Non-daily (Bolus) is virtually always better: -Reasons include:
- Better compliance
- Fewer opportunities to forget
- Fewer times to have to take a pill - for those who dislike it
- High concentration resulting from infrequent dosing gets past some gene and gut limitations
- Note: Many studies have found non-daily to be better than daily
I am unaware of a single study which has found daily to be better than non-daily - Founder of VitaminDWiki Dec 2019
- Note: Many studies have found non-daily to be better than daily
Table of contents
- Take vitamin D3 daily, weekly, or bi-weekly - many studies
- Better than Daily studies
- Examples of non-daily vitamin D studies (does not include loadng dose)
- Intervention - non daily AND Diabetes
- Intervention - non daily AND Pain
- Intervention - non daily AND Pregnancy
- Intervention - non daily AND Senors
- Intervention - non daily AND Infant-Child
- Intervention - non daily AND Obesity
- Daily lasting 14 weeks was beter than weekly landing only 8 weeks - June 2020
- Daily better than weekly - but used 70,000 total per week vs. 50,000 once a week - 2021
- Loading Dose in VitaminDWiki
- Better Than Daily category is associated with 6 other VitaminDWiki categories (>2 each)
Take vitamin D3 daily, weekly, or bi-weekly - many studies
- The Vitamin D Receptor is activated by high concentration gradient and 12+ other things
Better than Daily studies
- wiki page:
- Vitamin D treatment of Chronic Kidney Disease: monthly better than daily – RCT May 2022
- Vitamin D: Bolus is Bogus (if more than 17 days between oral doses) – Oct 2021
- Vitamin D loading dose was as effective as daily dosing (rickets in this case) – RCT July 2021
- 50,000 IU of Vitamin D once every 2 weeks achieved 40 ng in 3 months – RCT March 2021
- Stoss (loading) dose of vitamin D resulted in bigger response at 30 days (again) – RCT April 2021
- 44 percent of successful RCTs in VitaminDWiki used non-daily dosing - Nov 2020
- Diabetic inflammation reduced by Vitamin D (30,000 IU weekly) – RCT July 2020
- IBS diarrhea treated by weekly 50,000 IU of Vitamin D – RCT March 2020
- 20,000 IU of Vitamin D weekly gave many benefits – RCT Aug 2019
- How I am reminded to take my Vitamin D once every 4 days
- Yet another study confirms Depression is treated by weekly Vitamin D (50,000 IU)– RCT Dec 2019
- Better than Daily
- Vitamin D dosing - weekly may be better than daily – video Aug 2018
- Monthly 100,000 IU of vitamin D is safe (and may be better than daily) – RCT Aug 2018
- Vitamin D given weekly better than daily (Nursing home, 5,600 IU weekly) – Aug 2018
- Vitamin D every 25 days may be BETTER than daily – RCT May 2018
- Monthly vitamin D dosing had higher response than 3 per month – RCT Jan 2018
- Monthly vitamin D dosing is better than daily dosing for children and elderly (more likely to be taken) – June 2017
- Optimal vitamin D supplementation strategies (D3 - weekly or monthly) – Feb 2017
- Vitamin D – monthly dosing was better than daily with Calcium – RCT Dec 2015
- Can get 50,000 IU Vitamin D anywhere on the globe
- Take vitamin D3 daily, weekly, or bi-weekly
Examples of non-daily vitamin D studies (does not include loadng dose)
One pill every two weeks gives you all the vitamin D most adults need
50,000 IU of vitamin D every two weeks – Jordan conclusion - RCT July 2017
22 diseases proven to be prevented/treated by biweekly Vitamin D
10 additional diseases with weekly Vitamin D
Intervention - non daily AND Diabetes
- Diabetes synergistically treated by Vitamin D plus Aerobic exercise – RCT June 2022
- One vitamin D pill every 4 weeks should cost-effectively reduce diabetes in Iran – Jan 2022
- Most Diabetics getting 40,000 IU of vitamin D weekly did not get to 30 ng (needed gut-friendly form) - RCT June 2020
- Diabetes helped somewhat by weekly 50,000 IU of vitamin D (5 ways to improve) – RCT Aug 2021
- Prediabetes reduced by weekly 60,000 IU of Vitamin D – RCT Jan 2021
- Diabetic inflammation reduced by Vitamin D (30,000 IU weekly) – RCT July 2020
- 100,000 IU of Vitamin D3 monthly for 4 months to diabetics (D2 bombed) – RCT Dec 2019
- Type 2 Diabetes inflammation reduced by 50,000 IU of Vitamin D bi-weekly and resistance training – RCT – June 2019
- Prediabetes both prevented and treated by monthly Vitamin D, etc.
