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Bone density improved by monthly 50,000 IU of vitamin D for 6 months – RCT Jan 2021

Effect of vitamin D therapy on bone mineral density in patients with diabetic nephropathy; a randomized, double-blind placebo controlled clinical trial

Journal of Diabetes & Metabolic Disorders (2021) https://doi.org/10.1007/s40200-021-00737-y
Gayani Liyanage, Sarath Lekamwasam, Thilak Weerarathna & Chandrani Liyanage

Diabetes compromises bone strength resulting increased risk of osteoporosis. Objective of this study was to determine the effect of vitamin D given to patients with early diabetic renal disease on BMD and BMC.

Patients with diabetic nephropathy were recruited. Treatment group received 50,000 IU of vitamin D3 intramuscularly and the control group was given an equal volume of distilled water (0.25 mL) monthly for six months. Baseline BMD, BMC in the total body, lumbar spine and proximal femur were measured by DXA. After six months measurements were repeated. When trial period was over, a randomly selected subgroup of patients (25 from each group) was followed up for further six-months and measurements were repeated.

Selected patients were randomly assigned to two groups. After six months, the treatment group total body BMD, total body BMC and BMDs of spine, femoral neck and total hip regions increased by 2.0%, 2.2%, 1.8%, 2.1% and 2.6% (P < 0.05 for all within-group differences), respectively. In the Control group, BMD or BMC of any region mentioned above did not change significantly during the initial 6 months (P < 0.05 for the between-groups differences). After 6 months of stopping treatment, a statistically significant reduction of total BMD and BMC was observed in the treatment group (P = 0.009).

This study showed that treatment with high dose vitamin D significantly influences total body BMC, total body BMD, BMDs of spine, femoral neck and hip among patients with diabetic nephropathy.

Each of the following have been found to increase bone mineral density

  1. Enough of a good form of vitamin D for 6+ months (this study)
  2. Additonal vitamins and minerals which help grow bones (Magnesium, Calcium,silicon, etc)
  3. Stress on bones(exercise) to tell the body to increase the bone strength

Note: Bone Strength is a much better indicator of Bone Mineral Density, but is rarely available

Poor guts need different forms of vitamin D

Guesses of Vitamin D response if poor gut

Bio FormSpeedDuration
10Injection ($$$)
or Calcidiol or Calcitriol
D - Slow
C -Fast
10 Sun/UVBSlowLong
(skin patch/cream, vagina)
Fast nano
9Nanoemulsion -mucosal
perhaps activates VDR
9?Inhaled (future)FastNormal
8Bio-D-Mulsion ForteNormalNormal
6Water soluble (Bio-Tech)NormalNormal
(some goes into gut)
3Coconut oil basedSlowNormal
2Food (salmon etc.)SlowNormal
2Olive oil based (majority)SlowNormal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months

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Bone - Health category contains:

308 items in Bone - Health category
See also

VitaminDWiki -Weekly, Monthly Vitamin D are typically better than daily - many studies

Created by admin. Last Modification: Sunday March 17, 2024 19:06:01 GMT-0000 by admin. (Version 8)