Loading...

Toggle Health Problems and D

Breast cancer may result from poor interaction with vitamin D – Sept 2010

Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions.

BMC Cancer. 2010 Sep 11;10(1):483.
Lopes N, Sousa B, Martins D, Gomes M, Vieira D, Veronese LA, Milanezi F, Paredes J, Costa JL, Schmitt F.

BACKGROUND: Breast cancer is a heterogeneous disease associated with different patient prognosis and responses to therapy. Vitamin D has been emerging as a potential treatment for cancer, as it has been demonstrated that it modulates proliferation, apoptosis, invasion and metastasis, among others. It acts mostly through the Vitamin D receptor (VDR) and the synthesis and degradation of this hormone are regulated by the enzymes CYP27B1 and CYP24A1, respectively. We aimed to study the expression of these three proteins by immunohistochemistry in a series of breast lesions.

METHODS: We have used a cohort comprising normal breast, benign mammary lesions, ductal carcinomas in situ and invasive carcinomas and assessed the expression of the VDR, CYP27B1 and CYP24A1 by immunohistochemistry.

RESULTS: The results that we have obtained show that all proteins are expressed in the various breast tissues, although at different amounts. The VDR was frequently expressed in benign lesions (93.5%) and its levels of expression were diminished in invasive tumours (56.2%). Additionally, the VDR was strongly associated with the oestrogen receptor positivity in breast carcinomas. CYP27B1 expression is slightly lower in invasive carcinomas (44.6%) than in benign lesions (55.8%). In contrast, CYP24A1 expression was augmented in carcinomas (56.0% in in situ and 53.7% in invasive carcinomas) when compared with that in benign lesions (19.0%).

CONCLUSIONS: From this study, we conclude that there is a deregulation of the Vitamin D signalling and metabolic pathways in breast cancer, favouring tumour progression. Thus, during mammary malignant transformation, tumour cells lose their ability to synthesize the active form of Vitamin D and respond to VDR-mediated Vitamin D effects, while increasing their ability to degrade this hormone.

PMID: 20831823 – CLICK HERE to get to PDF

Breast cancer may result from poor interaction with vitamin D – Sept 2010

3915 visitors, last modified 18 Sep, 2010,

Printer Friendly Follow this page for updates

This page is in the following categories (# of items in each category)

Cancer - Breast 243

Edit

“One pill every two weeks fights diabetes, cancers, heart failure, and 21 other diseases.”

Click for details

Health Problems and D

15,500+ pages in VitaminDWiki
Topic (# in topic)

Acne (20+ studies)

Attention Deficit Hyperactivity Disorder/ADHD (49+)

Alcohol (29+)

Allergy (120+) Overview

Amyotrophic Lateral Sclerosis/ALS (30+)

Alzheimer's (81+) Overview

Ankylosing Spondylitis (20+)

Antibiotics/Probiotics (92+) Overview

Asthma (145+) Overview

Atopic Dermatitis Overview (18+)

Autism (157+) Overview

Vit. D Receptor (14+)

Transgender (19+)

Autoimmune (199+)

Systemic Sclerosis (10+)

Back Pain (43+)

Lumbar Degeneration (14+)

Bipolar Disorder (16+)

Bone - Health (311+)

BMD, Bone loss (55+)

Breathing (450+)

Hay Fever (20+)

Pneumonia (50+)

Respiratory (82+)

Burns/Wounds (30+)

Cancer (292+) Overview

After diagnosis (113+)

Bladder (28+)

Bone (8+)

Breast (256+) Overview

Child (16+)

Colon (144+) Overview

Endometrial (5+)

Gastric (9+)

Leukemia (19+)

Liver (17+)

Lung (55+) Overview

Lymphoma (26+)

Mg and Cancer (13+)

Melanoma (43+)

Multiple Myeloma (10+)

Metastatic (17+)

Other (66+)

Ovarian (26+)

Palliative Care (10+)

Pancreatic (57+)

Prostate (103+) Overview

Skin (121+) Overview

Survive (37+)

