Table of contents
- Global research on vitamin D and coronavirus disease 2019- A bibliometric and visualized study
- VitaminDWiki – COVID-19 treated by Vitamin D - studies, reports, videos
- Mortality and Virus
- Vitamin D meta-analyses of Virus
Muhammad Waseem Shah, BSc (Hons), MSc (Hons)a, Tauseef Ahmad, MPhil, PhDb, Muhammad Khan, MSc, PhDc, Shafi Muhammad, bS (Hons), MPhild, Guiju Sun, MD, PhDa*
Background and aim: Vitamin D play a substantial role in immune function, but little is known about its prevention in coronavirus disease 2019 (COVID-19). A detail bibliometric analysis of the published scientific literature indexed in Web of Science on vitamin D as a therapeutic option for the COVID-19 patients' treatment is lacking. Thus, the current study was conducted to determine the key bibliometric indices and plot the global research on vitamin D and COVID-19.
Methods: The Web of Science Core Collection database was utilized to retrieve publications on vitamin D and COVID-19. A Boolean search strategy was applied and the obtained data were exported to Microsoft Excel to generate relevant graphs. Furthermore, VOSviewer software version 1.6.17 for Windows was used to generate co-authorship countries, bibliographic coupling sources and co-occurrence keyword network visualization mapping. In addition, RStudio and Bibliometric online tool were used to generate WordCloud and thematic map, and intercountries relation map, respectively.
Results: A total of 818 publications on vitamin D and COVID-19 were included in the final analysis. These publications were cited 10,713 times, with an H-index of 50. The number of publications and citations score from 2020 to November 2021 increased from 317 (2423 citations) to 501 (8290 citations). Delanghe JR and Speeckaert MM were the most prolific authors with 13 publications each. The most productive journal was Nutrients (n = 63). The most studied research area is nutrition dietetics. The most widely used author keywords were COVID-19 (n = 444), Vitamin D (n = 312), and SARS-CoV-2 (n = 190). The National Institute of Health and US Department of Health and Human Services were the leading funding agencies. Harvard University was the most active institution with 25 publications. The United States of America was the highly contributing and influential country in terms of publications (n = 203) and total link strength (n = 185).
Conclusion: It was concluded that an increasing trend in the number of publications on vitamin D and COVID-19 has been observed. Significantly, the majority of the research has been conducted in developed countries. Most importantly, over the time, the direction of research has been changed and the recent trend topics are vitamin D deficiency, risk and infection, and vitamin D supplementation based on KeyWords Plus. The use of vitamin D supplement is one of the promising therapeutic options for COVID-19 treatment. Therefore, the current study not only highlight the global research trends but also provide standard bibliographic information for future studies.
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-  Tan W, Zhao X, Ma X, et al. A novel coronavirus genome identified in a cluster of pneumonia cases—Wuhan, China 2019-2020. China CDC Wkly. 2020;2:61-2.
-  Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382:727-33.
-  Ciotti M, Angeletti S, Minieri M, et al. COVID-19 outbreak: an overview. Chemotherapy. 2019;64:215-23.
-  Potere N, Valeriani E, Candeloro M, et al. Acute complications and mortality in hospitalized patients with coronavirus disease 2019: a systematic review and meta-analysis. Crit Care. 2020;24:389. doi:10.1186/ s13054-020-03022-1.
-  Huang D, Lian X, Song F, et al. Clinical features of severe patients infected with 2019 novel coronavirus: a systematic review and meta-analysis. Ann Transl Med 2020;8:576.
-  Kozlov IA, Tyurin IN. Cardiovascular complications of COVID-19. Messenger Anesthesiol Resusc. 2020;17:14-22. doi:10.21292/2078-5658-2020-17-4-14-22
-  Terpos E, Ntanasis-Stathopoulos I, Elalamy I, et al. Hematological findings and complications of COVID-19. Am J Hematol. 2020;95:834-47.
-  Katz JM, Libman RB, Wang JJ, et al. Cerebrovascular complications of COVID-19. Stroke. 2020;51:e227-31.
-  Bridwell R, Long B, Gottlieb M. Neurologic complications of COVID-19. Am J Emerg Med. 2020;38:1549.e3-7.
-  Zacharias H, Dubey S, Koduri G, et al. Rheumatological complications of COVID 19. Autoimmun Rev. 2021;20:102883.
-  Kunutsor SK, Laukkanen JA. Renal complications in COVID-19: a systematic review and meta-analysis. Ann Med. 2020;52:345-53.
-  Sahu KK, Kumar R. Preventive and treatment strategies of COVID-19: from community to clinical trials. J Family Med Prim Care. 2020;9:2149-2157. doi:10.4103/jfmpc.jfmpc_728_20.
