Breast Cancer Research 201820:110, https://doi.org/10.1186/s13058-018-1035-6
Anthony J. Swerdlow, Lauren B. Wright, Minouk J. Schoemaker and Michael E. Jones
Vitamin D is NOT mentioned in the study
1) Longer pregnancy ==> consume more Vit D ==> lower Vit D ==> increased breast cancer
2) Poor receptor ==> longer pregnancy ==> heavier baby (speculation)
AND increased Breast Cancer (known)
- Diagnosed with breast cancer – take vitamin D to cut chance of death by half – July 2018
- Breast Cancer 80 percent less likely if high level of vitamin D – June 2018
- Breast Cancer was 4.6 times more likely if have a poor Vitamin D Receptor – Dec 2016
Overview Breast Cancer and Vitamin D contains the following summary and sections
- 16+ meta-analyses of Vitamin D and Breast Cancer
example: 2X reduction of deaths from Breast Cancer if have enough Vitamin D.
- Appears that having lots of Vitamin D will reduce by 3 X the chance of Breast Cancer
wonder just how much more proof is needed
- Breast Cancer 4X more likely if have poor genes
- Cancer - Breast category listing has
217 items along with related searches
Parity and age at first pregnancy are well-established risk factors for breast cancer, but the effects of other characteristics of pregnancies are uncertain and the literature is inconsistent.
In a cohort of 83,451 parous women from the general population of the UK, which collected detailed information on each pregnancy and a wide range of potential confounders, we investigated the associations of length of gestation and birthweight of offspring in a woman’s pregnancies with her breast cancer risk, adjusting for a full range of non-reproductive as well as reproductive risk factors unlike in previous large studies.
Gestation of the first-born offspring was significantly inversely related to the risk of pre-menopausal breast cancer (p trend = 0.03; hazard ratio (HR) for 26–31 compared with 40–41 weeks, the baseline group, = 2.38, 95% confidence interval (CI) 1.26–4.49), and was borderline significantly related to risk of breast cancer overall (p trend = 0.05). Risk was significantly raised in mothers of high birthweight first-born (HR for breast cancer overall = 1.53, 95% CI 1.06–2.21 for ≥ 4500 g compared with 3000–3499 g, the baseline group). For gestation and birthweight of most recent birth, there were no clear effects. Analyses without adjustment for confounders (other than age) gave similar results.
Our data add to evidence that short gestation pregnancies may increase the risk of breast cancer, at least pre-menopausally, perhaps by hormonal stimulation and breast proliferation early in pregnancy without the opportunity for the differentiation that occurs in late pregnancy. High birthweight first pregnancies may increase breast cancer risk, possibly through the association of birthweight with oestrogen and insulin-like growth factor 1 levels.
Their speculations in the discussion section of the PDF
- "Women giving birth to heavier offspring tend to have higher oestrogen and free oestrogen levels [8, 9, 12–14] and insulin-like growth factor 1 (IGF1) levels  in pregnancy, giving a plausible mechanism for an association of high birthweight of offspring with maternal breast cancer risk."
- "While hormonal and histological explanations for the relation of gestation and birthweight to breast cancer risk seem the most obvious, it is also possible that maternal genetic susceptibility loci affecting offspring birthweight  or gestation  may affect breast cancer risk."
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