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COVID-19 and Influenza patients needing ventilation had low Vitamin D – Oct 2021


Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study

BMJ Open 2021;11:e055435. doi:10.1136/bmjopen-2021-055435
Hurst EA, et al, Correspondence to Dr Clark D Russell; clark.russell at ed.ac.uk

COVID-19 patients needing Invasive Mechanical Ventilation had lower Vitamin D

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Influenza patients needing Invasive Mechanical Ventilation had lower Vitamin D

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Objectives The steroid hormone vitamin D has roles in immunomodulation and bone health. Insufficiency is associated with susceptibility to respiratory infections. We report 25-hydroxy vitamin D (25(OH)D) measurements in hospitalised people with COVID-19 and influenza A and in survivors of critical illness to test the hypotheses that vitamin D insufficiency scales with illness severity and persists in survivors.

Design Cross-sectional study.
Setting and participants Plasma was obtained from 295 hospitalised people with COVID-19 (International Severe Acute Respiratory and emerging Infections Consortium (ISARIC)/WHO Clinical Characterization Protocol for Severe Emerging Infections UK study), 93 with influenza A (Mechanisms of Severe Acute Influenza Consortium (MOSAIC) study, during the 2009–2010 H1N1 pandemic) and 139 survivors of non-selected critical illness (prior to the COVID-19 pandemic). Total 25(OH)D was measured by liquid chromatography-tandem mass spectrometry. Free 25(OH)D was measured by ELISA in COVID-19 samples.

Outcome measures Receipt of invasive mechanical ventilation (IMV) and in-hospital mortality.

Results Vitamin D insufficiency (total 25(OH)D 25–50 nmol/L) and deficiency (<25 nmol/L) were prevalent in COVID-19 (29.3% and 44.4%, respectively), influenza A (47.3% and 37.6%) and critical illness survivors (30.2% and 56.8%). In COVID-19 and influenza A, total 25(OH)D measured early in illness was lower in patients who received IMV (19.6 vs 31.9 nmol/L (p<0.0001) and 22.9 vs 31.1 nmol/L (p=0.0009), respectively). In COVID-19, biologically active free 25(OH)D correlated with total 25(OH)D and was lower in patients who received IMV, but was not associated with selected circulating inflammatory mediators.

Conclusions Vitamin D deficiency/insufficiency was present in majority of hospitalised patients with COVID-19 or influenza A and correlated with severity and persisted in critical illness survivors at concentrations expected to disrupt bone metabolism. These findings support early supplementation trials to determine if insufficiency is causal in progression to severe disease, and investigation of longer-term bone health outcomes
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COVID-19 treated by Vitamin D - studies, reports, videos


Overview Influenza and vitamin D

See also Flu update 2018 which has the following
Vitamin D fights all phases of Influenza