-  Gavriatopoulou M, Korompoki E, Fotiou D, et al. Organ-specific manifestations of COVID-19 infection. Clin Exp Med. 2020;20:493-506.
-  Shen C, Wang Z, Zhao F, et al. Treatment of 5 critically ill patients with COVID-19 with convalescent plasma. JAMA. 2020;323:1582-9.
-  Joshi S, Parkar J, Ansari A, et al. Role of favipiravir in the treatment of COVID-19. Int J Infect Dis. 2021;102:501-8.
-  Zhang R, Wang X, Ni L, et al. COVID-19: melatonin as a potential adjuvant treatment. Life Sci. 2020;250:117583.
-  Ren JL, Zhang AH, Wang XJ. Traditional Chinese medicine for COVID-19 treatment [published correction appears in Pharmacol Res. 2020 Mar 25;:104768]. Pharmacol Res. 2020;155:104743.
-  Fidan C, Aydogdu A. As a potential treatment of COVID-19: montelu-kast. Med Hypotheses. 2020;142:109828.
-  Trasino SE. A role for retinoids in the treatment of COVID-19? Clin Exp Pharmacol Physiol. 2020;47:1765-7.
-  Zhou Q, Chen V, Shannon CP, et al. Interferon-a2b treatment for COVID-19 [published correction appears in Front Immunol. 2020 Oct 27;11:615275]. Front Immunol. 2020;11:1061. doi:10.3389/ fimmu.2020.01061.
-  Mitchell F. Vitamin-D and COVID-19: do deficient risk a poorer outcome? Lancet Diabetes Endocrinol. 2020;8:570.
-  Meltzer DO, Best TJ, Zhang H, et al. Association of vitamin D status and other clinical characteristics with COVID-19 test results. JAMA Netw Open. 2020;3:e2019722. doi:10.1001/jamanetworkopen.2020.19722.
-  RANK1 Grant WB, Lahore H, McDonnell SL, et al. Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths. Nutrients. 2020;12:988. doi:10.3390/nu12040988.
-  Annweiler C, Hanotte B, Grandin de l’Eprevier C, et al. Vitamin D and survival in COVID-19 patients: a quasi-experimental study. J Steroid Biochem Mol Biol. 2020;204:105771.
-  Meltzer DO, Best TJ, Zhang H, et al. Association of vitamin D deficiency and treatment with COVID-19 incidence. medRxiv. Preprint posted online May 13, 2020;2020.05.08.20095893. doi:10.1101/2020.05.08.20095893
-  Munshi R, Hussein MH, Toraih EA, et al. Vitamin D insufficiency as a potential culprit in critical COVID-19 patients. J Med Virol. 2021;93:733-40.
-  Ghasemian R, Shamshirian A, Heydari K, et al. The role of vitamin D in the age of COVID-19: a systematic review and meta-analysis. Int J Clin Pract. 2021;75:e14675.
-  Gutiérrez-Salcedo M, Martinez MA, Moral-Munoz JA, et al. Some bib-liometric procedures for analyzing and evaluating research fields. Appl Intell. 2018;48:1275-87.
-  Durieux V, Gevenois PA. bibliometric indicators: quality measurements of scientific publication. Radiology. 2010;255:342-51.
-  Cecez-Kecmanovic D, Kennan MA. Chapter 5. Research methods: information, systems, and contexts. Williamson K, Johanson G. (eds.). Prahran, Victoria: Tilde Publishing, 2013; pp. 113-138.
-  Ellegaard O, Wallin JA. The bibliometric analysis of scholarly production: How great is the impact? Scientometrics. 2015;105:1809-31.
-  Birkle C, Pendlebury DA, Schnell J, et al. Web of Science as a data source for research on scientific and scholarly activity. Quant Sci Stud. 2020;1:363-76.
-  Ahmad T, Murad MA, Nasir S, et al. Trends in hepatitis A research indexed in the web of science: a bibliometric analysis over the period from 1985 to 2019. Hum Vaccin Immunother. 2021;17:3221-9.
-  Ahmad T, Haroon, Khan M, et al. Research trends in rabies vaccine in the last three decades: a bibliometric analysis of global perspective. Hum Vaccin Immunother. 2021;17:3169-77.
-  Ahmad T, Hua L, Khan M, et al. Global research trends in pediatric trauma from 1968 to 2021: a bibliometric analysis. Front Pediatr. 2021;9:762531. doi:10.3389/fped.2021.762531
-  van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics. 2010;84:523-38.
