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At birth, lower levels of vitamin D associated with higher levels of inflammation – Jan 2017

25-hydroxyvitamin D correlates with inflammatory markers in cord blood of healthy newborns.

Pediatr Res. 2017 Jan 13. doi: 10.1038/pr.2017.9. [Epub ahead of print]


Rosendahl J1, Holmlund-Suila E1, Helve O1, Viljakainen H1, Hauta-Alus H1, Valkama S1, Enlund-Cerullo M1, Hytinantti T1, Tervahartiala T2, Sorsa T2,3, Mäkitie O1,4,5, Andersson S1.
1Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
2Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
3Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
4Center for Molecular Medicine, Karolinska Institutet and Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
5Folkhälsan Research Center, Helsinki, Finland.

BACKGROUND:
Vitamin D is a potent immunomodulator and may play a role in the development of the fetal innate immune functions. The aim of our study was to evaluate inflammatory markers in cord blood of healthy newborns in relation to vitamin D status at birth.

METHODS:
We studied the concentrations of inflammatory markers, matrix metalloproteinase 8 (MMP-8) and high sensitivity CRP (hs-CRP), and 25-hydroxyvitamin D (25(OH)D) in cord blood of 939 healthy term infants born to mothers of Caucasian origin. We evaluated perinatal factors that affect the concentrations of MMP-8 and hs-CRP, and further explored associations between cord blood 25(OH)D and these inflammatory biomarkers.

RESULTS:
Majority (99%) of the cohort was vitamin D sufficient (>50 nmol/L or 20 ng/mL). We observed a positive correlation between cord blood 25(OH)D and MMP-8 concentrations, and between 25(OH)D and hs-CRP concentrations. After adjustment for potential confounders (parity, antenatal antibiotic treatment, gestational age, mode of delivery and maternal prepregnancy body mass index), the association of 25(OH)D with MMP-8 and hs-CRP remained significant.

CONCLUSION:
Cord blood 25(OH)D correlates with inflammatory markers MMP-8 and hs-CRP. The findings may reflect the diverse immunomodulatory functions of vitamin D in the innate immune response of the newborn.

PMID: 28085793 DOI: 10.1038/pr.2017.9
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