- Methylation of the Vitamin D Receptor Gene in Human Disorders
- VitaminDWiki – Cancer increases if poor Vitamin D Receptor
- VitaminDWiki - Vitamin D Receptor activation can be increased in many ways
- VitaminDWiki – The Vitamin D Receptor is associated with many health problems
- 55 health problems associated with poor VDR
- How to increase VDR activation
- VitaminDWiki – Vitamin D Receptor category:
- 55 health problems associated with poor VDR
- How to increase VDR activation
Methylation of the Vitamin D Receptor Gene in Human Disorders
Int. J. Mol. Sci. 2024, 25(1), 107; https://doi.org/10.3390/ijms25010107
by Beatrice Gasperini 1,†,Angela Falvino 1,†,Eleonora Piccirilli 2,Umberto Tarantino 2ORCID,Annalisa Botta 1,*ORCID and Virginia Veronica Visconti 1ORCID
1 Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, Italy
2 Department of Clinical Sciences and Translational Medicine, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, Italy
The Vitamin D Receptor (VDR) mediates the actions of 1,25-Dihydroxvitamin D3 (1,25(OH)2D3), which has important roles in bone homeostasis, growth/differentiation of cells, immune functions, and reduction of inflammation. Emerging evidences suggest that epigenetic modifications of the VDR gene, particularly DNA methylation, may contribute to the onset and progression of many human disorders. This review aims to summarize the available information on the role of VDR methylation signatures in different pathological contexts, including autoimmune diseases, infectious diseases, cancer, and others. The reversible nature of DNA methylation could enable the development of therapeutic strategies, offering new avenues for the management of these worldwide diseases.
 Download the PDF from VitaminDWiki
VDR associated Diseases searched for include:
- “VDR methylation in autoimmune diseases”,
- “VDR methylation AND Rheumatoid Arthritis”,
- “VDR methylation AND Multiple Sclerosis”,
- “VDR methylation AND Bechet’s disease”,
- “VDR methylation in infectious diseases”,
- “VDR methylation AND Tuberculosis disease”,
- “VDR methylation AND Hand Foot and Mouth disease”,
- “VDR methylation AND HIV”,
- “VDR methylation in cancer”,
- “VDR gene methylation AND breast cancer”,
- “VDR methylation AND Adrenocortical carcinoma”,
- “VDR methylation AND Hepatocellular carcinoma”,
- “VDR methylation AND Parathyroid adenomas”,
- “VDR methylation AND colorectal cancer”,
- “VDR methylation AND Osteoporosis”,
- “VDR methylation AND Male infertility”,
- “VDR methylation AND Recurrent Kidney stone formation”,
- “VDR methylation AND Type 2 Diabetes Mellitus”.
VitaminDWiki – Cancer increases if poor Vitamin D Receptor
Cancers get less Vitamin D when there is a poor Vitamin D Receptor
- Vitamin D Receptor pages in VitaminDWiki with CANCER in title 86 as of July 2023
- Cancer and the Vitamin D Receptor, a primer – Sept 2017
- Vitamin D Receptor (Cancers OR Viruses) - many studies
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Cancer (general) and VDR
23 articles - Breast Cancer and VDR
24 articles - Colon Cancer and VDR
13 articles - Prostate Cancer and VDR
7 articles - Skin Cancer and VDR
10 articles - Note some Health problems, such as some Cancers, protect themselves
by actively reducing Receptor activation subset of the above?
