- Association of Maternal Gestational Vitamin D Supplementation with Respiratory Health of Young Children
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36 studies in both categories Pregnancy and Breathing - VitaminDWiki -
6 studies in both categories Pregnancy and Loading Dose - Dosing at the 7th month (week 28) provides no benefit in weeks 0-28
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Association of Maternal Gestational Vitamin D Supplementation with Respiratory Health of Young Children
Nutrients Volume 15 Issue 10 10.3390/nu15102380
by Fanny Loddo 1,Steve Nauleau 2,David Lapalus 2,Sophie Tardieu 3,Olivier Bernard 2 andFarid Boubred 1,4,*- 1 APHM, Neonatal Unit, Hospital University la Conception, 13005 Marseille, France
- 2 Regional Health Agency, Provence-Alpes-Côte d’Azur, 13005 Marseille, France
- 3 APHM, Public Health and Medical Information Department, EA 3279, CEReSS–Health Service Research and Quality of Life Centre, 13005 Marseille, France
- 4 Aix-Marseille Université, C2VN, INRAe, INSERM, 13005 Marseille, France
Additional benefits: 15% less RD if > 40 weeks, etc,
This study aimed to evaluate the association between maternal gestational Vitamin D3 supplementation and early respiratory health in offspring. This was a population-based record-linkage study which used data from the French National Health Database System.
Maternal Vitamin D3 supplementation consisted of a single high oral dose of cholecalciferol, (100,000 IU) from the seventh month of pregnancy, according to national (French) guidelines. In total, 125,756 term-born singleton children were included, of which 37% had respiratory illness defined as hospital admission due to respiratory causes or inhalation treatment up to 24 months of age.
Infants prenatally exposed to maternal Vitamin D3 supplementation (n = 54,596) were more likely to have a longer gestational age (GA) at birth (GA 36–38 weeks, 22% vs. 20%, p < 0.001 in exposed vs. non-exposed infants, respectively).
After adjusting for the main risk factors (maternal age, socioeconomic level, mode of delivery, obstetrical and neonatal pathology, birth weight appropriateness, sex, and birth season), the risk of RD was found to be 3% lower than their counterparts (aOR [IC 95%], 0.97 [0.95–0.99], p = 0.01). In conclusion, this study provides evidence for the association between maternal gestational Vitamin D3 supplementation and improved early respiratory outcomes in young children.
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36 studies in both categories Pregnancy and Breathing This list is automatically updated
- Microplastics suspected to cause Digestive, Reproductive, and Respiratory problems (mice and women) - Dec 2024
- 40 cents of Vitamin D given once during pregnancy reduced respiratory problems by 3% – May 2023
- 3% fewer respiratory problems in children if single 100K vitamin D in 3rd trimester – May 2023
- Resulting childhood Asthma cut in half if 4,400 IU Vitamin D daily while pregnant - RCT April 2023
- Children had poor lung function if mothers had low vitamin D while pregnant – Nov 2022
- Small vitamin D doses given during pregnancy do not reduce childhood asthma – meta-analysis Dec 2020
- Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019
- Childhood Asthma somewhat reduced by 2400 IU vitamin D late in pregnancy (néed more, earlier) March 2019
- Childhood Asthma risk greatly reduced if mothers were given 4,400 IU Vitamin D daily – RCT 2019
- Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018
- Asthma 7 percent less likely for every 40 IU increase in (early) maternal diet – Feb 2018
- Pregnant women with low vitamin D (e.g. asthmatics) were more likely to have infants with vitamin D problems (asthmatics) – Jan 2018
- Lots of sugar while pregnant doubles asthma risk – 2017
- Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT Oct 2017
- Reduction of infant asthma may require good vitamin D when lung development starts (4 weeks) – March 2017
- Birth asphyxia 2.4 times more likely if mother was vitamin D deficient – 2016
- Asthma reduced 31 percent when Omega-3 taken during pregnancy – RCT Dec 2016