- Peripheral diabetic neuropathy helped by weekly 50,000 IU vitamin D – Jan 2019
- Diabetic nephropathy (Kidney) treated by 50,000 IU of vitamin D weekly – RCT Jan 2019
- Vitamin D treatment of diabetes (50,000 IU every 2 weeks) augmented by probiotic – RCT June 2018
- Waist size reduced 3 cm by Vitamin D in those with Metabolic Syndrome – Jan 2017
- HbA1c levels (Diabetes) reduced by monthly 50,000 IU of vitamin D – Dec 2017
- Gestational Diabetes treated with 50,000 IU every two weeks – RCT Sept 2016
- Prediabetes reduced by monthly 60,000 IU of vitamin D – RCT May 2015
- Pain of Diabetic Neuropathy reduced with weekly 50,000 IU vitamin D– CT Feb 2015
- Type 1 diabetes helped with 50,000 IU of vitamin D every two weeks – Nov 2014
- Gestational Diabetes reduced with 50,000 IU of vitamin D every 3 weeks and daily Calcium – RCT June 2014
- Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT Jan 2014
- 50,000 IU Vitamin D weekly Improves Mood, Lowers Blood Pressure in Type 2 Diabetics – Oct 2013
- Insulin resistance during pregnancy improved with 50,000 IU of vitamin D every 2 weeks – RCT April 2013
Intervention - non daily AND Pain
- Pain reduced by Vitamin D (60K weekly, then monthly) plus daily Calcium in 3 months – May 2021
- Rheumatoid Arthritis pain reduced by monthly 100,000 IU of Vitamin D – Oct 2018
- Fibromyalgia pain substantially reduced by weekly Vitamin D (50,000 IU) – June 2018
- 100,000 IU of vitamin D monthly decreases use of NASIDs by 13 percent if low vitamin D – RCT May 2018
- Knee osteoarthritis pain reduced by 60,000 IU monthly vitamin D following loading dose – RCT Nov 2013
- Fibromyalgia treated with Vitamin D (50,000 IU weekly for 3 months) – 2016, 2017, 2018, 2019
- Knee osteoarthritis treated with vitamin D, weekly 50,000 IU – May 2015
- Pain of Diabetic Neuropathy reduced with weekly 50,000 IU vitamin D– CT Feb 2015
- Angina dramatically reduced by injections of vitamin D twice a month (300,000 IU) – Jan 2015
- Growing pains reduced 60 percent by monthly Vitamin D – March 2014
- Fibromyalgia pain with trazodone reduced by 50 percent with weekly 50,000 IU of vitamin D – RCT Nov 2014
- 7 improvements in lives of veterans with chronic pain with 50,000 IU vitamin D weekly – June 2012
- Raynaud's pain decreased with 600,000 IU monthly vitamin D – RCT May 2012
Intervention - non daily AND Pregnancy
- Weekly Vitamin D to mother after birth much better than daily - RCT Aug 2018
- Pregnancies helped a lot by Vitamin D (injection then 50,000 IU monthly) – RCT May 2018
- 300,000 IU of Vitamin D is not enough during pregnancy – RCT May 2018
- Monthly 120,000 IU Vitamin D plus daily Calcium was great during pregnancies – RCT Sept 2017
- Preeclampsia recurrence reduced 2 X by 50,000 IU of vitamin D every two weeks – RCT July 2017
- 50,000 IU of vitamin D for 8 weeks of pregnancy raised most above 30 nanograms - RCT Jan 2017
- Gestational Diabetes treated with 50,000 IU every two weeks – RCT Sept 2016
- Pregnancy – adding 35,000 IU Vitamin D weekly was nice, but not enough – RCT April 2016
- Preeclampsia reduced by Vitamin D (50,000 IU bi-weekly) and Calcium – Oct 2015
- No multiple sclerosis relapses during pregnancy if 50,000 IU of Vitamin D weekly – RCT April 2015
- 50,000 IU of Vitamin D every 2 weeks reduced gestational diabetes – RCT Feb 2015
- Gestational Diabetes reduced with 50,000 IU of vitamin D every 3 weeks and daily Calcium – RCT June 2014
- Breast milk resulted in 20 ng of vitamin D for infant if mother had taken 5,000 IU daily – RCT Dec 2013
- Prenatal Vitamin D (35,000 weekly, 3rd trimester) resulted in 1 cm taller infants at age 1 year – RCT Aug 2013
- Insulin resistance during pregnancy improved with 50,000 IU of vitamin D every 2 weeks – RCT April 2013
- Near the end of pregnancy 50,000 IU vitamin D weekly was great – RCT April 2013
- 35,000 IU vitamin D weekly during 3rd quarter pregnancy – RCT March 2013
Intervention - non daily AND Senors
- 50,000 IU Vitamin D weekly was the most popular for Breast Cancer - May 2020
- Response by obese to weekly 50,000 IU of Vitamin D – May 2018
- Chinese women in tropics needed 50,000 IU of Vitamin D monthly to keep above 30 ng – RCT May 2017
- 50,000 IU of vitamin D every two weeks – Jordan conclusion - RCT July 2017
- Many benefits of 50,000 IU vitamin D every two weeks (methadone treatment) – RCT June 2017
