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3 to 6 months to plateau with 4,000 IU vitamin D daily (Cardiac Patients) – June 2017

Effects of Vitamin D on Cardiac Function in Patients With Chronic HF: The VINDICATE Study.

J Am Coll Cardiol. 2016 Jun 7;67(22):2593-603. doi: 10.1016/j.jacc.2016.03.508.
Witte KK1, Byrom R2, Gierula J2, Paton MF2, Jamil HA2, Lowry JE2, Gillott RG3, Barnes SA3, Chumun H2, Kearney LC2, Greenwood JP2, Plein S2, Law GR2, Pavitt S4, Barth JH5, Cubbon RM2, Kearney MT2.
3 to 6 Months to plateau VDW# 8501

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Nutrition: US recommendations fail to correct vitamin D deficiency
From Heaney 2003

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Patients with chronic heart failure (HF) secondary to left ventricular systolic dysfunction (LVSD) are frequently deficient in vitamin D. Low vitamin D levels are associated with a worse prognosis.

The VINDICATE (VitamIN D treatIng patients with Chronic heArT failurE) study was undertaken to establish safety and efficacy of high-dose 25 (OH) vitamin D3 (cholecalciferol) supplementation in patients with chronic HF due to LVSD.

We enrolled 229 patients (179 men) with chronic HF due to LVSD and vitamin D deficiency (cholecalciferol <50 nmol/l [<20 ng/ml]). Participants were allocated to 1 year of vitamin D3 supplementation (4,000 IU [100 μg] daily) or matching non-calcium-based placebo. The primary endpoint was change in 6-minute walk distance between baseline and 12 months. Secondary endpoints included change in LV ejection fraction at 1 year, and safety measures of renal function and serum calcium concentration assessed every 3 months.

One year of high-dose vitamin D3 supplementation did not improve 6-min walk distance at 1 year, but was associated with a significant improvement in cardiac function (LV ejection fraction +6.07% [95% confidence interval (CI): 3.20 to 8.95; p < 0.0001]); and a reversal of LV remodeling (LV end diastolic diameter -2.49 mm [95% CI: -4.09 to -0.90; p = 0.002] and LV end systolic diameter -2.09 mm [95% CI: -4.11 to -0.06 p = 0.043]).

One year of 100 μg daily vitamin D3 supplementation does not improve 6-min walk distance but has beneficial effects on LV structure and function in patients on contemporary optimal medical therapy. Further studies are necessary to determine whether these translate to improvements in outcomes. (VitamIN D Treating patIents With Chronic heArT failurE [VINDICATE]; NCT01619891).

Created by admin. Last Modification: Tuesday July 16, 2019 20:59:55 GMT-0000 by admin. (Version 21)

Attached files

ID Name Comment Uploaded Size Downloads
8094 Heaney 2003.pdf PDF admin 11 Jun, 2017 00:42 176.13 Kb 650
8092 Chronic HF 4000 IU daily.pdf PDF 2017 admin 10 Jun, 2017 17:12 1.05 Mb 736