- Vitamin D during pregnancy reduces risk of childhood asthma by 13 percent – meta-analysis Dec 2016
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- Asthmatic pregnant women had 30 percent more preterm births if air pollution (vitamin D not mentioned) – March 2016
- Asthma in 3 year olds decreased somewhat with 4,000 IU during pregnancy – RCT Jan 2016
- Asthma trial underway - 4,000 IU during pregnancy - March 2014
- Infant wheezing 40 percent less likely if mother supplemented with vitamin D, vitamin E, or Zinc – meta-analysis Aug 2015
- Respiratory distress after preterm birth is more likely if low vitamin D – review April 2015
- Wheezing reduced 35 percent if vitamin D added during pregnancy – April 2015
- Newborn acute lower respiratory tract infection associated with low maternal vitamin D – March 2015
- Low vitamin D during pregnancy associated with four health problems in children – Jan 2015
- Just 700 IU of vitamin D during pregnancy reduced rate of asthma at age 7 by 26 percent – Oct 2013
- Single dose of 200,000 IU of vitamin D during pregnancy did not reduce wheezing 3 years later – June 2013
- Season of birth associated with Pneumonia (10 %) and Multiple Sclerosis (30 %) – May 2013
- Dial D for danger – absurd editorial in Thorax – Oct 2012
- High maternal vitamin D resulted in 30 percent less infant problems with breathing – Nov 2011
- Smoking while pregnant lowers vitamin D and increases child asthma by 3.6 X – Aug 2011
- 800 IU Vitamin D while pregnant decrease child asthma by 2X- Sept 2010
- Vitamin D Newsletter May 2010
- Winter babies are more prone to food allergies
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6 studies in both categories Pregnancy and Loading Dose This list is automatically updated
- 40 cents of Vitamin D given once during pregnancy reduced respiratory problems by 3% – May 2023
- Breastfeeding Vitamin D loading dose of 300,000 IU is OK - UK govt. Dec 2023
- Vitamin D during pregnancy – single 200,000 IU similar to daily 5,000 IU – April 2020
- Call to action – more Vitamin D for pregnancies, loading doses are OK – Holick Aug 2019
- Pregnancies helped a lot by Vitamin D (injection then 50,000 IU monthly) – RCT May 2018
- 300,000 IU injection loading dose of vitamin D3 stopped gestational diabetes in RCT – Oct 2011
Dosing at the 7th month (week 28) provides no benefit in weeks 0-28
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30 ; Depression 21 ; Diabetes 44 ; Obesity 18 ; Hypertension 44 ; Breathing 36 ; Omega-3 45 ; Vitamin D Receptor 24 Click here for details - All items in category Infant/Child
856 items - Pregnancy needs at least 40 ng of vitamin D, achieved by at least 4,000 IU – Hollis Aug 2017
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- Call to action – more Vitamin D for pregnancies, loading doses are OK – Holick Aug 2019
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- Fertility problem (PCOS) reduced by vitamin D, etc: many studies 15+
- 94+ Gestational Diabetes
- Caesarean birth much more likely if low Vitamin D - many studies 15+ studies
- Post-partum depression and low Vitamin D - many studies 15+ studies
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Most were taking 2,000 to 7,000 IU daily for >50% of pregnancy
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ReducesEvidence 0. Chance of not conceiving 3.4 times Observe 1. Miscarriage 2.5 times Observe 2. Pre-eclampsia 3.6 times RCT 3. Gestational Diabetes 3 times RCT 4. Good 2nd trimester sleep quality 3.5 times Observe 5. Premature birth 2 times RCT 6. C-section - unplanned 1.6 times Observe Stillbirth - OMEGA-3 4 times RCT - Omega-3 7. Depression AFTER pregnancy 1.4 times RCT 8. Small for Gestational Age 1.6 times meta-analysis 9. Infant height, weight, head size
within normal limitsRCT 10. Childhood Wheezing 1.3 times RCT 11. Additional child is Autistic 4 times Intervention 12.Young adult Multiple Sclerosis 1.9 times Observe 13. Preeclampsia in young adult 3.5 times RCT 14. Good motor skills @ age 3 1.4 times Observe 15. Childhood Mite allergy 5 times RCT 16. Childhood Respiratory Tract visits 2.5 times RCT RCT = Randomized Controlled Trial
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