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BMI decreased by Vitamin D (none of the trials used enough D for long enough) – meta-analysis July 2019

Is Vitamin D Supplementation Useful for Weight Loss Programs? A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Medicina 2019, 55(7), 368; https://doi.org/10.3390/medicina55070368
Simone Perna
Department of Biology, College of Science, University of Bahrain, Sakhir Campus P. O. Box 32038, Bahrain
(This article belongs to the Special Issue The Role of Vitamin D in Obesity)


To lose weight many studies have found the need to:

  1. Take a minimum of 4,000 IU daily average
  2. Take it weekly or bi-weekly, not daily
  3. Take it for at least 4 months
  4. Have Vitamin D be a part of an exercise and/or calorie reduction program

Obesity is associated with low Vitamin D (and treated by D as well) – Aug 2019 has the following

Fast weight loss by Obese: Summary of the data as of Sept 2019
1) 50,000 IU Vitamin D weekly for at least 6 months
   If gut problems, should use a gut-friendly form of vitamin D
2) Add calorie restriction diet and light exercise after ~2 months*
   * Vitamin D levels must be above 30ng/ml to help with weight loss
   * Can start losing weight 2 months sooner if take a 50,000 IU daily for a week (400,000 IU)
3) More weight loss if also add Magnesium or cofactors
Magnesium: 30% Improved Vitamin D response with Magnesium - a Vitamin D Cofactor
   Note: Magnesium reduces weight loss by itself as well
  Omega-3: 20% improved vitamin D response if also add Omega-3 a Vitamin D Cofactor
  Note: Omega-3 reduces weight loss by itself as well
4) More weight loss if also improve activation of Vitamin D Receptor
   Vitamin D Receptor activator provides 0-30% improved Vitamin D response))
   Obesity 1.5 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2019

 Download the PDF from VitaminDWiki

Background and Objectives: The controversy about the impact of vitamin D supplementation on weight loss treatment was observed in several randomized controlled trials (RCTs). This meta-analysis investigates the effects of vitamin D supplementation (cholecalciferol or ergocalciferol) on weight loss through holistic measurements of Body Mass Index (BMI), weight and waist circumference.

Materials and Methods: Google Scholar, WOS, PubMed and Scopus were explored to collect relevant studies. The selected articles focused on vitamin D supplementation in overweight and obese individuals with different conditions. Eleven RCTs were included into this meta-analysis with a total of 947 subjects, with a mean of the follow-up from 1 to 12 months and different vitamin D interventions (from 25,000 to 600,000 IU/monthly of cholecalciferol). Results:
The meta-analyzed mean differences for random effects showed that cholecalciferol supplementation deceases the

  • BMI by –0.32 kg/m2 (CI95% –0.52, –0.12 kg/m2, p = 0.002) and the
  • waist circumference by –1.42 cm (CI95% –2.41, –0.42 cm, p = 0.005),

but does not statistically affect weight loss –0.43 kg (CI95% –1.05, +0.19 kg, p = 0.17).

Conclusions: This meta-analysis lays the foundation for defining the potential clinical efficacy of vitamin D supplementation as a potential therapeutic option for weight loss programs, but further studies are needed to confirm the validity of these findings and delineate potential underlying mechanisms.

Created by admin. Last Modification: Monday September 9, 2019 21:58:31 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
12307 BMI Meta.jpg admin 12 Jul, 2019 15:47 44.30 Kb 59
12306 medicina-55-00368.pdf PDF 2019 admin 12 Jul, 2019 15:34 506.74 Kb 27
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