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Alopecia areata (spot baldness) associated with 8.5 ng lower levels of vitamin D – meta-analysis April 2018

Increased prevalence of vitamin D deficiency in patients with alopecia areata: A systematic review and meta‐analysis

Journal of the European Academy Dermology and Venereology 6 April 2018, https://doi.org/10.1111/jdv.14987
S Lee B J Kim C H Lee W S Lee

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  • Alopecia areata Wikipedia
    “Alopecia areata, also known as spot baldness, is a condition in which hair is lost from some or all areas of the body. Often it results in a few bald spots on the scalp, each about the size of a coin”
    “Alopecia areata is believed to be an autoimmune disease. Risk factors include a family history of the condition. Among identical twins if one is affected the other has about a 50% chance of also being affected”
    “There is no cure for the condition.”
    “The condition affects 0.1%–0.2% of the population”

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Background
Alopecia areata (AA) is a hair follicle‐specific autoimmune disorder. Vitamin D deficiency has been associated with various autoimmune disorders for its immunomodulatory effects. However, in previous studies, there had been inconsistent association found between AA and vitamin D deficiency.

Objective: To demonstrate the differences of the mean serum 25‐hydroxyvitamin D level and prevalence of vitamin D deficiency between AA subjects and non‐AA controls.

Methods: A systematic review and meta‐analysis of observational studies on AA and serum vitamin D levels and/or prevalence of vitamin D deficiency was performed searching MEDLINE, Cochrane, Web of Science, and Google Scholar databases.

Results
In all, 14 studies including a total of 1,255 AA subjects and 784 non‐AA control were analyzed. The mean serum 25‐hydroxyvitamin D level was significantly lower in AA subjects (‐8.52 ng/dL; 95% confidential interval; ‐5.50 to ‐11.53). The subjects with AA had higher odds of vitamin D deficiency of vitamin D deficiency (odds of 3.55; 2.03 to 6.20, mean prevalence of 75.5%; 60.8 to 86.0%). However, it was difficult to find clear correlation between serum 25‐hydroxyvtamin D level and extent of hair loss in AA.

Conclusion
The AA subjects had lower serum 25‐hydroxyvitamin D level and vitamin D deficiency was highly prevalent compared to non‐AA controls. Hence, Vitamin D deficiency should be assessed in AA patients. Furthermore, nutritional supplementation of vitamin D or topical vitamin D analogues can be considered for AA patients with vitamin D deficiency. The limitation of this study is the highly heterogeneity of the included studies.

Created by admin. Last Modification: Tuesday December 24, 2019 16:36:23 GMT-0000 by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
9727 AA4.jpg admin 17 Apr, 2018 20:34 9.60 Kb 2019
9726 AA3.jpg admin 17 Apr, 2018 20:34 6.08 Kb 12632
9725 AA2.jpg admin 17 Apr, 2018 20:34 8.93 Kb 3103
9724 AA Wikipedia.jpg admin 17 Apr, 2018 20:33 16.36 Kb 2955
9723 AA figure B.jpg admin 17 Apr, 2018 20:33 56.56 Kb 2735
9722 Alopecia areata.pdf PDF 2018 admin 17 Apr, 2018 20:32 803.30 Kb 241
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