-  Cobo MJ, Lopez-Herrera AG, Herrera-Viedma E, et al. Science mapping software tools: review, analysis, and cooperative study among tools. J Am Soc Inf Sci Technol. 2011;62:1382-402.
- [ 38] Ross AC, Taylor CL, Yaktine AL, et al; Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium. editors. Dietary Reference Intakes for Calcium and Vitamin D. Washington (DC): National Academies Press (US); 2011. doi: 10.17226/13050
-  Science M, Maguire JL, Russell ML, et al. Low serum 25-hydroxyvita-min D level and risk of upper respiratory tract infection in children and adolescents. Clin Infect Dis. 2013;57:392-7.
-  Greiller CL, Martineau AR. Modulation of the immune response to respiratory viruses by vitamin D. Nutrients. 2015;7:4240-70.
-  Gombart AF, Borregaard N, Koeffler HP. Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. FASEB J. 2005;19:1067-77.
-  Wang TT, Dabbas B, Laperriere D, et al. Direct and indirect induction by 1,25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin beta2 innate immune pathway defective in Crohn disease. J Biol Chem. 2010;285:2227-31.
-  Watkins J. Preventing a COVID-19 Pandemic. British Medical Journal Publishing Group; 2020.
-  Daneshkhah A, Agrawal V, Eshein A, et al. Evidence for possible association of vitamin D status with cytokine storm and unregulated inflammation in COVID-19 patients. Aging Clin Exp Res. 2020;32:2141-58.
-  De Smet D, De Smet K, Herroelen P, et al. Vitamin D deficiency as risk factor for severe COVID-19: a convergence of two pandemics [preprint]. Infect Dis (except HIV/AIDS). 2020. doi:10.1101/2020.05.01.20079376
-  Benskin LL. A basic review of the preliminary evidence that COVID-19 risk and severity is increased in vitamin D deficiency. Front Public Health. 2020;8:513. doi:10.3389/fpubh.2020.00513
- [ 47] Hastie CE, Mackay DF, Ho F, et al. Vitamin D concentrations and COVID-19 infection in UK Biobank [published correction appears in Diabetes Metab Syndr. 2020 Sep - Oct;14(5):1315-1316]. Diabetes Metab Syndr. 2020;14:561-5.
- RANK2Ilie PC, Stefanescu S, Smith L. The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality. Aging Clin Exp Res. 2020;32:1195-8.
-  Lau FH, Majumder R, Torabi R, et al. Vitamin D insufficiency is prevalent in severe COVID-19 [preprint]. Infect Dis (except HIV/AIDS). 2020. doi:10.1101/2020.04.24.20075838
-  Bergman P, Norlin AC, Hansen S, et al. Vitamin D3 supplementation in patients with frequent respiratory tract infections: a randomized and double-blind intervention study. BMJ Open. 2012;2:e001663. doi:10.1136/bmjopen-2012-001663
-  Hicks D, Melkers J. bibliometrics as a tool for research evaluation. In: Link AN, Vonortas NS, (eds.). Handbook on the Theory and Practice of Program Evaluation, chapter 11. pp. 323-349. Edward Elgar Publishing. 2013.
-  Ahmad T, Murad MA, Baig M, et al. Research trends in COVID-19 vaccine: a bibliometric analysis. Hum Vaccin Immunother. 2021;17:2367-72.
-  Shi J, Gao Y, Ming L, et al. A bibliometric analysis of global research output on network meta-analysis. BMC Med Inform Decis Mak. 2021;21:144.
- [ 54] Zhang W, Tang N, Li X, et al. The top 100 most cited articles on total hip arthroplasty: a bibliometric analysis. J Orthop Surg Res. 2019;14:412. doi:10.1186/s13018-019-1476-3.
-  Nasir S, Ahmed J, Asrar M, et al. A bibliometric analysis of pharmacy/ pharmacology research in Pakistan. Int J Pharmacol. 2015;11:766-72. doi:10.3923/IJP.2015.766.772
-  Maeda K, Rahman M, Fukui T. Japan’s contribution to clinical research in gastroenterology and hepatology. J Gastroenterol. 2003;38:816-9.
-  Glaser J, Velarde KS. Changing funding arrangements and the production of scientific knowledge: introduction to the special issue. Minerva. 2018;56:1-10. doi:10.1007/s11024-018-9344-6.
-  Nafade V, Nash M, Huddart S, et al. A bibliometric analysis of tuberculosis research, 2007-2016. PLoS One. 2018;13:e0199706. doi:10.1371/ journal.pone.0199706.
