Are Serum 25-Hydroxyvitamin D Deficiency and Insufficiency Risk Factors for the Incidence of Dynapenia?
Calcif Tissue Int. 2022 Sep 15.doi: 10.1007/s00223-022-01021-8
Maicon Luís Bicigo Delinocente 1 , Mariane Marques Luiz 2 , Dayane Capra de Oliveira 2 , Aline Fernanda de Souza 2 , Paula Camila Ramírez 2 3 , Roberta de Oliveira Máximo 2 , Natália Cochar Soares 4 , Andrew Steptoe 5 , Cesar de Oliveira 5 , Tiago da Silva Alexandre 6 7 8 9
Epidemiological evidence showing the association between low 25(OH)D and age-related reduction in neuromuscular strength (dynapenia) is a paucity and controversial and, to date, the effect of osteoporosis and vitamin D supplementation on these associations has not been measured. Thus, we analyze whether serum 25(OH)D deficiency and insufficiency are risk factors for the incidence of dynapenia in individuals aged 50 or older and whether osteoporosis or vitamin D supplementation modify these associations. For that, 3205 participants of the ELSA study who were non-dynapenic at baseline were followed for 4 years. Vitamin D was measured at baseline by the serum concentration of 25(OH)D and classified as sufficient (> 50 nmol/L), insufficient (≥ 30 and ≤ 50 nmol/L) or deficient (< 30 nmol/L). The incidence of dynapenia was determined by a grip strength < 26 kg for men and < 16 kg for women at the end of the 4-year follow-up. Poisson regression models were adjusted by sociodemographic, behavioral, clinical and biochemical characteristics. Serum 25(OH)D deficient was a risk factor for the incidence of dynapenia (IRR = 1.70; 95% CI 1.04-2.79). When only individuals without osteoporosis and those who did not use vitamin D supplementation were analyzed, both serum 25(OH)D deficiency (IRR = 1.78; 95% CI 1.01-3.13) and insufficiency (IRR = 1.77; 95% CI 1.06-2.94) were risk factors for the incidence of dynapenia.
In conclusion, a serum level of 25(OH)D < 30 nmol/L is a risk factor for the incidence of dynapenia. Among individuals without osteoporosis and those who do not take vitamin D supplementation, the threshold of risk is higher (≤ 50 nmol/L).
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43+ Senior pages with STRENGTH or MUSCLE or GRIP or SARCOPENIA in title
Sarcopenia = age-related loss of muscle mass
This list is automatically updated
Items found: 45
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Pelvic Organ Prolapse after menopause 5.6 X more likely if low Vitamin D (weak muscles) – Oct 2023 |
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02 Oct, 2023 |
Vitamin D Receptors in muscles decrease with age in those with Osteoporosis - 2018 |
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20 Aug, 2023 |
Sarcopenia (muscle loss) fought by Vitamin D, exercise and protein - many studies |
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11 Jul, 2023 |
More muscle strength 80 years after being born in warm season (no surprise) – Nov 2022 |
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26 Nov, 2022 |
Age-related loss of strength (Dynapenia) 1.7X more likely if low Vitamin D – Sept 2022 |
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16 Sep, 2022 |
Frailty and low muscle mass both associated with low vitamin D – Aug 2013 |
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14 Sep, 2022 |
Omega-3 improves elderly muscles – 2 meta-analyses |
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06 Jun, 2022 |
Loss of muscle strength –sarcopenia – one of the suspects is vitamin D – Aug 2012 |
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16 Oct, 2021 |
Low muscle strength predicts low vitamin D level in elderly – March 2021 |
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06 May, 2021 |
Adding just a little vitamin D does not help (muscle mass in this case) – meta-analysis Jan 2021 |
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06 Feb, 2021 |
Sarcopenia (muscle loss) is 1.6X more likely if poor Vitamin D receptor – July 2020 |
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23 Jul, 2020 |
Sarcopenia reduction: Protein, Leucine, Omega-3, Vitamin D, and exercise - hypothesis Aug 2018 |
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30 Jan, 2020 |
Less muscle loss associated with eating more fish (Omega-3, Vitamin D, Magnesium, etc) – Jan 2020 |
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30 Jan, 2020 |
Muscles of senior women not helped by just vitamin D (also need exercise) – Aug 2019 |
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10 Aug, 2019 |
Muscle loss (sarcopenia) may be both prevented and treated by Omega-3 – Feb 2019 |
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23 Feb, 2019 |
