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COVID in hospital fought by Vitamin D (25,000 IU daily for 4 days, then 25K weekly) - RCT – July 2022

Positive Effects of Vitamin D Supplementation in Patients Hospitalized for COVID-19: A Randomized, Double-Blind, Placebo-Controlled Trial

Nutrients 2022, 14(15), 3048; https://doi.org/10.3390/nu14153048
Sophie De Niet et.all


Retrospective studies showed a relationship between vitamin D status and COVID-19 severity and mortality, with an inverse relation between SARS-CoV-2 positivity and circulating calcifediol levels. The objective of this pilot study was to investigate the effect of vitamin D supplementation on the length of hospital stay and clinical improvement in patients with vitamin D deficiency hospitalized with COVID-19. The study was randomized, double blind and placebo controlled. A total of 50 subjects were enrolled and received, in addition to the best available COVID therapy, either vitamin D (25,000 IU per day over 4 consecutive days, followed by 25,000 IU per week up to 6 weeks) or placebo.
The length of hospital stay decreased significantly in the vitamin D group compared to the placebo group (

  • 4 days vs. 8 days; p = 0.003).

At Day 7, a significantly lower percentage of patients were

  • still hospitalized in the vitamin D group compared to the placebo group (19% vs. 54%; p = 0.0161),

and none of the patients treated with vitamin D were hospitalized after 21 days compared to 14% of the patients treated with placebo.
Vitamin D significantly reduced the duration of supplemental oxygen among the patients who needed it (4 days vs. 7 days in the placebo group; p = 0.012) and significantly improved the clinical recovery of the patients, as assessed by the WHO scale (p = 0.0048). In conclusion, this study demonstrated that the clinical outcome of COVID-19 patients requiring hospitalization was improved by administration of vitamin D.
 Download the PDF from VitaminDWiki

Note: All participants initially had <20 ng of vitamin D

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VitaminDWiki – COVID-19 treated by Vitamin D - studies, reports, videos

As of Oct 4, 2023, the VitaminDWiki COVID page had:  19 trial results,   37 meta-analyses and reviews,   Mortality studies   see related:   Governments,   HealthProblems,   Hospitals,  Dark Skins,   All 26 COVID risk factors are associated with low Vit D,   Fight COVID-19 with 50K Vit D weekly   Vaccines   Take lots of Vitamin D at first signs of COVID   166 COVID Clinical Trials using Vitamin D (Aug 2023)   Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
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Created by admin. Last Modification: Sunday October 2, 2022 01:07:28 GMT-0000 by admin. (Version 4)

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18533 COVID 25K table.jpg admin 02 Oct, 2022 00:52 146.61 Kb 179
18532 COVID 25,000.jpg admin 02 Oct, 2022 00:52 38.41 Kb 230
18531 COVID 25K_CompressPdf.pdf PDF 2022 admin 02 Oct, 2022 00:52 217.33 Kb 137