-  Shah SM, Ahmad T, Chen S, et al. A bibliometric analysis of the one hundred most cited studies in psychosomatic research. Psychother Psychosom. 2021;90:425-30.
-  Moed HF. New developments in the use of citation analysis in research evaluation. Arch Immunol Ther Exp (Warsz). 2009;57:13-8.
VitaminDWiki – COVID-19 treated by Vitamin D - studies, reports, videos
As of Nov 25, 2022, the VitaminDWiki COVID page had: 19 trial results, 37 meta-analyses and reviews, Mortality studies see related: Governments, HealthProblems, Hospitals, Dark Skins, 26 risk factors are ALL associated with low Vit D, Recent Virus pages Fight COVID-19 with 50K Vit D weekly Vaccines Take lots of Vitamin D at first signs of COVID 116 COVID Clinical Trials using Vitamin D (08/2022)
5 most-recently changed Virus entries
Mortality and Virus
This list is automatically updated
- Cost to prevent a COVID death: 11 dollars of Vitamin D - Nov 2022
- Number needed to vaccinate to prevent 1 Omicron death: 30,000 for age 60-70 - Sept 2022
- COVID survival in Europe in 2020 best predicted by population-level Vitamin D (of 13 variables) – July 2022
- Elderly who had been in COVID ICU were 4X more likely to die if low vitamin D – Nov 2022
- More COVID mortality if less than 20 ng of Vitamin D (Mexico) – May 2022
- 15,000,000 excess deaths in 2 years - May 2022
- COVID death 5.2X more likely if Vitamin D deficient – May 2022
- 29 X more likely to die of COVID if less than 20 ng of Vitamin D - March 2022
- Giving Vitamin D reduced COVID Mortality– Review of 11 studies – March 2022
- 18 million excess global deaths in past 2 years: COVID plus collateral damage - Lancet March 2022
- COVID severity and death more likely if low vitamin D (Egypt this time) - March 2022
- US nursing homes are epicenters for COVID deaths (200,000) - Feb 2022
- Ivermectin taken before COVID decreased death rate by 68 percent (3,000 with Ivermectin vs 3,000 without) - Dec 24, 2021
- Increase in non-COVID deaths (ages 18-64) in Indiana, India, etc. - Jan 5, 2022
- Only 35,000 died in US of COVID who previously had been healthy
- COVID-19 mortality extrapolates to zero at 50 ng of vitamin D – 18th Meta-analysis Sept 2021
- COVID-19 patients getting 300,000 IU of Vitamin D were 5X less likely to die – Sept 2021
- Predict 2X more likely to die of COVID-19 if vitamin D Deficient (Iran 2020) – Sept 2021
- COVID-19 mortality not associated with Vitamin D (everyone had very low levels) -Sept 2021
- COVID-19 mortality for Blacks is 5X that for whites in 2 LA Hospitals - July 2021
- COVID-19 mortality was associated with vitamin D deficiency of 47 countries – July 2021
- Similar death rate for Vaccination and COVID-19 study and video – June 24, 2021
- COVID-19 death in hospital 5X more likely if low vs high vitamin D – preprint June 2021
- COVID-19 deaths 1.7X more likely if low vitamin D (even after “adjusting” for low D health problems) – May 2021
- COVID-19 deaths 1.5X less likely if more than 40 ng of vitamin D – US VA – April 2021
- Vitamin D supplementation and high levels reduce COVID-19 deaths in elderly – Review April 17, 2021
- Less COVID-19 infection, mortality in countries with higher Vitamin D (Asia in this case) – May 2021
- COVID-19 was the third-leading cause of death in the US, especially in those with dark skins - April 1, 2021
- Risk of COVID-19 death was 4.9 X higher if very low vitamin D – March 31, 2021
- COVID-19 mortality 2X higher if low Vitamin D (Mexican hospital, preprint) - March 2021
- All COVID-19 patients had low vitamin D, the lowest were more likely to die – Feb 18, 2021
- 2.7 fewer COVID-19 hospital deaths in those having more than 30 ng of vitamin D – Mayo Jan 9, 2021
- Worse COVID-19 patients got 400,000 IU of vitamin D, deaths cut in half – Jan 14, 2021
- Iranians with COVID-19 were 2.3 X more likely to die if low vitamin D – Jan 2021
- Poor COVID-19 prognosis was 6 X more likely if low vitamin D – Jan 21, 2021
- Less than 10 dollars of Vitamin D per COVID-19 life saved in Myanmar - Jan 2021
- 2.8 X fewer COVID-19 nursing home deaths if add 10,000 IU Vitamin D daily for a week (small observation)- Jan 2021
