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COVID-19 deaths strongly correlated with percent having less than 10 ng of Vitamin D in a country– July 1 2020

Strong Correlation Between Prevalence of Severe Vitamin D Deficiency and Population Mortality Rate from COVID-19 in Europe

Preprint doi: https://doi.org/10.1101/2020.06.24.20138644
Isaac Z. Pugach, M.D. (Complete Med Care, Dallas, Texas), and
Sofya Pugach, M.D., Ph.D., MPH (Complete Med Care, Dallas, Texas) drpugach at yahoo.com


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Background: SARS-CoV-2 virus causes a very wide range of COVID-19 disease severity in humans: from completely asymptomatic to fatal, and the reasons behind it are often not understood. There is some data that Vitamin D may have protective effect, so authors decided to analyze European country-wide data to determine if Vitamin D levels are associated with COVID-19 population death rate.

Methods: To retrieve the Vitamin D levels data, authors analyzed the Vitamin D European population data compiled by 2019 ECTS Statement on Vitamin D Status published in the European Journal of Endocrinology. For the data set to used for analysis, only recently published data, that included general adult population of both genders ages 40-65 or wider, and must have included the prevalence of Vitamin D deficiency.

Results: There were 10 countries data sets that fit the criteria and were analyzed. Severe Vitamin D deficiency was defined as 25(OH)D less than 25 nmol/L (10 ng/dL). Pearson correlation analysis between death rate per million from COVID-19 and prevalence of severe Vitamin D deficiency shows a strong correlation with r = 0.76, p = 0.01, indicating significant correlation. Correlation remained significant, even after adjusting for age structure of the population. Additionally, over time, correlation strengthened, and r coefficient asymptoticaly increased.

Conclusions: Authors recommend universal screening for Vitamin D deficiency, and further investigation of Vitamin D supplementation in randomized control studies, which may lead to possible treatment or prevention of COVID-19.

Created by admin. Last Modification: Wednesday July 22, 2020 20:24:16 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
13976 10 ng data.jpg admin 01 Jul, 2020 19:46 40.71 Kb 276
13974 Mortality less than 10 ng.jpg admin 01 Jul, 2020 19:40 50.04 Kb 25612
13973 Strong Correlation Vitamin D Deficiency and COVID-19 Mortality - July 1.pdf PDF 2020 admin 01 Jul, 2020 19:40 161.08 Kb 173
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