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Active Lupus associated with 3.8 X less activated Vitamin D Receptor – May 2019

Vitamin D receptor expression in peripheral blood mononuclear cells is inversely associated with disease activity and inflammation in lupus patients.

Clin Rheumatol. 2019 May 18. doi: 10.1007/s10067-019-04594-2.
Sun J1, Liu C2, Zhang S1, Yi B1, Gui M1, Zhang W1, Li YC3, Zhang H4.

VitaminDWiki

This is just an association, but what is the cause?

  1. Low VDR ==> less vitamin D in tissue ==>Active Lupus
  2. Active Lupus reduces VDR Activation
    • Note - several diseases, such as some cancers, are known to actively reduce the VDR
  3. Some unknown third item affects both

Items in both categories Lupus and Vitamin D Receptor are listed here:

  • Lupus category listing has 61 items along with related searches

 Download the PDF from Sci-Hub via VitaminDWiki
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OBJECTIVE: Systemic lupus erythematosus (SLE) is characterized by uncontrolled production of pro-inflammatory cytokines. Vitamin D receptor (VDR) has potent anti-inflammatory activities. The aim of this study was to examine the correlation between VDR expression and inflammation and disease activity in patients with SLE.

METHODS:
Ninety-five SLE patients were recruited and divided into two groups, active and inactive, according to their SLE disease activity index (SLEDAI)-2 K, and 40 healthy individuals served as controls. The expression of VDR and NF-κB p65 in peripheral blood mononuclear cells (PBMCs) was determined by quantitative RT-PCR and Western blotting. VDR expression was correlated with inflammatory and diseases parameters in SLE patients. VDR regulation was also studied in THP-1 and Jurkat cell lines.

RESULTS:
PBMC VDR expression was downregulated in SLE patients, especially in the active SLE group. VDR mRNA levels were negatively correlated with SLEDAI-2 K (r = - 0.348, P = 0.001), Systemic Lupus International Collaborating Clinics (SLICC) renal activity scores (r = - 0.346, P = 0.014), and proteinuria (r = - 0.309, P = 0.002) and positively associated with serum complement C3 levels (r = 0.316, P = 0.002). Multiple stepwise regression analysis indicated that PBMC VDR downregulation was an independent risk factor for SLEDAI-2 K. VDR levels were also negatively correlated with NF-κB p65 (r = - 0.339, P = 0.001), TNF-α (r = - 0.268, P = 0.009), and IL-6 (r = - 0.313, P = 0.002) levels. In monocyte and T lymphocyte cell lines, TNF-α suppressed VDR expression, whereas 1,25-dihydroxyvitamin D blocked TNF-α-induced VDR downregulation.

CONCLUSION: PBMC VDR expression is inversely associated with disease activity and inflammation in SLE patients, and VDR downregulation is likely driven by inflammation.


Created by admin. Last Modification: Saturday October 5, 2019 12:03:50 GMT-0000 by admin. (Version 4)

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11995 VDR Lupus.jpg admin 20 May, 2019 11:19 18.68 Kb 330
11994 VDR Lupus 2019.pdf PDF 2019 admin 20 May, 2019 11:19 1.42 Mb 241
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