- Italian nursing home COVID-19 – 4X less likely to die if taking Vitamin D– Dec 22, 2020
- Shift workers 2X more likely to get COVID-19 (low Vitamin D) - Dec 2020
- Those getting high dose vitamin D were 7 X less likely to die of COVID-19 - Dec 11, 2020
- COVID-19 male mortality increased 3.9 X if low vitamin D – observation Nov 25, 2020
- Hospital COVID-19 observation: 7X more likely to live if more than 20 ng of vitamin D– Nov 19, 2020
- COVID-19 lung death 4X more likely in Iran if less than 25 ng of vitamin D – Oct 30, 2020
- COVID-19 was killing dark-skinned doctors, then they got a Vitamin D recommendation
- 9X COVID-19 survival in nursing home if had 80,000 IU dose of vitamin D in previous month – Oct 2020
- 14.7 X more likely to die of COVID-19 if less than 12 ng of Vitamin D (185 Germans) – Sept 10, 2020
- COVID ARDS deaths 2X more likely if less than 10 ng of Vitamin D – Aug 8, 2020
- COVID-19 mortality rate highest North of 35 degrees latitude (Vitamin D) – April 20, 2020
- COVID-19 more frequent and deadly for those with dark skins (high risk of low vitamin D)
Vitamin D meta-analyses of Virus
This list is automatically updated
COVID vitamin D publications - bibliometric analysis - July 2022
- Severe COVID 2.6 X less likely if supplement with Vitamin D – 26th meta-analysis - July 2022
- COVID test positive is about half as likely if have Vitamin D – 24th meta-analysis - Jan 2022
- Small amounts of Vitamin D reduce Influenza risk by 22 percent (loading dose is far better) – meta-analysis Jan 2022
- Vitamin D fights COVID (54 studies of 1,400,000 people) – 23rd meta-analysis - Dec 2021
- COVID-19 treated by Vitamin D (reduce ICU by 3X) - 22nd meta-analysis - Dec 29, 2021
- COVID-19 death increased 2X if low Vitamin D (less than 10 to less than 30 ng) – 21st meta-analysis Dec 2021
- COVID-19 risk reduced by vitamin D supplementation – umbrella review of 7 meta-analysis – Oct 2021
- COVID-19 treated by Vitamin D (example: ICU reduced by 5X) – 20th meta-analysis Oct 13, 2021
- Severe COVID-19 2.5 X more likely if low vitamin D (23 studies) – 19th meta-analysis Oct 2021
- COVID-19 mortality extrapolates to zero at 50 ng of vitamin D – 18th Meta-analysis Sept 2021
- COVID-19 death 1.6 X more likely if low vitamin D (24 studies) – 17th meta-analysis Aug 2021
- Severe COVID-19 5X more likely if low vitamin D (23 studies) – 16th meta-analysis July 2021
- Severe COVID-19 3.5 more likely if low vitamin D (30 studies) – meta-analysis July 2021
- COVID-19 patients who had supplemented with Vitamin D were 3X less likely to enter ICU – June 2021
- Low Calcium associated with severe COVID-19 – several studies
- COVID-19 mortality 3X more likely if low vitamin D (999,179 people) – meta-analysis March 29, 2021
- COVID-19 was 2.6X more severe if very low Vitamin D (43 studies) – meta-analysis March 26, 2021
- Low Vitamin D associated with 2.7X more severe COVID-19 – 12th MA March 5, 2021
- Vitamin D supplementation fights COVID-19 – 11th meta-analysis Jan 24, 2021
- 3.7 X less likely to die of COVID-19 if supplemented with Vitamin D - meta-analysis Jan 5, 2021
- Less likely to test positive for COVID-19 if higher Vitamin D – meta-analysis Jan 6, 2021
- Vitamin D reduces COVID-19 by 80 percent - anonymous meta-analysis - Jan 5, 2021
- COVID-19 1.7X more likely to be severe if low Vitamin D - meta-analysis Oct 2020
- Low Vitamin D associated 1.8X increased risk of COVID-19 death in hospital – meta-analysis Nov 4, 2020
- Acute viral respiratory infections (RTI) reduced by Vitamin D - 20 reviews - Aug 2020
- Prudent to consider that Vitamin D has a role in COVID-19 – meta-analysis – Aug 7, 2020
- Risk of enveloped virus infection is increased 50 percent if poor Vitamin D Receptor - meta-analysis Dec 2018
- Hepatitis B patients have 2 ng lower level of Vitamin D – meta-analysis June 2019
- Influenza Vaccination not benefited by lowish levels of vitamin D – meta-analysis March 2018
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- Vitamin D meta-analyses of Virus