Assessing the Impact of Vitamin D Supplementation on Respiratory Infections in Children and Adolescents: A Cross-Sectional Study
Nutrients 2024, 16(22), 3953; https://doi.org/10.3390/nu16223953
by Elena Tanase 1,Larisa Mihaela Marusca 1,2,*,Florin George Horhat 3ORCID,Monica Susan 4,Razvan Susan 5ORCID,Razvan Horhat 6ORCID,Stefania Dinu 7ORCID,Tiberiu-Liviu Dragomir 8 and Sonia Tanasescu 9 Romania
Background and Objectives: Recent studies suggest that vitamin D supplementation and higher serum 25-hydroxyvitamin D (25-OHD) concentrations may reduce the incidence of respiratory infections in children and adolescents. This cross-sectional study aimed to evaluate the association between different concentrations of vitamin D supplementation, serum 25-OHD concentrations, and the frequency of respiratory infections among individuals aged 1 to 18 years, for a duration of 2 years.
Methods: Concerning sun exposure in relation to vitamin D, the study took place in Romania, at approximately 45-degree northern latitude. A total of 194 patients were divided into groups based on weekly vitamin D supplementation (<400 IU, 400–800 IU, >800 IU), serum 25-OHD concentrations (<20 ng/mL, 20–30 ng/mL, >30 ng/mL), and age (<6 years, 6–12 years, 12–18 years). The overall incidence of respiratory infections was 41.2%.
Results: Participants receiving >800 IU/week had a significantly lower incidence of infections (16.7%) compared to those receiving <400 IU/week (60.0%, p < 0.001). Similarly, participants with serum 25-OHD concentrations >30 ng/mL had an infection rate of 16.7%, compared to 61.4% in those with concentrations <20 ng/mL (p < 0.001). Age-specific analyses revealed that the protective effect of vitamin D was most pronounced in children under 6 years old. Logistic regression showed that higher vitamin D supplementation and serum 25-OHD concentrations were independently associated with reduced odds of respiratory infections (OR = 0.25 and OR = 0.22, respectively, p < 0.001).
Conclusions: These findings support the potential role of vitamin D supplementation in preventing respiratory infections in the pediatric population.
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27+ VitaminDWiki Infant-Child pages with RESPIRATORY OR RTI in title
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Items found: 27
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3X reduction in respiratory infections in children taking more than 800 IU of Vitamin D weekly – Nov 2024 |
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21 Nov, 2024 |
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Infant respiratory distress reduced by Vitamin D – meta-analysis July 2024 |
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03 Aug, 2024 |
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2X less risk of respiratory distress syndrome if 50,000 IU of Vitamin D just before premature birth – RCT May 2024 |
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18 May, 2024 |
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COVID Vaccinated Children 1.25 X More Likely to Be Hospitalized for Respiratory Illness - CDC Jan 2024 |
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12 Jan, 2024 |
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Respiratory infection, children and Vitamin D - many studies |
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08 Oct, 2023 |
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Respiratory infections in children 6 X more likely if low Vitamin D (avg of 2 studies) - Aug 2023 |
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22 Aug, 2023 |
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3% fewer respiratory problems in children if single 100K vitamin D in 3rd trimester – May 2023 |
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27 May, 2023 |
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Cost-effective to give Vitamin D to all children to prevent acute respiratory infection – April 2023 |
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09 Apr, 2023 |
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Respiratory viral infection (RSV) and low vitamin D - many studies |
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18 Nov, 2022 |
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2.4 X fewer lower respiratory track infections in infants getting 400 IU of Vitamin D – May 2022 |
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24 May, 2022 |
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Infant Respiratory Infections not reduced by mothers taking small amount of vitamin D (28,000 weekly)– RCT July 2021 |
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03 Jul, 2021 |
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Recurrent RTI treatment success: Conventional 71 pcnt, Vitamin D 96 pcnt – March 2021 |
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12 Apr, 2021 |
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Preemie Respiratory Distress Syndrome is 5X more likely if low vitamin D – Dec 2020 |
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18 Dec, 2020 |
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Lower Respiratory Tract Infection in Infants reduced 5.9 X by daily 600 IU of vitamin D (China) - March 2020 |
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07 Mar, 2020 |
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No preemie had even 30 ng of vitamin D, lower D associated with more Respiratory Distress – Aug 2013 |
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24 Jul, 2019 |
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Respiratory Distress Syndrome in preemies 5 X more likely if poor vitamin D receptor – Feb 2019 |
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15 Feb, 2019 |
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Childhood Respiratory Health hardly improved with 600 IU of vitamin D (need much more) – May 2018 |
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28 May, 2018 |
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Preemies with poor lungs (Respiratory distress syndrome) have low levels of vitamin D – Nov 2017 |
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14 Nov, 2017 |
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Respiratory infection in infant was 7 X more likely if low cord Vitamin D – March 2017 |
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28 Sep, 2017 |
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Acute Lower Respiratory Infections in Children - associated with low vitamin D – meta-analysis Dec 2014 |
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16 Sep, 2016 |
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Respiratory tract infections in childhood – vitamin D is needed, no consensus of how much – Oct 2015 |
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15 May, 2016 |
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Respiratory distress after preterm birth is more likely if low vitamin D – review April 2015 |
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05 Aug, 2015 |
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Low dose Vitamin D during pregnancy and infancy results in strange acute respiratory infection response – April 2015 |
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24 Mar, 2015 |
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Acute lower respiratory infection 5X more frequent with low vitamin D intake – June 2012 |
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20 Mar, 2015 |
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Newborn acute lower respiratory tract infection associated with low maternal vitamin D – March 2015 |
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20 Mar, 2015 |
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Respiratory Tract Infection visits 2.5 less likely with vitamin D: Pregnancy 2000 IU, Infant 800 IU – RCT Oct 2014 |
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04 Oct, 2014 |
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Largest cause of infant deaths is respiratory infections, which is associated with low vitamin D – April 2011 |
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23 Jun, 2013 |