Thyroid (7+)

{DIV}

Cardiovascular (526+) Overview

Atherosclerosis (56+)

Atrial Fibrillation (20+)

Heart Failure (47+)

HRV (10+)

Omega-3 (38+)

Statins (80+)

Carpal Tunnel Syndrome (12+)

Cerebral Palsy (6+)

Cholesterol (52+) Overview

Chronic Fatigue (7) Overview

Cognitive (389+) Overview

Anesthesia ==> Cog

Brain (103+)

Delirium (9+)

Dementia (50+)

Mental Illness (300+)

Mental Stress (10+)

Colds/flu Overview

Concussions (25+)

Chronic obstructive pulmonary disease/COPD (17+)

COVID-19 (1300+)

Cystic Fibrosis (51+)

Dental (116+)

Fluoridation (16)

Depression (267+)

Anxiety ( 11+)

Omega-3 (29)

SAD (9)

Diabetes (548+) Overview

Hemodialysis (41+)

Magnesium (27+)

Meta-analyses (39+)

Metabolic Syndrome + Mg

Neuropathy (15+)

Prediabetes (30+)

Red Meat (4+)

Retinopathy (8+)

Type 1 Diabetes (46+)

Vitamin D Receptor (23+)

Zinc (5+)

Diseases general (93+)

Ear (17+)

Otitis Media (10+)

Endometriosis (8+)

Falls/Fractures (258+) Overview

Fatigue, Chronic Overview

Fertility/Sperm (141+)

Erectile Dysfunction (12+)

In Vitro Fert. (18+)

Testosterone (14+)

Fibromyalgia Overview

Fractures Overview

Ankle (16+)

Bone & Stress Fractures

Bone Mineral Density (28+)

Children (16+)

Hip Fractures (68+)

Vertigo (22+)

Genetics (343+)

CYP24A1 (31+)

CYP24R1 (25+)

CYP27B1 (62+)

Epigenetics (18+)

Telomere (12+)

Vit D Binding (177+)

Vit D Receptor (517+)

Cancer in VDR (79+)

Gestational Diabetes (34+)

Gout (13+)

Gut (206+) Overview

Bariatric (15+)

Celiac (7+)

Clostridium difficile (9+)

Crohn's (38+)

IBD (28+)

IBS (18+)

Ulcerative Colitis (12+)

Hair (20+)

Alopecia Areata (8+)

Health - general (109+)

Human Immunodeficiency Virus/HIV (45+) Overview

Hives (10+)

Hypertension (166+) Overview

Pregnancy (41+)

Hyperparathyroid Overview

Immunity (273+)

Inflammation (173+)

CRP (19+)

Infection (141+)

Influenza Overview

Kidney (228+) Overview

Chronic Kidney (63+)

Dialysis (39+)

Kidney Stones (29+) Overview

Leprosy (16+)

Liver (102+) Overview

Hepatitis-B (12+)

Hepatitis-C (13+)

NAFLD (27+)

Lyme Disease (9+)

Lupus (77+)

Mental Illness (20+)

Mental Stress (5+)

Metabolic Syndrome (105+) Overview

Mortality (296+)

Multiple Sclerosis (412+) Overview

Genetics and Receptor (32+)

Virus (16+)

Muscle (113+)

Handgrip (12+)

Sarcopenia (30+)

Muscular Dystrophy (9+)

Myopia (17+)

Obesity (441+)Overview

Child & Youth (60+)

Vitamin D Receptor (16+)

Virus and Obesity (25+)

Weight Loss (31+)

Osteoarthritis (60+) Overview

Knee (26+)

Osteoporosis (218+) Overview

BMD (26+)

Pain - chronic (165+) Overview

Magnesium (13+)

Pancreatitis (20+)

Parkinson's (117+) Overview

Pneumonia (22+)

Pollution (31+)

Pregnancy (918+) Overview

Breastfed (38+)

Caesarean (15+)

Depression (21+)

