Table of contents
- Autism 10X less likely if a good Vitamin D Receptor - Feb 2020
- Autism 2X more likely if poor Vitamin D Receptor (yet again) – meta-analysis Jan 2020
- Association of polymorphisms in the vitamin D receptor gene and serum 25-hydroxyvitamin D levels in children with autism spectrum disorder - May 2016
- Autism risk increased 2 X or 2.6 X with poor Vitamin D receptors – Sept 2017
- Autism risk increased 1.95 X if poor VDR - Jan 2018
- Autism rate in siblings reduced 4X by vitamin D: 5,000 IU during pregnancy, 1,000 IU to infants – Feb 2016
- Vitamin D Receptor category listing has
366 items along with related searches
Vitamin D Receptor activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators
Autism category in VitaminDWiki starts withAutism category has
- Most Autism Risk factors are associated with low vitamin D - March 2014
- Rickets – 26 percent had autism: no rickets, no autism (both associated with low vitamin D) – June 2015
- Premature birth 2.5X more likely if mother had low vitamin D and was having twins – July 2013
- Autism 3X more likely after closely spaced pregnancy vs 3 year apart– Jan 2011
- Having twins takes more vitamin D - May 2011
Autism treated by Vitamin D
- Autism treated by Vitamin D (monthly injection of 150,000 IU) – June 2017
- Autism decreased in 8 out of 10 children supplemented with vitamin D – April 2015
Autism reduced by vitamins before and during pregnancy
- Autism risk reduced 2X by prenatal vitamins (Vitamin D or Folic) – Feb 2019
- Women who had supplemented with any vitamins were 6 X less likely to have autistic offspring – Jan 2018
- Autism rate cut in half when multivitamins (including vitamin D) used during pregnancy – Oct 2017
- Autism rate in siblings reduced 4X by vitamin D: 5,000 IU during pregnancy, 1,000 IU to infants – Feb 2016
Autism and Vitamin D Receptor (not enough Vit D to the tissues)
- Autism associated with low Zinc during pregnancy (Zinc is needed by Vitamin D Receptor) – July 2018
- Autism 2X more likely with Vitamin D Receptor problems – many studies
Autism - other risk factors
- Autistic symptoms reduced by Vitamin D and or Omega-3 – RCT March 2019
- Omega-3 probably can decrease Autism and ADHD – March 2019
- Autism risk increased if infant had antibiotics (2X), acetaminophen (3X), or no vitamin D drops (1.5X) – June 2018
- 20 X more Parkinson's and 100X more Autism with GMO soy in China
- Note >100X increase in Autism while having GMO soy in the US
Vaccines increase the risk
- Does a vaccine increase the risk of Autism – March 2019
- Autism 2.75 X more likely in Hib vaccines containing Mercury – May 2018
- Autism and ADHD type disorders were 14X more likely in survey of extreme preterm vaccinated infants - April 2017
- Off topic: CDC deleted a 3X increase in black male autism due to vaccination – whistle blowing Aug 2014
Dr. Cannell on Autism and Vitamin D
- Autism treated by Vitamin D (80 – 120 ng) – Cannell update May 2018
- Autism Causes, Prevention and Treatment: Vitamin D Deficiency etc. – Book April 2015 Cannell
- Autism cured in a child with Vitamin D, Dr. Cannell comments and cofactor recommendations – March 2015
- Autism and Vitamin D - Dr. Cannell in Life Extension Mag - Jan 2014
- Autism treated by Vitamin D: Dr. Cannell - video June 2013
- includes his list of 27 reasons to associate Vitamin D with Autism in 2013
Vitamin D Receptor Polymorphisms Associated With Autism Spectrum Disorder
Autism Res, 2020 Feb 21 DOI: 10.1002/aur.2279
Franca Rosa Guerini 1, Elisabetta Bolognesi 1, Matteo Chiappedi 2, Maria Martina Mensi 2, Oscar Fumagalli 1, Chiara Rogantini 2, Milena Zanzottera 1, Alessandro Ghezzo 3, Michela Zanette 1, Cristina Agliardi 1, Andrea Saul Costa 1, Stefano Sotgiu 4, Alessandra Carta 4 5, Nasser Al Daghri 6, Mario Clerici 1 7
Vitamin D is endowed with a number of biological properties, including down-regulation of inflammation, and might contribute to the pathogenesis of autism spectrum disorders (ASD). Vitamin D binds to the vitamin D Receptor (VDR); the biological activity of the ensuing complex depends on VDR FokI, BsmI, ApaI, and TaqI gene polymorphisms. We evaluated such Single Nucletoide Polymorphismsm (SNPs) in a cohort of 100 Italian families with ASD children. FokI genotype distribution was skewed in ASD children compared with their healthy sibs (Pc = 0.03 2 df) and to a group of 170 Italian healthy women (HC) (Pc = 0.04 2 df). FokI genotype and allelic distribution skewing were also observed in mothers of ASD children compared to HC (Pc = 0.04 2 df). Both Transmission Disequilibrium Test for single loci and haplotype analysis distribution revealed a major FokI (C) allele-mediated protective effect, which was more frequently transmitted (73%) than not transmitted to healthy sibs (P = 0.02).
