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COPD severity is associated with Vitamin D deficiency – meta-analysis Sept 2015

Vitamin D deficiency is associated with the severity of COPD: a systematic review and meta-analysis

International Journal of Chronic Obstructive Pulmonary Disease » Volume 10 » Issue 1 pg 1907—1916, DOI http://dx.doi.org/10.2147/COPD.S89763



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Biyuan Zhu,1,* Biqing Zhu,2,* Chaolie Xiao,3 Zhiwen Zheng1
1The Fifth Internal Medicine Department, 2 Department of Laboratory Medicine, 3Department of Intensive Care Unit, Dongguan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Dongguan City, People’s Republic of China
*These authors contributed equally to this work

Purpose: To explore the association between host serum 25-hydroxyvitamin D (25(OH)D) and the susceptibility and severity of COPD.

Methods: Previous studies on the association between host 25(OH)D and the susceptibility and severity of COPD were collected on the basis of a systematic literature search of PubMed and Web of Science up to June 2015. Continuous variable data were presented as standard mean difference (SMD) or weighted mean difference with 95% confidence interval (CI). The dichotomous variable data were analyzed as relative ratio (RR) or odds ratio with 95% CI for cohort and case-control studies. A systematic review was conducted to understand the curative and side effects of vitamin D intake.

Results: A total of 18 studies including eight cohort, five case-control, and five randomized studies met the inclusion criteria. The serum level of 25(OH)D in COPD patients was comparable with controls with a pooled SMD of 0.191 (95% CI: -0.126 to 0.508, P=0.237) based on pooled analyses of cohort studies. However, the serum level of 25(OH)D in COPD patients was lower with a pooled SMD of 0.961 (95% CI: 0.476–1.446, P<0.001) compared with controls based on pooled analyses of case-control studies. The deficiency rates of 25(OH)D were comparable between controls and COPD patients with a pooled RR of 0.955 (95% CI: 0.754–1.211, P=0.705) based on analyses of cohort studies, and the same results were observed based on pooled analyses of case-control studies. Interestingly, the deficiency rate of 25(OH)D was significantly lower in moderate or severe COPD patients with a pooled RR of 0.723 (95% CI: 0.632–0.828, P<0.001) compared with that in mild COPD patients. The same results were obtained from the pooled analysis between moderate and severe COPD patients. The four randomized studies showed that vitamin D intake provided benefit for COPD patients.

Conclusion: Low serum levels of 25(OH)D were not associated with COPD susceptibility, but the high deficiency rate of 25(OH)D was associated with COPD severity. Vitamin D supplementation may prevent COPD exacerbation.

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Attached files

ID Name Comment Uploaded Size Downloads
5920 COPD mild moderate.jpg admin 14 Sep, 2015 02:24 40.47 Kb 575
5919 COPD Forest.jpg admin 14 Sep, 2015 02:24 50.75 Kb 1149
5918 COPD severity.pdf PDF admin 14 Sep, 2015 02:23 659.12 Kb 421
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