VitaminDWiki pages with INFLUENZA of FLU in title

This list is automatcially updated

Items found: 72
Title Modified
COVID, influenza, hepatitis B, measles, etc. vaccine responses vary with Vitamin D and its receptor 14 Nov, 2021
Nursing home vaccinated against Influenza, 800 IU of vitamin D daily cut infection rate in half – small RCT Oct 2021 04 Nov, 2021
COVID-19 and Influenza patients needing ventilation had low Vitamin D – Oct 2021 22 Oct, 2021
Poor Vitamin D receptor blocked Vitamin D from fighting avian influenza viruses (in mice) – July 2021 17 Oct, 2021
US COVID-19 deaths now exceed 1918 flu, soon AIDS (Vitamin D fights all 3) - Sept 19, 2021 22 Sep, 2021
Influenza of 1918 and vitamin D - July 2010 22 Sep, 2021
Vaccines protect for: 10 years Tetanus, 3 years Typhoid, 6 month Influenza, unknown COVID – WSJ Sep 10, 2021 13 Sep, 2021
Vitamin D probably can both prevent Influenza and augment vaccine effectiveness – Aug 2018 18 Aug, 2021
This Vitamin Shown to Be Almost 10 Times More Effective Than the Flu Shot – Feb 2017 18 Aug, 2021
Obese get less benefit from vaccines: influenza, hepatitis B, rabies and now COVID-19 - March 2021 01 Aug, 2021
More than 1 hour of daily sun improved influenza vaccine by 35 percent (Vitamin D helps again) – Oct 2019 28 Jul, 2021
Half of COVID-19 death rate differences explained by rates of elderly influenza vaccination and low vitamin D – April 2021 26 May, 2021
Clear Association between Influenza and low Vitamin D - March 2020 12 May, 2021
Flu 26 Apr, 2021
Influenza Vaccination not benefited by lowish levels of vitamin D – meta-analysis March 2018 25 Mar, 2021
Half the risk of Influenza -A in infants taking 1200 IU of vitamin D for 4 months – RCT Jan 2018 19 Mar, 2021
COVID-19 precautions made 2020 the year without the flu - what about 2021 17 Mar, 2021
7X less risk of influenza if Vitamin D levels higher than 30 ng – Oct 2017 17 Feb, 2021
Influenza prevented by 40 ng levels or treated with vitamin D hammer (50,000 IU) – June 2015 26 Dec, 2020
Why Vitamin D is better than the Flu Vaccine – Nov 2018 18 Dec, 2020
Protect your immune system from COVID-19, flu, colds, etc with 10,000 IU of vitamin D etc. - Nov 2020 05 Dec, 2020
COVID-19, flu, virus, Selenium, Vitamin D, Glutathione - Interview Sept 2020 29 Sep, 2020
Low vitamin D increases the risk of hepatitis, influenza, Covid-19, AIDS and other viral diseases – Sept 2020 21 Sep, 2020
Perhaps the influenza vaccine will increase the risk of COVID-19 (it did by 2X in 2009 Coronavirus pandemic) 08 Sep, 2020
Swine flu not prevented by 2,000 IU of vitamin D daily (the upper limit at the time) – RCT 2014 30 Aug, 2020
Vitamin D Supplements Could Reduce Risk of Influenza and COVID-19 Infection and Death - April 9, 2020 07 Apr, 2020
Vitamin D supplementation could prevent and treat influenza, CORONAVIRUS, and pneumonia infections - March 2020 30 Mar, 2020
Influenza Virus aerosols killed by 10 minutes of sunlight (far faster if use UV-C) – Nov 2019 16 Feb, 2020
Colds and flu prevented and treated by Vitamin D - many studies 27 Jan, 2020
Flu vaccinations during pregnancy should NOT be the standard of care until tests show it is OK – Nov 2019 16 Nov, 2019
Pigs use to get the flu only in the winter (got Vitamin D in the summer) - Nov 2018 11 Nov, 2019
Virus (adeno-36) increases Obesity which then increases risk of another virus (Influenza) - Oct 2013 07 Nov, 2019
2017 Flu in Australia was bad and 79,000 died in US, 2019 Flu in Australia was worse (get flu shot AND Vitamin D) 04 Oct, 2019
How Vitamin D helps fight the cold, flu and other viruses - June 2019 04 Jun, 2019
Vitamin D 10 x better than Flu Vaccine if you have very low vitamin D – Feb 2017 04 Feb, 2019
Ultraviolet light kills cold and flu viruses, and generates Vitamin D in the skin 06 Jan, 2019
Flu vaccine effectiveness and side effects 30 Sep, 2018
Influenza virus might be prevented and treated by Vitamin D, if no vaccination – Aug 2018 16 Aug, 2018
Overview Influenza and vitamin D 14 Jul, 2018
Vitamin D Effective in Preventing Flu if not vaccinated - June 2018 04 Jul, 2018
2017 Vaccine may prevent only 10 percent of influenza, Vitamin D prevents 70 percent 16 Feb, 2018
Elderly Influenza deaths do not increase in winter in countries with high vitamin D levels 09 Feb, 2018
Influenza risk reduced 2X by 2,000 IU of Vitamin D (vs 400), RTI reduced 3X by 400 or more IU – July 2017 23 Jan, 2018
Influenza reduced by 1.7 with 1200 IU D3, also reduced related asthma by 6X – RCT May 2010 10 Jan, 2018
Take Vitamin D with flu shot: 5X more likely to avoid flu and 10X fewer side effects - Jan 2018 09 Jan, 2018
Prisoners have very low vitamin D and get TB, influenza, and depression 21 Dec, 2017
Child is 2 X more likely to get influenza if have older sibling (perhaps closely-spaced birth) – Sept 2017 28 Sep, 2017
Off topic – Researchers find a hint of a link between flu vaccine and miscarriage (actually it was a 7 X increase) – Sept 2017 15 Sep, 2017
10X reactions to flu vaccine when vitamin D deficient 09 May, 2017
Influenza virus vaccine for pregnant woman does not protect a fetus for very long – July 2016 01 Aug, 2016
Influenza virus vaccine for pregnant woman does not protect an infant for very long – July 2016 01 Aug, 2016
Reduce probability of getting the Flu 02 Sep, 2015
CDC: Influenza vaccinations not expected to work well this year (but vitamin D should) – Dec 2014 24 Mar, 2015
Major interactions between Vitamin D, Vitamin A, and Influenza – Sept 2013 05 Dec, 2014
Influenzas – both seasonal and pandemic – increase in the winter (low vitamin D) – Dec 2010 07 Nov, 2014
Influenza, solar radiation and vitamin D - 2009 07 Nov, 2014
Influenza vaccine meta-analysis found moderate protection – Lancet Oct 2011 16 Oct, 2014
Ebola - tents probably faster and better than buildings - like in Spanish Flu 11 Oct, 2014
On the epidemiology of influenza – 2008 09 Oct, 2014
Epidemic influenza and vitamin D – 2007 09 Oct, 2014
Influenza A: 5X reduction in first month (only) with 2,000 IU of vitamin D– RCT July 2014 14 Jul, 2014
Influenza, seniors and vitamin D – Jan 2012 27 Apr, 2014
Reduction in Cold and Flu with Vitamin D 07 Dec, 2013
Influenza Mortality not well modeled by vitamin D – Oct 2011 02 Sep, 2013
Influenza in Norway not reduced by vitamin D – Oct 2011 03 Sep, 2012
Flu Hits 14 year low, perhaps Vitamin D 02 Apr, 2012
Should seniors get a vitamin D booster shot for Influenza – Jan 2012 19 Dec, 2011
Can Vitamin D Replace Flu Shots – WSJ Dec 2010 17 Jul, 2011
Elderly taking extra vitamin D should expect fewer falls AND less flu – June 2011 07 Jun, 2011
Pregnant women at increased influenza risk – letter to editor Aug 2010 21 Aug, 2010
Influenza not reduced by 2000 IU of vitamin D in health adults – Aug 2010 17 Aug, 2010
Flu incidence based on prescriptions – US updated map – Late 2019 No value for &#039;modification_date_major&#039;

Created by admin. Last Modification: Friday October 22, 2021 16:49:43 GMT-0000 by admin. (Version 11)

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16470 IMV low D Influenza.jpg admin 22 Oct, 2021 16:12 38.24 Kb 39
16469 IMV low D.jpg admin 22 Oct, 2021 16:11 41.16 Kb 44
16468 Vit D COVID Influenza.pdf PDF 2021 admin 22 Oct, 2021 16:03 760.46 Kb 8
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