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Baggy eyes in seniors (dermatochalasis) is associated with low vitamin D – July 2024

Relationship between histopathological findings of patients with dermatochalasis and vitamin D deficiency

International Ophthalmology Volume 44, # 309, (2024) https://doi.org/10.1007/s10792-024-03209-3 References are online
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Emre Aydemir, Emine Malkoç Şen, Gözde Aksoy Aydemir, Alper Halil Bayat, Ali Karnaz & Bilge Aydın Türk



Larger lymph vessels associated with lower Vitamin D
To compare the histopathological findings of patients who had been diagnosed with dermatochalasis (DC) and had undergone upper eyelid blepharoplasty (ULB) as well as those of controls (C-Group) according to their serum vitamin D (SVD) levels.

The prospective study included 136 upper eyelid skin from 68 patients who underwent surgery for DC and 53 upper eyelid skin from 53 patients who underwent levator surgery with ULB. The DC Group was then divided into 3 subgroups according to the marginal reflex distance (MRD4). The lymphatic vessel (LV) count and diameter of the largest LV (DLLV) were recorded, the stromal collagen bed (SCB) was observed, and its depth was measured, the interfibrillar edema was examined, and the elastic fiber and macrophage counts and recorded, respectively, and then all of these were evaluated. The SVD levels were compared between the DC patients and the C-Group.

In comparison to the C-Group, significant changes were seen in the dilated LV, DLLV, SCB depth, interfibrillar edema, elastic fiber density, and macrophage count in the DC sub-Groups (P < 0.001 for all). While no difference was found between DC sub-Group 1 (MRD4 > 4 mm) and the C-Group (P > 0.05), a significant difference was found between DC sub-Group 2 (MRD4 2–4 mm) and DC sub-Group 3 (MRD4 < 2 mm) for all of the parameters (P < 0.05). A statistically significant difference was also found in the SVD levels between the DC sub-Group 1 and DC sub-Groups 2–3 (P < 0.017, P < 0.001 respectively).

According to the results of this study, SVD level was significantly lower in DC group. Moreover, an increased LV count and diameter, decreased elastic fiber count, collagen fiber and stromal edema irregularity, and increased macrophage count were found to be associated with the SVD level.

Evaluation of 25-Hydroxyvitamin D levels in patients with dermatochalasis - Aug 2023

International Ophthalmology Vol 43, pages 749–756, (2023) https://doi.org/10.1007/s10792-022-02474-4
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Sevim Ayça Seyyar & Ecem Onder Tokuc

To compare serum 25-hydroxyvitamin D (25(OH)D) levels of patients with dermatochalasis who underwent upper lid blepharoplasty and healthy controls.

This retrospective comparative study included dermatochalasis patients who underwent upper lid blepharoplasty and age-and sex-matched controls from January 2019 to January 2021. The data, including comprehensive ophthalmological examination, internal medicine outpatient examination, and laboratory results of the dermatochalasis patients and healthy controls, were collected from the electronic patient records. Serum 25(OH)D, creatinine, calcium (Ca), phosphate (P), triglyceride (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels were evaluated and compared between the dermatochalasis patients and healthy controls.

Of our participants, consisting of 46 patients with dermatochalasis and 52 healthy controls, 54 (55.10%) were female and 44 (44.90%) were male. A statistically significant difference was observed in vitamin D levels between the healthy and dermatochalasis groups (p ≤ 0.001). The percentage of individuals with vitamin D deficiency (< 20 ng/mL) was significantly higher in the dermatochalasis group (p = 0.001). In addition, the percentage of individuals with severe vitamin D deficiency (< 10 ng/mL) was again significantly higher in the dermatochalasis group (p = 0.001).
The risk of dermatochalasis incidence was found to increase in cases of low vitamin D (OR = 1.210; p = 0.017).

Low serum 25(OH)D levels may play a role in the etiopathogenesis of dermatochalasis. Future research should include longitudinal studies and prospective clinical studies to investigate the mechanism responsible for the low vitamin D observed in dermatochalasis patients.

Floppy Eye Syndrome (Chapter in Dry Eye book) - 2019

Attached files

ID Name Comment Uploaded Size Downloads
21402 Baggy time of year.webp admin 06 Jul, 2024 19.85 Kb 21
21401 Lymphatic size.webp admin 06 Jul, 2024 6.78 Kb 22
21400 Baggy table.webp admin 06 Jul, 2024 35.10 Kb 37
21399 Baggy eyes.webp admin 06 Jul, 2024 17.94 Kb 35