A protective FokI-, BsmI-, ApaI-, and TaqI (CCAG) haplotype was more frequently carried by healthy sibs than by ASD children (P = 1 × 10-4 ; OR: 0.1, 95% CI: 0.03-0.4) too. Finally, a strong gene-dose association of FokI (T) allele with both higher Childhood Autism Rating Scale score (Pc = 0.01) and, particularly, with hyperactivity behavior (Pc = 0.006) emerged in ASD children. Because the protein produced by the FokI (T) allele is transcriptionally less active than that produced by the FokI (C) allele, the reduced biological activity of the vitamin D/VDR complex prevalent in ASD could favor ASD- and maternal immune activation- associated inflammation. Vitamin D supplementation might be useful in preventative and rehabilitation protocols for ASD.
LAY SUMMARY: Vitamin D deficiency and Vitamin D receptor (VDR) polymorphisms are associated with structural and functional brain abnormalities and behavioral disorders. We analyzed the association of VDR gene polymorphisms in a cohort of 100 Italian families with ASD children. A strong correlation between one of the VDR polymorphisms and hyperactivity behavior was evidenced in ASD children. In healthy mothers, the same VDR polymorphism was also correlated with an increased risk of giving birth to children with ASD
Association of polymorphisms in the vitamin D receptor gene and serum 25-hydroxyvitamin D levels in children with autism spectrum disorder - May 2016
Gene, Available online 4 May 2016, doi:10.1016/j.gene.2016.05.004
Salih Coşkun a, , scoskun9 at gmail.com, Şeref Şimşek b, M.Akif Camkurt c, Abdullah Çim a, Sercan Bulut Çelik d
a Dicle University, Medical School, Department of Medical Genetics, Diyarbakır, Turkey
b Dicle University, Medical School, Department of Child Psychiatry, Diyarbakır, Turkey
c Afşin State Hospital, Psychiatry Department, Kahramanmaraş, Turkey
d Family health center, Batman, Turkey
- There was significantly association between TaqI, BsmI and FokI polymorphisms and ASD susceptibility.
- The haplotype GTTT was found to confer 2.32-fold risk for ASD compared to controls.
- We found significantly higher serum 25(OH)D levels in ASD patients than controls.
- We showed an association between FokI polymorphism and serum 25(OH)D levels in ASD patients.
Vitamin D is implicated in several aspects of human physiology, and polymorphisms in the vitamin D receptor gene (VDR) are associated with a variety of neuropsychiatric disorders. The aims of this study are to determine whether VDR polymorphisms are associated with autism spectrum disorder (ASD), to examine serum 25-hydroxyvitamin D (25(OH)D) levels in ASD, and to explore whether VDR polymorphisms influence serum 25(OH)D levels. We investigated 480 subjects (237 children with ASD and 243 healthy controls) for the following VDR polymorphisms: TaqI, BsmI, FokI, ApaI, and Cdx2.Within the same samples, 25(OH)D levels were available only for 85 patients and 82 controls. The Cdx-2 variation was shown to deviate from Hardy–Weinberg equilibrium in the controls and was therefore excluded from the study.