Exercise plus vitamin D increases elderly muscles (Nordic walking in this case) – RCT Sept 2018 |
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14 Sep, 2018 |
Postmenopausal women need Vitamin D, protein and exercise to prevent loss of muscle and bone – Aug 2018 |
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21 Aug, 2018 |
Dietary Protein, Muscle and Physical Function in the Very Old – July 2018 |
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17 Aug, 2018 |
Disability was 1.9 X more likely if weak muscles and low vitamin D two years before – Aug 2018 |
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06 Aug, 2018 |
Muscle problems are both treated and avoided by Vitamin D – April 2018 |
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03 Jul, 2018 |
Sarcopenia does not officially exist in Australia, but 1 in 3 of their seniors have it - July 2018 |
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03 Jul, 2018 |
Seniors gained 0.3 kg of muscle in 6 weeks with 800 IU and Leucine protein – Aug 2017 |
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29 Aug, 2017 |
Fast twitch muscles increased by Vitamin D in athletes and seniors (reduce falling) – Oct 2016 |
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08 Jun, 2017 |
Sarcopenia: Nutrition and physical activity – systematic review – Jan 2017 |
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10 Mar, 2017 |
Muscle strength of senior women increased 25 percent with vitamin D, decreased 6 percent with placebo – Oct 2016 |
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08 Mar, 2017 |
More fast twitch muscles (IIA) are associated with higher levels of Vitamin D – Feb 2017 |
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02 Mar, 2017 |
Added 1 lb of muscle to sarcopenia adults in 13 weeks with just 800 IU vitamin D and protein – RCT Jan 2017 |
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31 Jan, 2017 |
Improved muscle function in postmenopausal women with just 1,000 IU of vitamin D daily – RCT May 2015 |
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31 Oct, 2016 |
Senior muscles increased somewhat with Omega-3 – RCT July 2015 |
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18 Jan, 2016 |
Sarcopenia and non-alcoholic fatty liver disease (vitamin D not mentioned) – Sept 2013 |
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07 Mar, 2015 |
Hypothesis: Sarcopenia and other senior problems are related to low gastric acid |
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01 Feb, 2015 |
Elderly lost extra half pound of leg and arm muscle mass if low vitamin D (6 years) – Oct 2014 |
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27 Jan, 2015 |
Muscle increased 17 percent in vitamin D insufficient elderly getting 4,000 IU for 4 months – RCT Oct 2013 |
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27 Jan, 2015 |
Low Vitamin D breaks down muscle by interferring with protein - Editorial Nov 2013 |
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27 Jan, 2015 |
Vitamin D supplementation help muscles of seniors who are vitamin D deficient – meta-analysis July 2014 |
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18 Jul, 2014 |
MRI of elderly skeletal muscle lacking vitamin D – April 2014 |
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30 Apr, 2014 |
Muscle cells differentiate into fat cells if there is low vitamin D in petrie dish – April 2013 |
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30 Apr, 2014 |
Elderly lower limb muscle strength improved with Vitamin D supplementation - Meta-analysis Oct 2013 |
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23 Dec, 2013 |
Vitamin D improves muscle strength if deficient – meta-analysis - Oct 2010 |
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19 Dec, 2013 |
Type 2 muscles, not all muscles, get benefit from Vitamin D - Dec 2012 |
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23 Oct, 2013 |
Vitamin K-2 (180 ug MK-7) helped both bone density and strength – RCT March 2013 |
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18 Apr, 2013 |
No correlation found between vitamin D and sarcopenia – German dissertation Jan 2013 |
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22 Jan, 2013 |
Vitamin D2 intervention increased elderly muscle strength – Nov 2010 |
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10 Nov, 2012 |
Meta-analysis of RCT – vitamin D might increase senior muscle function – Sept 2010 |
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14 Sep, 2010 |
Novel treatment approaches to cachexia and sarcopenia: |
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13 Apr, 2010 |