Toggle Health Problems and D

COVID children with multisystem inflammatory syndrome have less than 10 ng of vitamin D – March 2022

Progress in Pediatric Cardiology. 1 March 2022, https://doi.org/10.1016/j.ppedcard.2022.101507
DianaTorpoco-RiveraaAmritMisraaYamunaSanilaNatalieSabzghabaeibRayaSafaacRichard U.Garciaac




Multisystem inflammatory syndrome (MIS-C) is a clinical presentation reported in children related to Coronavirus-19 infection who present with a toxic shock like syndrome. Vitamin D deficiency has been postulated to play a role with severity of coronavirus infection in adult patients and other viral respiratory infections.

This study aims to investigate if severe vitamin D deficiency was associated with increased disease severity and cardiac involvement in MIS-C.

This is a retrospective and single center study. We included hospitalized patients less than 18 years of age with diagnosis of MIS-C between March and July 2020. Severe vitamin D deficiency was defined as 25-OH vitamin D level < 10 ng/ml within 48 h of admission. The composite outcome severe disease included patients requiring inotropes, mechanical ventilation, and extracorporeal membrane oxygenation.

Of the 31 patients with MIS-C, 45% were male and 58% were African American. The median age was 8 (1–13) years. Ten patients had severe vitamin D deficiency with a mean level of 7.2 ng/ml. Ninety percent of patients with severe vitamin D deficiency had severe disease (P < 0.001). Patients with severe vitamin D deficiency had an increased risk of cardiac involvement (P < 0.001).

We describe a potential association between severe vitamin D deficiency and severe disease in children presenting with MIS-C. Severe vitamin D deficiency predisposes patients for cardiovascular involvement and, may play a critical role in the host immune response to COVID-19 infection. Future prospective studies at the basic science and clinical level should be pursued to better delineate this association.
 Download the PDF from VitaminDWiki

 Download the PDF from VitaminDWiki


VitaminDWiki studies in Children + Inflammation + Virus

This list is automatically updated

Created by admin. Last Modification: Friday March 4, 2022 19:10:00 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
17155 MIS-C Jan 2022.pdf PDF 2022 admin 04 Mar, 2022 19:09 125.96 Kb 175
17144 Table 3b.jpg admin 01 Mar, 2022 16:29 83.11 Kb 211
17143 Table 3a.jpg admin 01 Mar, 2022 16:28 14.79 Kb 191
17142 MIS-C table.jpg admin 01 Mar, 2022 16:28 92.43 Kb 199
17141 Days in ICU.jpg admin 01 Mar, 2022 16:27 33.68 Kb 189
17140 Vitamin D and morbidity in children with multisystem inflammatory syndrome.pdf PDF 2022 admin 01 Mar, 2022 16:21 755.13 Kb 206