VitaminDWiki - Vitamin D Receptor activation can be increased in many ways
Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, Berberine, intense exercise, Butyrate Sulforaphane Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 16 known VDR activators
VitaminDWiki – The Vitamin D Receptor is associated with many health problems
530 studies in Vitamin D Receptor category Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
See also:
A poor VDR restricts Vitamin D from getting in the cells48 studies in the Resveratrol category It appears that 30% of the population have a poor VDR (40% of the Obese )
Health problems include: Autoimmune (
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems19 studies), Breast Cancer ( 24 studies), Colon Cancer ( 13 studies), Cardiovascular ( 23 studies), Cognition ( 16 studies), Diabetes ( 24 studies), Hypertension ( 9 studies), Infant ( 22 studies), Lupus ( 6 studies), Metabolic Syndrome ( 4 studies), Mortality ( 4 studies), Multiple Sclerosis ( 14 studies), Obesity ( 17 studies), Pregnancy ( 24 studies), Rheumatoid Arthritis ( 10 studies), TB ( 8 studies), VIRUS ( 37 studies), Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation
55 health problems associated with poor VDR
A poor VDR is associated with the risk of 55 health problems click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023 click here for details
Some health problem, such as Breast Cancer reduce the VDRVDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
How to increase VDR activation
Compensate for poor VDR by increasing one or more:Increasing Increases 1) Vitamin D supplement Sun
Ultraviolet -BVitamin D in the blood
and thus in the cells2) Magnesium Vitamin D in the blood
AND in the cells3) Omega-3 Vitamin D in the cells 4) Resveratrol Vitamin D Receptor 5) Intense exercise Vitamin D Receptor 6) Get prescription for VDR activator
paricalcitol, maxacalcitol?Vitamin D Receptor 7) Quercetin (flavonoid) Vitamin D Receptor 8) Zinc is in the VDR Vitamin D Receptor 9) Boron Vitamin D Receptor ?,
etc10) Essential oils e.g. ginger, curcumin Vitamin D Receptor 11) Progesterone Vitamin D Receptor 12) Infrequent high concentration Vitamin D
Increases the concentration gradientVitamin D Receptor 13) Sulfroaphane and perhaps sulfur Vitamin D Receptor 14) Butyrate especially gut Vitamin D Receptor 15) Berberine Vitamin D Receptor Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
VitaminDWiki – Vitamin D Receptor category:
530 studies in Vitamin D Receptor category Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
See also:
A poor VDR restricts Vitamin D from getting in the cells48 studies in the Resveratrol category It appears that 30% of the population have a poor VDR (40% of the Obese )
Health problems include: Autoimmune (
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems19 studies), Breast Cancer ( 24 studies), Colon Cancer ( 13 studies), Cardiovascular ( 23 studies), Cognition ( 16 studies), Diabetes ( 24 studies), Hypertension ( 9 studies), Infant ( 22 studies), Lupus ( 6 studies), Metabolic Syndrome ( 4 studies), Mortality ( 4 studies), Multiple Sclerosis ( 14 studies), Obesity ( 17 studies), Pregnancy ( 24 studies), Rheumatoid Arthritis ( 10 studies), TB ( 8 studies), VIRUS ( 37 studies), Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation
55 health problems associated with poor VDR
A poor VDR is associated with the risk of 55 health problems click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023 click here for details
Some health problem, such as Breast Cancer reduce the VDRVDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
How to increase VDR activation
Compensate for poor VDR by increasing one or more:Increasing Increases 1) Vitamin D supplement Sun
Ultraviolet -BVitamin D in the blood
and thus in the cells2) Magnesium Vitamin D in the blood
AND in the cells3) Omega-3 Vitamin D in the cells 4) Resveratrol Vitamin D Receptor 5) Intense exercise Vitamin D Receptor 6) Get prescription for VDR activator
paricalcitol, maxacalcitol?Vitamin D Receptor 7) Quercetin (flavonoid) Vitamin D Receptor 8) Zinc is in the VDR Vitamin D Receptor 9) Boron Vitamin D Receptor ?,
etc10) Essential oils e.g. ginger, curcumin Vitamin D Receptor 11) Progesterone Vitamin D Receptor 12) Infrequent high concentration Vitamin D
Increases the concentration gradientVitamin D Receptor 13) Sulfroaphane and perhaps sulfur Vitamin D Receptor 14) Butyrate especially gut Vitamin D Receptor 15) Berberine Vitamin D Receptor Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
An activated Vitamin D Receptor fights Autoimmune Diseases, Infections, Cancers, etc. – Dec 20233046 visitors, last modified 13 Jan, 2024, This page is in the following categories (# of items in each category) - Breast Cancer and VDR