Comprehensive Clinic, Laboratory and Instrumental Evaluation of Children with COVID-19: A 6-Months Prospective Study
J Med Virol. 2021 Feb 11. doi: 10.1002/jmv.26871.
Sara Isoldi 1 2, Saverio Mallardo 1, Alessia Marcellino 1, Silvia Bloise 1, Anna Dilillo 1, Donatella Iorfida 1, Alessia Testa 1, Emanuela Del Giudice 1, Vanessa Martucci 1, Mariateresa Sanseviero 1, Antonio Barberi 1, Massimo Raponi 1, Flavia Ventriglia 1, Riccardo Lubrano 1
Objectives: To perform a comprehensive clinic, laboratory and instrumental evaluation of children affected by COVID-19.
Methods: Children with a positive result of nasopharyngeal swab for SARS-CoV-2 underwent laboratory tests, anal and conjunctival swab, electrocardiography, lung, abdomen and cardiac ultrasound. 24-h ambulatory blood pressure monitoring was performed if abnormal basal blood pressure. Patients were followed-up for 6 months.
Results: 316 children were evaluated; 15 were finally included. Confirmed family member SARS-CoV-2 infection was present in all. 27% were asymptomatic. Anal and conjunctival swabs tests resulted negative in all. Patients with lower BMI presented significantly higher viral loads.
Main laboratory abnormalities were:
- LDH increasing (73%),
- low vitamin D levels (87%)
- hematuria (33%),
- proteinuria (26%),
- renal hyperfiltration (33%) and
- hypofiltration (13%).
Two of the patients with hyperfiltration exhibited high blood pressure levels at diagnosis, and persistence of a prehypertension at 6-month follow-up. No abnormalities were seen at ultrasound, excepting for one patient who exhibited B-lines at lung sonography. IgG seroconversion was observed in all at 1-month.
Conclusions: Our study confirm that intra-family transmission is important. The significant higher viral loads recorded among patients with lower BMI, together with low vitamin D levels, support the impact of nutritional status on immune system. Renal involvement is frequent even among children with mild COVID-19, therefore prompt evaluation and identification of patients with reduced renal function reserve would allow a better stratification and management of patients. Seroconversion occurs also in asymptomatic children, with no differences in antibodies titer according to age, sex and clinical manifestations.
Virus and infant-child studies are listed here:
- US has the most vaccinations before age 1 and the most deaths - March 2024
- 18,000 schoolchildren in Canada to be suspended for not being vaccinated - Feb 2024
- COVID Vaccinated Children 1.25 X More Likely to Be Hospitalized for Respiratory Illness - CDC Jan 2024
- France has injected 200,000 infants with RSV vaccine, based on no long-term data - Here we go again - Dec 2023
- Brazil mandates COVID-19 vaccine for children - Nov 2023
- Doctors in NY cannot opt out of COVID boosters for children - Oct 2023
- Infants getting lots of vaccinations are 2X more likely to die - July 2023
- COVID, Long-COVID and Vitamin D in children - Review April 2023
- Multisystem Inflammatory Syndrome of COVID in Children 3X more likely if low Vitamin D – Feb 2023
- PICU layoffs due to pandemic lulls, but children are now getting 3 years of viral infection all at once – Oct 2022
- COVID 5.5 X more likely to be severe if low Vitamin D (children in this case) – Oct 2022
- Tripledemic: Flu, COVID, and RSV (all fought by Vitamin D) - Oct 2022
- CDC advised to recommended annual COVID vaccination of all children over 6 months old – Oct 20, 2022
- 6X increase in excess deaths of children since vaccinations were started - Oct 2022
- Early puberty during pandemic (low vitamin D) - several studies
- COVID kids were more likely to have a poor VDR (4.3 X), than low Vitamin D (2.6 X) – Sept 2022
- Recent increases in pediatric endocrine problems may be decreased by Vitamin D – Aug 2022
- COVID children helped by Vitamin D, trial terminated: unethical to not give Vitamin D to all: – RCT July 2022
- Increase in children with low vitamin D and with tibia fractures during COVID – June 2022
- 28,859 deaths and 238,412 serious injuries due to vaccines, how many more when add ages 0.5 - 5 – June 2022
- Pandemic Vitamin D levels dropped by 3.3 ng (perhaps less D, more health problems) – May 2022
- Problems after childhood vaccinations - many studies
- FDA approved 5-11 vaccine booster (based tiny unpublished study without asking advisory panel) May 2022
- Remdesivir approved to treat COVID in Infants, yet Vitamin D is 3000 X more cost effective and widely used - April 2022
- Risk factors for severe COVID in children are all related to low vitamin D (same as adults) - April 2022
- Hepatitis normally rare in children: huge increase after lockdown (Adenovirus, low Vitamin D) - April 2022
- Children with higher Vitamin D had less severe COVID (no surprise) – April 2022
- Children have less severe COVID, but just as much long-haul as adults - April 2022
- Croup (due to viruses) has surged with Omicron - March 2022
- COVID children with multisystem inflammatory syndrome have less than 10 ng of vitamin D – March 2022
- 16,000 Physicians and Scientists Agree Kids Shouldn’t Get COVID Vaccine - Dec 15, 2021
- Younger are much less likely to die of COVID than elderly (posters) - Nov 2021
- COVID Vaccination trial for kids: 11 red flags - Oct 25, 2021
- Children and COVID - many studies
- 8 of 10 pediatric COVID-19 infections were Vitamin D deficient (49 patients) – May 2021
- Severe pediatric COVID 5.5 more likely if low vitamin D (review of 6 studies) -July 2021
- Sudden Infant Deaths (SIDS) soon after vaccination - several studies
- Hospitalized children with COVID-19 and inflammation had lower vitamin D – March 2021
- Severe childhood COVID-19 associated with Vitamin D deficiency (hospital in Turkey) – March 2021
- Vitamin D might reduce Multisystem Inflammatory Syndrome in children – March 2021
- 87 percent of children with COVID–19 had low vitamin D (small study) – Feb 2021
- Vaccinations resulted in increased office visits for children 16 months later - Nov 2020
- 13 possible reasons why COVID-19 is less severe in children – Dec 1, 2020
- Vitamin D associated with reduced COVID-19 risks in children - Grassroots Nov 2020
- Children with low vitamin D far more likely to hospitalized with COVID-19 – Oct 2020
- Respiratory viral infection (RSV) and low vitamin D - many studies
- Increased weight in children 8X more likely for each unit increase in adenovirus (if ignore Vitamin D) – Nov 2019
- Severe hand, foot, and mouth virus is 2.9 X more likely if poor Vitamin D receptor – Oct 2018
- More US infants die in 1st day than in all other developed countries COMBINED (and US gives vaccine in first day) – May 2013
- Vaccinated children had more chronic diseases - Sept 2018