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Breast Cancer survival worse if low Vitamin D and poor Vitamin D receptor – April 2019

Vitamin D and Breast Cancer. Studies on Incidence and Survival

Huss, Linnea LU PHD Dissertation

VitaminDWiki

Items in both categories Breast Cancer and Vitamin D Receptor are listed here:

52 diseases were strongly associated with Vitamin D Receptor as of April 2019__
Vitamin D Receptor table shows what compensates for low VDR activation

Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus to the cells
2) MagnesiumVitamin D in the blood
 AND to the cells
3) Omega-3 Vitamin D to the cells
4) Resveratrol Vitamin D to the cells
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation.
You might feel the benefit within days of adding one or more of the above

 Download the PDF from VitaminDWiki

Breast Cancer Survival if have low levels of Vitamin D at time of diagnosis
Image
Note: Increase survival if increase Vitamin D and/or increase VDR activation

Previous research has suggested beneficial effects of vitamin D on both breast cancer risk and prognosis. The overall aim of this research project was to investigate associations between vitamin D and breast cancer. The population-based prospective cohort, the Malmö Diet and Cancer Study, recruited 17,034 women in the first half of the 1990s. Studies in in the current thesis are based on blood samples collected at baseline, analyzed for levels of vitamin D, parathyroid hormone (PTH), calcium and later also used for genetic sequencing. Breast tumors that developed in women within the cohort were included in a tissue microarray and analyzed for expression of the vitamin D receptor (VDR).
Specific aims were to investigate:

  • I. Serum levels of vitamin D, PTH and calcium in relation to breast cancer survival, i.e. mortality among women diagnosed with breast cancer.
  • II. Vitamin D-related single nucleotide polymorphisms (SNPs) and breast cancer risk.
  • III. Expression of VDR in association with breast cancer mortality.
  • IV. Levels of vitamin D in relation to expression of VDR in subsequent breast tumors.

Results and conclusions:

  • I. Compared to intermediate levels of vitamin D, low levels and high levels were associated with a poor survival, i.e. high risk of death related to breast cancer. No association was found between PTH and breast cancer mortality. Relatively high serum calcium levels were associated with relatively low breast cancer mortality.
  • II. SNPs associated with levels of vitamin D did not affect breast cancer risk. One SNP, related to the vitamin D binding protein, was associated with breast cancer risk.
  • III. VDR expression was associated with a favorable breast cancer prognosis.
  • IV. There were indications that vitamin D levels were associated with VDR expression in a subsequent breast tumor.

The association between low vitamin D levels and high breast cancer mortality may be mediated through development of a VDR-negative tumor. There was no evidence to suggest an additional beneficiary effect of vitamin D levels higher than intermediate levels.

Created by admin. Last Modification: Wednesday May 1, 2019 16:47:18 GMT-0000 by admin. (Version 3)

Attached files

ID Name Comment Uploaded Size Downloads
11800 Linnea Huss_web_compressed.pdf PDF 2019 admin 23 Apr, 2019 16:06 2.16 Mb 9
11799 BC low Vitamin D poor VDR.jpg admin 23 Apr, 2019 16:04 22.03 Kb 33
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