D

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 Download the PDF from VitaminDWiki

Vitamin D insufficiency is associated with various disease processes. We determined whether consumption of a diet supplemented with HyD®, a 25-hydroxycholecalciferol (25(OH)D3) source, would safely increase plasma 25(OH)D3 concentrations in Golden Retrievers with low vitamin D status. We hypothesised that dietary supplementation with HyD® would rapidly increase and sustain plasma 25(OH)D3 levels in healthy Golden Retrievers with low vitamin D status compared with supplementation with vitamin D3. Of fifty-seven privately owned dogs recruited with written owner consent, eighteen dogs with low vitamin D status were identified and sorted between two groups to have similar initial plasma 25(OH)D3 concentrations, sex distributions, ages and body weights. Dogs of each group were fed a dry dog food supplemented with either 16 μg/kg of 25(OH)D3 as HyD® (n 10) or 81 μg/kg of cholecalciferol (D3) (n 8) for 4 months. Plasma 25(OH)D3 concentrations were determined monthly. A significant time effect (P < 0⋅001) and time by group interaction (P = 0⋅0045) were found for monthly determined plasma 25(OH)D3 concentrations. Dogs fed the HyD®-supplemented diet experienced a 40⋅5 % rise in plasma 25(OH)D3 values after 1 month (P < 0⋅001) and no change thereafter. Plasma 25(OH)D3 values of dogs supplemented with vitamin D3 did not increase (P > 0⋅05) and were less than values of dogs supplemented with HyD® (P = 0⋅044). With few exceptions, average haematologic, biochemical and urinalyses results remained within the reference range for both groups. Dietary supplementation with HyD® is sufficient to safely increase and sustain plasma 25(OH)D3 levels in healthy dogs.


Created by admin. Last Modification: Monday September 13, 2021 20:50:41 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
15491 HyD dogs.jpg admin 24 Apr, 2021 21.31 Kb 448
15490 HyD good for dogs.pdf admin 24 Apr, 2021 427.99 Kb 349