Data from people in Florida over a 5 year time period
Some had a vitamin D deficiency billable code of E 55.9 (generally < 20 ng)
"From a total population of 987,849 patients,
- 887 were diagnosed with positive Covid-19,
- 31,950 had a diagnosis of Vitamin D deficiency and
- 87 patients had both vitamin D deficiency and Covid-19. "
COVID-19 treated by Vitamin D - studies, reports, videos
As of Jan 26 had: 34 trials, 4 trial results, 13 meta-analyses and reviews, 46 observations, 27 recommendations, 42 associations, 84 speculations, 38 videos see also COVID-19 and Vitamin D: Governments. Health problems. Hospitals
One of the 34 Observational Trials
- Rate of COVID-19 test positive is 40 pcnt lower if high vitamin D (192,000 people) - Holick Sept 2020
Clinical trials are proving that Vitamin D fights COVID-19 in hospitals includes
3 very successful Clinical Trials have been published so far (31 trials underway)
- COVID-19 defeated by calcifediol form of Vitamin D in Spain - pilot RCT Aug 29, 2020
- Trial used a faster-acting form of vitamin D which is only available by prescription
- COVID-19 defeated 3x faster by 420,000 IU Vitamin D nanoemulsion – RCT Nov 12, 2020 - supplier not stated
- Nanoemulsion forms of Vitamin D might be faster acting than Calcifediol (above) if swished in the mouth (gets directly to the blood, is not delayed by gut)
- 20+ Vitamin D emulsion suppliers on Amazon Nutrasal Micro D3 1 teaspoon = 200,000 IU
- but not (yet) available thru pharmacies nor medical suppliers
- 2X fewer COVID-19 deaths observed with 300,000 IU of vitamin D
Note: VitaminDWiki guesses that if the data could be re-analyzed for those >40 ng/ml of vitamin D, that the Risk of COVID-19 would be about 20X
We offered to do that re-analysis, but the author will not release the data without IRB approval
- which appears to take about 20 hours of time over 4-8 weeks
: The new Covid-19 pandemic has disproportionally affected a variety of patients with underlying risk factors such as respiratory and cardiovascular diseases, diabetes, obesity, and African American race. Vitamin D deficiency that can result in compromised immune response has also been linked with increased risk and increased morbidities associated with Covid-19. In the absence of large scale longitudinal studies that can determine the strength of association between vitamin deficiency and Covid-19, cross sectional studies of large cohorts of patients can be used.
Material and methods
: We have used the i2b2 patient's registry platform at the University of Florida Health center to generate a count of patients using the ICD 10 diagnoses codes for the period of 10/1/2015 – 6/30/2020. Logistic regression of the aggregates was used for the analysis.
: Patients with vitamin D deficiency were 4.6 times more likely to be Covid-19 positive, as indicated by a COV19 ICD 10 diagnostic code, than patients with no deficiency (P-value<0.001). The association decreased slightly after adjusting for gender (with OR=4.58, p<0.001) and for malabsorption (with OR=4.46, p<0.001) respectively. The association decreased significantly but remained robust with P-value<0.001 after adjusting for race (with OR=3.76, p<0.001), periodontal disease status (with OR=3.64, p<0.001), diabetes (with OR=3.28, p<0.001) and obesity (with OR=2.27, p<0.001), respectively. In addition, patients with vitamin D deficiency were 5 times more likely to be infected with Covid-19 than patients with no deficiency after adjusting for age groups (OR=5.155, p<0.001).
Vitamin D deficiency is significantly associated with increased risk for Covid-19.