- Children getting 60,000 IU monthly got to vitamin D level of 33 ng – Sept 2015
- Response and adverse effects of 20,000 and 30,000 IU Vitamin D weekly - Feb 2015
- One pill every two weeks gives you all the vitamin D most adults need
- 7100 IU (50000 weekly) got most women to 30 ng of vitamin D - Aug 2012
- Take vitamin D3 daily, weekly, or bi-weekly
- Muscle strength in youth increased with 60,000 IU vitamin D per week and 1 g Calcium – April 2010
Intervention - non daily AND Infant-Child
- Vitamin D for infants – 100,000 IU monthly is better than 400 IU daily – RCT Oct 2020
- Vitamin D levels in children optimized with six Vitamin D biscuits – RCT Nov 2018
- Breastfeeding mothers and Vitamin D: supplement only themselves usually, 4 out of 10 used monthly rather than daily – Jan 2017
- Vitamin D required for breastfed infants – daily or monthly, infant or mother – Jan 2017
- Mother got 100,000 IU of vitamin D monthly, breastfeeding infant got a little – RCT Aug 2016
- Infant infection reduced by half with vitamin D supplementation – RCT May 2016
- Children getting 60,000 IU monthly got to vitamin D level of 33 ng – Sept 2015
- Type 1 diabetes helped with 50,000 IU of vitamin D every two weeks – Nov 2014
- Growing pains reduced 60 percent by monthly Vitamin D – March 2014
- Breast milk resulted in 20 ng of vitamin D for infant if mother had taken 5,000 IU daily – RCT Dec 2013
Intervention - non daily AND Obesity
- 20,000 IU of Vitamin D weekly gave many benefits – RCT Aug 2019
- Obese lost 3X more weight with Vitamin D - July 2018
- Severely Obese not helped much by 50,000 IU of vitamin D weekly for 8 weeks – RCT June 2019
- Obese responded to weekly vitamin D better than non-obese – RCT March 2018
- Daily, monthly Vitamin D had similar great benefits, more than 6 months needed – RCT Dec 2018
- Obese lost more weight on diet if added 50,000 IU of vitamin D weekly – many RCTs
- Response by obese to weekly 50,000 IU of Vitamin D – May 2018
- Waist size reduced 3 cm by Vitamin D in those with Metabolic Syndrome – Jan 2017
- 5,000 IU daily or 50,000 IU Vitamin D weekly repleted many dark skinned adolescents – RCT Dec 2015
- 50,000 IU vitamin D 1-3 times per week helped obese patients in rehab. – May 2013
Some people believe that daily Vitamin D dosing is needed while breastfeeding or supplementing infants
However, it turns out that infants, like all humans and animals, can store Vitamin D, which is necessary to exist in rainy seasons, etc.
Daily lasting 14 weeks was beter than weekly landing only 8 weeks - June 2020
Daily oral vitamin D3 regimen in similar cumulative doses is more effective than weekly oral vitamin D3 regimen in patients with vitamin D deficiency
Note: Weekly lasted only 8 weeks, daily lasted for 14 weeks
Download the PDF from VitaminDWiki
Daily better than weekly - but used 70,000 total per week vs. 50,000 once a week - 2021
Vitamin D supplementation: better daily or by bolus?
Download the PDF from VitaminDWiki
Loading Dose in VitaminDWiki
- Overview Loading of vitamin D - which is sometimes just a single dose
- Loading dose for Vitamin D category listing has
188 items along with related searches - Loading doses typically restore Vitamin D levels in 1 to 30 days
- Loading doses should be followed by maintenance doses - which can be daily or bolus
Better Than Daily category is associated with 6 other VitaminDWiki categories (>2 each)
Click here for association information
Summary of Associations
Associated category Associations Results
17 pages in both categories: Better than daily + Intervention - non daily
2 pages in both categories: Better than daily + How much Vitamin D
Page Hits Categories Major change Take vitamin D3 daily, weekly, or bi-weekly 16786 How much Vitamin D, Intervention - non daily, Better than daily 08 Mar, 2021 How I am reminded to take my Vitamin D once every 4 days 1907 How much Vitamin D, How, when to take Vit. D, Better than daily 05 Jan, 2020 13 pages in both categories: Better than daily + Intervention
4 pages in both categories: Better than daily + Loading dose for Vitamin D
2 pages in both categories: Better than daily + Optimum
3 pages in both categories: Better than daily + How, when to take Vit. D
4 pages in both categories: Better than daily + Top news
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