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300,000 IU of vitamin D injection not enough to statistically reduce markers of Venous Thromboembolism – RCT July 2016

The Effect of High-Dose Vitamin D3 on Soluble P-Selectin and hs-CRP Level in Patients With Venous Thromboembolism: A Randomized Clinical Trial.

Clin Appl Thromb Hemost. 2016 Jul;22(5):483-9. doi: 10.1177/1076029614568715. Epub 2015 Jan 19.
Gholami K1, Talasaz AH2, Entezari-Maleki T3, Salarifar M4, Hadjibabaie M1, Javadi MR1, Dousti S5, Hamishehkar H6, Maleki S7.


VitaminDWiki suspects that significant results would have resulted from any of:

  • A single dose of 500,000 IU
  • two doses of 300,000 IU
  • Oral dosing of 500,000 over a space of 2 months

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 Download the PDF from VitaminDWiki
High plasma level of P-selectin is associated with the development of venous thromboembolism (VTE). Furthermore, supplementation of vitamin D could decrease thrombotic events. Hence, this study was designed to examine whether the administration of vitamin D can influence the plasma level of P-selectin in patients with VTE. In the randomized controlled trial, 60 patients with confirmed acute deep vein thrombosis and/or pulmonary embolism (PE) were randomized into the intervention (n = 20) and control (n = 40) groups.
The intervention arm was given an intramuscular single dose of 300 000 IU vitamin D3 Plasma level of 25-hydroxy vitamin D, P-selectin, and high-sensitive C-reactive protein (hs-CRP) was measured at baseline and 4 weeks after. The plasma level of P-selectin (95% confidence interval = -5.99 to -1.63, P = .022) and hs-CRP (P = .024) significantly declined in vitamin D-treated group, while only hs-CRP was significantly decreased in the control group (P = .011). However, the magnitude of these reductions was not statistically significant. This study could not support the potential benefit of the high-dose vitamin D on plasma level of P-selectin and hs-CRP in patients with VTE.

PMID: 25601896 DOI: 10.1177/1076029614568715

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7725 VT.jpg admin 28 Jan, 2017 17:10 45.76 Kb 513
7724 VT.pdf PDF 2016 admin 28 Jan, 2017 17:09 173.56 Kb 450
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