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COVID 3X less likely if Xyilotol nasal spray 3X per day – RCT Dec 2022

Evaluating the efficacy and safety of a novel prophylactic nasal spray in the prevention of SARS-CoV-2 infection: A multi-centre, double blind, placebo-controlled, randomised trial.

Journal of Clinical Virology Volume 155, October 2022, 105248 https://doi.org/10.1016/j.jcv.2022.105248
Damian Balmforth a, James A Swales b, Laurence Silpa b c, Alan Dunton d, Kay E. Davies e, Stephen G. Davies f, Archana Kamath g, Jayanti Gupta h, Sandeep Gupta i, M.Abid Masood b, Áine McKnight j, Doug Rees b, Angela J. Russell c f, Manu Jaggi k, Rakesh Uppal a l

Background The COVID-19 pandemic continues to devastate communities all over the world. The aim of this study was to evaluate the efficacy and safety of the test agent as a prophylaxis against SARS-CoV-2 infection in a population of high-risk healthcare workers.

Methods The study was a multi-centre, prospective, double blind, randomized, placebo-controlled trial. Key eligibility criteria included absence of significant co-morbidity and no previous SARS-CoV-2 infection or vaccination. Participants were randomised to either the active agent nasal spray or placebo using computer generated random number tables. The nasal spray was administered 3 times daily over a 45 day course. The primary end point was the percentage of subjects who tested positive for IgGS (anti-spike, immunoglobulin G specific to the spike protein of SARS-CoV-2) at day 45.

Results Between 16th April 2021 and 26th July 2021, 556 participants were analysed for the primary endpoint (275 Test; 281 Placebo). The test agent significantly reduced SARS-CoV-2 infection compared to placebo [36 cases (13.1%) Vs 97 cases (34.5%); OR 0.29 (95% CI; 0.18–0.45), p < 0.0001]. Fewer clinical symptoms were also seen in the test group [57 cases (17.6%) vs 112 cases (34.6%); OR 0.40, (95% CI; 0.27–0.59), p < 0.0001]. No harmful effects were associated with taking the test agent.

Conclusion The test agent significantly reduced SARS-CoV-2 infection in healthcare workers, with 62% fewer infections when compared to placebo. It was found to be safe and well tolerated and offers a novel treatment option for prophylaxis against SARS-CoV-2 infection.
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19284 Inhaled Xyilotol RCT.pdf PDF 2022 admin 24 Feb, 2023 23:37 448.03 Kb 29