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5X more likely to test positive for COVID-19 if low vitamin D in previous 5 years (900,000 people) - Dec 4, 2020

Increased Risk for Covid-19 in patients with Vitamin D deficiency.

Nutrition, https://doi.org/10.1016/j.nut.2020.111106
JosephKatzDMD1SijiaYueMSc2WeiXuePhD2

VitaminDWiki

Data from people in Florida over a 5 year time period
Some had a vitamin D deficiency billable code of E 55.9 (generally < 20 ng)
"From a total population of 987,849 patients,

  • 887 were diagnosed with positive Covid-19,
  • 31,950 had a diagnosis of Vitamin D deficiency and
  • 87 patients had both vitamin D deficiency and Covid-19. "

In VitaminDWiki

COVID-19 treated by Vitamin D - studies, reports, videos
As of Aug 1, the page had:  34 trials6 trial results,   21 meta-analyses and reviews,   62 observations,   34 recommendations,   55 associations,  89 speculations,  45 videos   see related:   Governments,   HealthProblems,   Hospitals,  Dark Skins,   26 risk factors are ALL associated with low Vit D,   Recent Virus pages   Fight COVID-19 with 50K Vit D weekly   Vaccine problems

One of the 34 Observational Trials


Clinical trials are proving that Vitamin D fights COVID-19 in hospitals includes
3 very successful Clinical Trials have been published so far (31 trials underway)

  1. COVID-19 defeated by calcifediol form of Vitamin D in Spain - pilot RCT Aug 29, 2020
    • Trial used a faster-acting form of vitamin D which is only available by prescription
  2. COVID-19 defeated 3x faster by 420,000 IU Vitamin D nanoemulsion – RCT Nov 12, 2020 - supplier not stated
  3. 2X fewer COVID-19 deaths observed with 300,000 IU of vitamin D

Note: VitaminDWiki guesses that if the data could be re-analyzed for those >40 ng/ml of vitamin D, that the Risk of COVID-19 would be about 20X
We offered to do that re-analysis, but the author will not release the data without IRB approval
 - which appears to take about 20 hours of time over 4-8 weeks

 Download the final PDF from VitaminDWiki
 Download the preprint PDF from VitaminDWiki
Image

Background
: The new Covid-19 pandemic has disproportionally affected a variety of patients with underlying risk factors such as respiratory and cardiovascular diseases, diabetes, obesity, and African American race. Vitamin D deficiency that can result in compromised immune response has also been linked with increased risk and increased morbidities associated with Covid-19. In the absence of large scale longitudinal studies that can determine the strength of association between vitamin deficiency and Covid-19, cross sectional studies of large cohorts of patients can be used.

Material and methods
: We have used the i2b2 patient's registry platform at the University of Florida Health center to generate a count of patients using the ICD 10 diagnoses codes for the period of 10/1/2015 – 6/30/2020. Logistic regression of the aggregates was used for the analysis.

Results
: Patients with vitamin D deficiency were 4.6 times more likely to be Covid-19 positive, as indicated by a COV19 ICD 10 diagnostic code, than patients with no deficiency (P-value<0.001). The association decreased slightly after adjusting for gender (with OR=4.58, p<0.001) and for malabsorption (with OR=4.46, p<0.001) respectively. The association decreased significantly but remained robust with P-value<0.001 after adjusting for race (with OR=3.76, p<0.001), periodontal disease status (with OR=3.64, p<0.001), diabetes (with OR=3.28, p<0.001) and obesity (with OR=2.27, p<0.001), respectively. In addition, patients with vitamin D deficiency were 5 times more likely to be infected with Covid-19 than patients with no deficiency after adjusting for age groups (OR=5.155, p<0.001).

Conclusion
Vitamin D deficiency is significantly associated with increased risk for Covid-19.


Created by admin. Last Modification: Thursday April 22, 2021 15:19:44 GMT-0000 by admin. (Version 17)

Attached files

ID Name Comment Uploaded Size Downloads
15485 Increased risk for COVID-19 in patients with vitamin D deficiency.pdf PDF 2021 admin 22 Apr, 2021 15:14 549.86 Kb 29
15484 Bar Chart.jpg admin 22 Apr, 2021 15:13 53.44 Kb 121
14686 Increased risk for Covid-19 in patients with Vitamin D deficiency Dec 4.pdf admin 08 Dec, 2020 22:49 807.91 Kb 110
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