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Atopic dermatitis reduced with 1600 IU of vitamin D plus vitamin E – July 2011


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Intervention AND Skin in VitaminDWiki

Inflamation AND Skin in VitaminDWiki


Atopic dermatitis treatment needs more than 5,000 IU of Vitamin D – RCT Sept 2018

Oral vitamin D3 5000 IU/day as an adjuvant in the treatment of atopic dermatitis: a randomized control trial
Intenational Journal of Dermatology 20 September 2018 https://doi.org/10.1111/ijd.14220
Karen Sánchez‐Armendáriz MD Ana García‐Gil MD Cesar A. Romero MD José Contreras‐Ruiz MD Marcia Karam‐Orante MD

VitaminDWiki

Even when taking 5,000 IU of vitamin D 80% of AD had < 20 ng at 12 weeks

PDF is available free at Sci-Hub   10.1111/ijd.14220
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Background:Vitamin D has immunomodulatory effects both in the innate and adaptive immune systems, and there is growing scientific evidence demonstrating its relevance in inflammatory processes such as AD.

Hypothesis: If vitamin D3 promotes the skin immune system, then it should improve the response to treatment of patients with AD.

Methods
A randomized, double‐blind placebo‐controlled clinical trial was conducted, which included 65 patients with AD according to Hanifin–Rajka criteria and the severity scale (SCORAD). The patients were divided into two groups to receive either vitamin D3 5000 IU/day (n = 33) or placebo (n = 32), plus baseline therapy (topical steroid, soap substitute, and emollient) during 3 months.

Results
Fifty‐eight of the 65 enrolled subjects were included in the analysis. At the end of the intervention, the treated group achieved higher levels of 25(OH)D (P < 0.001). At week 12, those patients who registered serum levels of 25(OH)D ≥20 ng/ml, regardless of whether or not they had received supplementation, showed a lower SCORAD compared to those with levels <20 ng/ml (P < 0.001). Eighty percent of the patients with serum levels <20 ng/ml (n = 9) had moderate–severe AD despite standard treatment. Vitamin D levels ≥20 ng/ml associated with baseline therapy strongly favored remission of atopic dermatitis (P = 0.03). No significant differences were found between patients with serum levels of ≥20 ng/ml vs. ≥30 ng/ml.

Conclusions: Reaching serum levels of 25(OH)D > 20 ng/ml in conjunction with standard therapy is sufficient to achieve a reduction in severity (SCORAD) in patients with AD.


Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis - July 2011

J Dermatolog Treat. 2011 Jun;22(3):144-50. Epub 2010 Jul 24.
Javanbakht MH, Keshavarz SA, Djalali M, Siassi F, Eshraghian MR, Firooz A, Seirafi H, Ehsani AH, Chamari M, Mirshafiey A.
Department of Nutrition and Biochemistry, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

VitaminDWiki Summary
  • Vitamin D appears to both prevent and treat many skin diseases, such as atopic dermatitis
  • Topical vitamin D is especially useful for Skin diseases
      - as vitamin D is directed at the problem, rather than the whole body


BACKGROUND: Atopic dermatitis is a chronically relapsing, highly pruritic and inflammatory skin disease. This study was done to assess the effects of vitamins D and E supplementation on the clinical manifestation of atopic dermatitis.

METHODS: Forty-five atopic dermatitis patients were included in a randomized, double-blind, placebo-controlled trial. They were randomly divided into four groups and treated for 60 days: group P (n = 11), vitamins D and E placebos; group D (n = 12), 1600 IU vitamin D(3) plus vitamin E placebo; group E (n = 11), 600 IU synthetic all-rac-?-tocopherol plus vitamin D placebo; and group DE (n = 11), 1600 IU vitamin D(3) plus 600 IU synthetic all-rac-?-tocopherol. Serum 25(OH) vitamin D and plasma ?-tocopherol were determined before and after the trial. The clinical improvement was evaluated with SCORing Atopic Dermatitis (SCORAD). Data were analyzed by analysis of variance (ANOVA) and Kruskal-Wallis tests.

RESULTS: SCORAD was reduced after 60 days in groups D, E and DE by 34.8%, 35.7% and 64.3%, respectively (p = 0.004). Objective SCORAD also showed significant improvement. There was a positive correlation between SCORAD and intensity, objective, subjective and extent (p < 0.001). We found a significant negative association between plasma ?-tocopherol and SCORAD, intensity, objective and extent (p = 0.02).

CONCLUSION: This study supports the contributing and beneficial effects of vitamins D and E in the treatment of atopic dermatitis.
PMID: 20653487


What is the difference between atopic dermatitis and eczema?

MedicineNet
Eczema is used as a general term for many types of skin inflammation (dermatitis) and allergic-type skin rashes. There are different types of eczema, like allergic, contact, irritant, and nummular eczema. Several other forms have very similar symptoms. The diverse types of eczema are listed and briefly described below. Atopic dermatitis is typically a more specific set of three associated conditions occurring in the same person including eczema, allergies, and asthma. Not every component has to be present at the same time, but usually these patients are prone to all of these three related conditions.

Types of eczema

  • Contact eczema: a localized reaction that includes redness, itching, and burning where the skin has come into contact with an allergen (an allergy-causing substance) or with an irritant such as an irritating acid, a cleaning agent, or other chemical
  • Allergic contact eczema: a red, itchy, weepy reaction where the skin has come into contact with a substance that the immune system recognizes as foreign, such as poison ivy or certain preservatives in creams and lotions like Neosporin or Bacitracin
  • Seborrheic eczema (also called seborrheic dermatitis or seborrhea): is a very common form of mild skin inflammation of unknown cause that presents as yellowish, oily, scaly patches of skin on the scalp, face, ears, and occasionally other parts of the body. Often this is also called dandruff in adults or "cradle cap" in infants.
  • Nummular eczema: coin-shaped (round), isolated patches of irritated skin — most commonly on the arms, back, buttocks, and lower legs — that may be crusted, scaling, and extremely itchy
  • Neurodermatitis: a very particular type of dermatitis where the person frequently picks at their skin, causing rashes. The underling cause may be a sensitivity or irritation which sets off a cascade of repeated itching and scratching cycles. It may be seen as scratch marks and pick marks on the skin. Sometimes scaly patches of skin on the head, lower legs, wrists, or forearms caused by a localized itch (such as an insect bite) may become intensely irritated when scratched.
  • Stasis dermatitis: a skin irritation on the lower legs, generally related to circulatory problems and congestion of the leg veins. It may have a darker pigmentation, light-brown, or purplish-red discoloration from the congestion and back up of the blood in the leg veins. It's sometimes seen more in legs with varicose veins.


 Download the PDF from VitaminDWiki


See also web

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Typical Eczema sites on body, scratching - images from web

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Attached files

ID Name Comment Uploaded Size Downloads
10664 SCORAD Vit D.jpg admin 10 Oct, 2018 21:50 29.30 Kb 219
7437 Eczema sites.jpg admin 03 Dec, 2016 17:23 20.30 Kb 3359
7436 Eczema scratch.jpg admin 03 Dec, 2016 17:22 24.14 Kb 3483
3616 Eczema-Since-2nd-World-War4.jpg admin 14 Feb, 2014 03:58 89.33 Kb 11925
756 Vitamin D in Atopic Dermatitis, Asthma and Allergic Diseases - Aug 2010.pdf PDF of another paper admin 22 Sep, 2011 15:25 606.22 Kb 1784
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