Loading...
 
Toggle Health Problems and D

Birth rates doubled with Vitamin D - 300,000 for infertile men – RCT Nov 2017


Effects of vitamin D supplementation on semen quality, reproductive hormones and live birth rate: a randomized clinical trial.

J Clin Endocrinol Metab. 2017 Nov 3. doi: 10.1210/jc.2017-01656
Blomberg Jensen M1,2, Lawaetz JG1, Petersen JH1,3, Juul A1, Jørgensen N1.

  • 1 Department of Growth and Reproduction and International Research and Research Training Centre in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Denmark.
  • 2 Division of Bone and Mineral Research, HSDM/HMS, Harvard University, Boston MA, US.
  • 3 Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark.

Increased natural births after 300,000 IU

Image

Big increase in birth rates in men with low sperm count

Image
CONTEXT: Animal models and cross-sectional cohort studies have suggested a beneficial role for vitamin D in male reproduction.

OBJECTIVE: Determine the effect of vitamin D and calcium supplementation on semen quality in infertile men with serum 25-hydroxyvitamin-D (25OHD)≤ 50 nmol/l.

DESIGN: A single centre, triple-blinded, randomized clinical trial.

PARTICIPANTS: 1427 infertile men were screened to include 330. 1002 men did not meet inclusion criteria and 95 did not wish to participate.

INTERVENTION: The active group received cholecalciferol 300,000IU initially followed by 1400IU + 500 mg calcium daily for 150 days, while the other group received placebo.

RESULTS: Serum concentrations of 25-OHD and 1,25OH2D3 were significantly higher in men treated with vitamin D + calcium for 150 days compared with placebo. Vitamin D supplementation was not associated with changes in semen parameters although spontaneous pregnancies tended to be higher 7.3% vs 2.4% ,Δ5.0% [-0.6%;10.5%].
Vitamin D treatment in a subgroup of oligozoospermic men increased the chance for a live birth compared with placebo 35.6% vs 18.3%,Δ17.3% [1.6%; 32.9%]. Moreover, serum inhibin B was higher in vitamin D deficient men randomized to vitamin D 193 pg/ml vs 143 pg/ml, Δ49pg/ml [8;91pg/ml], however, the increase in sperm concentration was not significantly higher than placebo (p=0.07).

CONCLUSIONS: High dose vitamin D supplementation did not improve semen quality in vitamin D insufficient infertile men. The positive impact of vitamin D supplementation on live birth rate and serum inhibin B in oligozoospermic and vitamin D deficient men may be of clinical importance and warrant verification by others.
 Download the PDF from VitaminDWiki


Study was cited 120 times in Google Scholar as of Jan 2024

Google Scholar

  • Vitamin D supplementation for improving sperm parameters in infertile men: A systematic review and meta-analysis of randomized clinical trials 0 Jan 2023, https://doi.org/10.1080/2090598X.2023.2165232 FREE PDF
    • 5X increase in total sperm motility by vitamin d supplementation

See also VitaminDWiki


There have been 5328 visits to this page




Created by admin. Last Modification: Friday January 5, 2024 14:48:49 GMT-0000 by admin. (Version 18)
Birth rates doubled with Vitamin D - 300,000 for infertile men – RCT Nov 2017        
1618 visitors, last modified 05 Jan, 2024,
Printer Friendly Follow this page for updates

Attached files

ID Name Comment Uploaded Size Downloads
18036 low sperm count.jpg admin 04 Jul, 2022 42.64 Kb 333
18035 natural births.jpg admin 04 Jul, 2022 9.15 Kb 332
18034 birth rate 300,000 IU or men.pdf admin 04 Jul, 2022 857.13 Kb 204