Association of vitamin D status with hospital morbidity and mortality in adult hospitalized COVID-19 patients
Endocr Pract . 2021 Mar 8;S1530-891X(21)00057-4. doi: 10.1016/j.eprac.2021.02.013.
Nipith Charoenngam, MD; Arash Shirvani, MD, PhD; Niyoti Reddy, MBBS; Danica M. Vodopivec, MD; Caroline M. Apovian, MD; Michael F. Holick, MD
- It has been proposed that vitamin D is an immunomodulatory agent that is protective against severity of COVID-19.
- We found an independent association between serum 25-hydroxyvitamin D ≥30 ng/mL and decreased risk of mortality from COVID-19 in elderly patients and patients without obesity.
- It is advisable to maintain serum 25-hydroxyvitamin D at least 30 ng/mL to reduce the risk of developing severe COVID-19.
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As of Oct 20, 2021, the page had: 34 trials, 6 trial results, 27 meta-analyses and reviews, 64 observations, 35 recommendations, 55 associations, 89 speculations, 48 videos see related: Governments, HealthProblems, Hospitals, Dark Skins, 26 risk factors are ALL associated with low Vit D, Recent Virus pages Fight COVID-19 with 50K Vit D weekly Vaccines
- COVID-19 treated by Vitamin D (example: ICU reduced by 5X) – 20th meta-analysis Oct 13, 2021
- Severe COVID-19 2.5 X more likely if low vitamin D (23 studies) – 19th meta-analysis Oct 2021
- COVID-19 mortality extrapolates to zero at 50 ng of vitamin D – 18th Meta-analysis Sept 2021
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- COVID-19 mortality 3X more likely if low vitamin D (999,179 people) – meta-analysis March 29, 2021
- COVID-19 was 2.6X more severe if very low Vitamin D (43 studies) – meta-analysis March 26, 2021
- Low Vitamin D associated with 2.7X more severe COVID-19 – 12th MA March 5, 2021
- Vitamin D supplementation fights COVID-19 – 11th meta-analysis Jan 24, 2021
- 3.7 X less likely to die of COVID-19 if supplemented with Vitamin D - meta-analysis Jan 5, 2021
- Less likely to test positive for COVID-19 if higher Vitamin D – meta-analysis Jan 6, 2021
- Vitamin D reduces COVID-19 by 80 percent - anonymous meta-analysis - Jan 5, 2021
- COVID-19 1.7X more likely to be severe if low Vitamin D - meta-analysis Oct 2020
- Low Vitamin D associated 1.8X increased risk of COVID-19 death in hospital – meta-analysis Nov 4, 2020
- Acute viral respiratory infections (RTI) reduced by Vitamin D - 20 reviews - Aug 2020
- Prudent to consider that Vitamin D has a role in COVID-19 – meta-analysis – Aug 7, 2020
- Risk of enveloped virus infection is increased 50 percent if poor Vitamin D Receptor - meta-analysis Dec 2018
- Hepatitis B patients have 2 ng lower level of Vitamin D – meta-analysis June 2019
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Vitamin D, Zinc, etc. look promising for COVID-19 (Holick) – Jan 25, 2021
Call for immediate action - Fight COVID-19 with vitamin D (up to 4,000 IU) - Jan 28, 2021
Rate of COVID-19 test positive is 40 pcnt lower if high vitamin D (192,000 people) - Holick Sept 2020
To determine the association between vitamin D status and morbidity and mortality in adult hospitalized COVID-19 patients
We performed a retrospective chart review study in COVID-19 patients aged ≥18 years old hospitalized at Boston University Medical Center between March 1 – August 4, 2020. All studied patients were tested positive for COVID-19 and had serum levels of 25-hydroxyvitamin D results measured within one year prior to the date of positive tests. Medical information was retrieved from the electronic medical record and were analyzed to determine the association between vitamin D status and hospital morbidity and mortality.
Among the 287 patients, 100 (36%) patients were vitamin D-sufficient [25(OH)D >30 ng/mL] and 41 (14%) patients died during the hospitalization. Multivariate analysis in patients aged ≥65 years old revealed that
- vitamin D sufficiency [25(OH)D ≥30 ng/mL] was statistically significantly associated
- with decreased odds of death (adjusted OR 0.33, 95%CI, 0.12–0.94),
- acute respiratory distress syndrome (adjusted OR 0.22, 95%CI, 0.05–0.96), and
- severe sepsis/septic shock (adjusted OR 0.26, 95%CI, 0.08–0.88),
after adjustement for potential confounders.
Among patients with body mass index <30 kg/m 2, vitamin D sufficiency was statistically significantly associated with a decreased odds of death (adjusted OR 0.18, 95%CI, 0.04–0.84). No significant association was found in the subgroups of patients aged <65 years old or BMI ≥30 kg/m 2.
We revealed an independent association between vitamin D sufficiency defined by serum 25(OH)D ≥30 ng/mL and decreased risk of mortality from COVID-19 in elderly patients and patients without obesity.