Toggle Health Problems and D

300,000 IU of vitamin D2 reduced inflammation markers (cytokines and chemokines) – Sept 2013

The relationship between pro-resorptive inflammatory cytokines and the effect of high dose vitamin D supplementation on their circulating concentrations.

Int Immunopharmacol. 2013 Sep 2. pii: S1567-5769(13)00331-7. doi: 10.1016/j.intimp.2013.08.010.
Karim Y, Turner C, Dalton N, Roplekar R, Sankaralingam A, Ewang M, Fogelman I, Hampson G.
Department of Immunology, St Thomas' Hospital, London SE1 7EH, UK.

Inflammatory/pro-resorptive cytokines and chemokines form part of a complex inter-dependent network and may be influenced by vitamin D. We investigated their inter-relationship and the effect of a loading dose of vitamin D. We measured plasma concentrations of an array of cytokines including tumour necrosis factor-alpha (TNF-α), interleukin-1 (IL-1), IL-6, IL-17, IL-8, granulocyte macrophage colony stimulating factor (GM-CSF), and the chemokine monocyte chemoattractant protein-1 (MCP-1). Cytokines, 25 (OH) vitamin D, 1,25 (OH)2 vitamin D, the Wnt inhibitor, DKK1 concentrations and bone turnover markers were measured at baseline and 3months following a bolus dose (300,000IU) of vitamin D2 in 39 subjects with vitamin D insufficiency.
We observed strong correlations between

  • TNF-α with GM-CSF (r=0.628, p<0.001),
  • IL-17 (r=0.7, p<0.001) and
  • MCP-1 (r=0.5, p=0.001),
  • between IL-1β with IL-17 (r=0.45, p=0.004) and
  • between the 2 chemokines, IL-8 and MCP-1 (r=0.45, p=0.004).

A positive correlation was seen between DKK1 and IL-1β (r=0.35, p=-0.029). Following vitamin D loading at 3months, the relationships between some of the cytokines changed (TNF-α and MCP-1: r=0.38, p=0.017, IL-1β and IL-17: r=0.3, p=0.06). 1,25 (OH)2 vitamin D increased markedly following supplementation. Significant correlations were seen between 25 (OH) vitamin D (r=0.4 p=0.016) and 1,25 (OH)2 vitamin D (r=0.39 p=0.02) with plasma CTX (marker of bone resorption) at 3months. TNF-α and IL-1β increased significantly at 3months (p<0.05). The close association between several cytokines is influenced by vitamin D status. Acute increases in 1,25 (OH)2 vitamin D, achieved with loading doses of vitamin D, lead to increases in pro-resorptive cytokines.

PMID: 24007780

Much better would have been to use several smaller doses of Vitamin D3, which lasts longer and is better

See any problem with this page? Report it (WORKS NOV 2021)