We found that the frequency of rare
- FokI TT,
- TaqI CC, and
- BsmI AA genotypes
differed significantly between children with ASD and the controls (p = 0.042, p = 0.016, p = 0.038, respectively).
After correction for multiple testing, only the TaqI CC genotype remained significant. Further analysis using a recessive model showed that rare genotypes of these polymorphisms were significantly higher in patients compared to controls (p = 0.045, p = 0.005 and p = 0.031, respectively). However, no significant association was found between ApaI and ASD.
We found serum 25(OH)D levels to be significantly higher in children with ASD (p < 0.001) and that the FokI polymorphism had an effect on serum 25(OH)D levels in children with ASD (p = 0.041).
Additionally, we found the haplotype GTTT (BsmI/TaqI/FokI/ApaI) conferred an increased risk for developing ASD (p = 0.022; odds ratio [95% confidence interval]=2.322 [1.105–4.879]). This is the first clinical study evaluating the association between serum 25(OH)D levels and VDR polymorphisms in children with ASD. Our results demonstrated a significant association between TaqI, BsmI, and FokI polymorphisms and ASD and showed for the first time that FokI polymorphisms and haplotype GTTT (BsmI/TaqI/FokI/ApaI) are associated with an increased risk of ASD. Our findings support the hypothesis that 25(OH)D is involved in the pathophysiology of autism and that serum 25(OH)D levels may be affected by FokI polymorphisms in children with ASD. Our results should be considered as preliminary and needs confirmation by future studies.
Abbreviations: VDR, Vitamin D receptor gene; ASD, Autism Spectrum Disorder; 25(OH) D, 25-hydroxyvitamin D; HWE, Hardy–Weinberg equilibrium; SNP, Single nucleotide polymorphism; MS, Multiple sclerosis
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Vitamin D Receptor Gene Polymorphisms Associated with Childhood Autism
Brain Sci. 2017, 7(9), 115; Published: 9 September 2017 doi:10.3390/brainsci7090115 (registering DOI)
Anna Cieślińska 1, Elżbieta Kostyra 1, Barbara Chwała 2, Małgorzata Moszyńska-Dumara 3, Ewa Fiedorowicz 1, Małgorzata Teodorowicz 4 and Huub F.J. Savelkoul 4,* OrcID
1 Faculty of Biology and Biotechnology, University of Warmia and Mazury, 10-719 Olsztyn, Poland
2 Regional Children’s Hospital in Olsztyn, 10-719 Olsztyn, Poland
3 Center for Diagnosis, Treatment and Therapy of Autism at the Regional Children’s Hospital in Olsztyn, 10-719 Olsztyn, Poland
4 Cell Biology and Immunology Group, Wageningen University& Research, P.O. Box 338, 6700 AH Wageningen, The Netherlands
Background: Autism spectrum disorder (ASD) is a group of heterogeneous, behaviorally defined disorders whereby currently no biological markers are common to all affected individuals. A deregulated immune response may be contributing to the etiology of ASD. The active metabolite of vitamin D3 has an immunoregulatory role mediated by binding to the vitamin D receptor (VDR) in monocyte, macrophages, and lymphocytes. The effects of vitamin D and interaction with the VDR may be influenced by polymorphism in the VDR gene.
Methods: Genetic association of four different VDR polymorphisms (Apa-I, Bsm-I, Taq-I, Fok-I) associated with susceptibility to the development of autism in children was investigated.
Results: We uniquely found an association between the presence of the T allele at position Taq-I and presence of the a allele at position Apa-I of the VDR gene with decreased ASD incidence. There was also an association between female gender and the presence of the T allele. We found no statistical significant correlation between VDR single nucleotide polymorphisms (SNPs) and vitamin D3 concentration in serum of ASD children.
Conclusion: Genetic polymorphism in two SNP in VDR may be correlated with development of ASD symptoms by influencing functionality of vitamin D3 metabolism, while vitamin D3 levels were not significantly different between ASD and non-ASD children. View Full-Text