Dark Skin (30+)

Gestational Diabetes (41+)

In Vitro Fert. (18+)

Iodine (21+)

Low Birth Weight (23+)

Magnesium (30+)

Miscarriage (31+)

Multiple Sclerosis (13+)

Omega-3 before and during (49+)

PCOS (15+)

Preeclampsia (55+)

Preterm (125+)

Preterm - Omega-3 (13+)

Stillbirth (8+)

Prostate - BPH (16+)

Psoriasis (72+)

Respiratory Tract Infection/RTI (8+)

Restless Legs Syndrome (15+)

Rheumatoid Arthritis (117+) Overview

Juvenile RA (9+)

Rickets (127+) Overview

Sarcopenia (28+)

Schizophrenia Overview

Sepsis (201+)

Sickle Cell (20+) Overview

Skin (120+) Overview

Aging

Atopic Dermatitis(27+)

Hives

Vitiligo (8+)

Sleep (101+)

Sleep Apnea(12+)

Smoking (83+)

Spinal Cord (20+)

Spinal Surgery (13+)

Statins (40+)

Stroke (131+) Overview

Cognitive Impairment (15+)

Depression (9+)

Ischemic (21+)

Thyroid/Parath. (82+) Overview

PTH (34+)

Trauma/Surgery (347+)

Bariatric surgery (12+)

Bone surgery (23+)

ICU & Loading Dose (69+)

Need Vit D (69+)

Ortho. & Hip (69+)

Sepsis (41+)

Transplant (31+)

Traumatic Brain Injury (24+)

Tuberculosis (124+) Overview

Urinary Tract Infection (15+)

Virus (1391+)

All studies

Bird Flu

Cardiovascular (19+)

Cancers after VAX (17+)

Child - years after VAX (11+)

Cognitive (10+)

Dengue (27+)

Epstein-Barr Virus (20+)

Excess Deaths (23+)

Hepatitis (29+)

Herpes or Shingles (13+)

Ivermectin (35+)

Long-COVID (72+)

Magnesium (60+)

Masks (11+)

Meta-analyses (40+)

Omega-3 (14+)

Pfizer (20+)

RSV (12+)

Ultraviolet light (16+)

Vaccination (198+)

Vitamin D (650+)

Vitamin D Receptor (31+)

Vitamin K

Zinc (32+)

Vision (110+)

Cataracts (12+)

Dry Eye (15+)

Glaucoma (8+)

Macular Degeneration (14+)

Myopia (20+)

People and Low Vitamin D

Infant/Child (850+)

Allergy (36+)

Cancer (13+)

Cerebral Palsy (15+)

Down Syndrome (5+)

Fracture, low energy (10+)

Growing Pains (10+)

Pneumonia (25+)

Preemie (25+)

Puberty early if low D (9+)

Respiratory (21+)

RSV (25+)

Tonsils (9+)

Vaccination (10+)

Virus (42+)

Military (27+)

Veterans (17+)

Prisoners (14+)

Seniors (431+) Overview

Aging (38+)

Essential Tremor (4+)

Frailty (20+)

Longevity (47+)

Nursing Homes (19+)

Sarcopenia (25+)

Urinary incontinence (15+)

Vertigo (22+)

Skin - Dark (460+) Overview

Pregnancies (30+)

Sports (277+) Overview

Exercise (68+)

Muscle (138+)

Traumatic Brain Inj. (24+)

Women (196+) Overview

Endometriosis (25+)

Incontinence (16+)

Menopause (17+)

PCOS

Premenstrual Syndrome (20+)

Uterine Fibroid (13+)

Yeast Infection

Youth (173+)

Early Puberty (15+)

Locations

World (14+)

Aust NZ (68+)

Africa (28+)

Europe (233+)

India (65+)

Iceland (40+)

Middle East (152+)

Orient (76+)

Russia (12+)

Scotland (20+)

Far from Equator (124+)

Click here to search the site
A list includes 282+ pages having many studies
# of studies as of Oct 20, 2024