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21 fewer days in hospital with ARDS (COVID) if 10,000 IU of Vitamin D daily after enter hospital – RCT April, 2022


Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D

Biomedicine & Pharmacotherapy https://doi.org/10.1016/j.biopha.2022.112965
Montserrat Torres, Guiomar Casado, Lorena Vigón, Sara Rodríguez-Mora, Elena Mateos, Fernando Ramos-Martín, Daniel López-Wolf, José Sanz-Moreno, Pablo Ryan-Murua, María Luisa Taboada-Martínez, María Rosa López-Huertas, Miguel Cervero, Mayte Coiras – Multidisciplinary Group of Study of COVID-19 (MGS-COVID)1 Madrid

Highlights

  • Treatment with 10,000 IU/day of cholecalciferol was safe during severe COVID-19.
  • Anti-inflammatory cytokine IL-10 was significantly increased in 10,000 IU/day group.
  • Individuals who received 10,000 IU/day of cholecalciferol showed increased CD4 count.
  • Individuals with ARDS in 10,000 IU/day group stayed at the hospital less time.
  • The 10,000 IU/day group showed increased antiviral cytotoxic activity.

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Main cause of severe illness and death in COVID-19 patients appears to be an excessive but ineffectual inflammatory immune response that may cause severe acute respiratory distress syndrome (ARDS). Vitamin D may favour an anti-inflammatory environment and improve cytotoxic response against some infectious diseases. A multicenter, single-blind, prospective, randomized clinical trial was approved in patients with COVID-19 pneumonia and levels of 25-hydroxyvitamin D (25(OH)D) of 14.8 ng/mL (SD: 6.18) to test antiviral efficacy, tolerance and safety of 10,000 IU/day of cholecalciferol (vitamin D3) for 14 days, in comparison with 2,000 IU/day.
After supplementation, mean serum 25(OH)D levels increased to

  • 19 ng/mL on average in 2,000 IU/day versus
  • 29 ng/mL in 10,000 IU/day group (p <0.0001).

Although levels of inflammatory cytokines were not modified by treatment with 10,000 IU/day, there was an increase of anti-inflammatory cytokine IL-10 and higher levels of CD4+ T cells, with predominance of T central memory subpopulation.
Cytotoxic response against pseudotyped SARS-CoV-2 infected cells was increased more than 4-fold in patients who received 10,000 IU/day. Moreover, levels of IFN? were significantly higher in this group.

Beneficial effect of supplementation with 10,000 IU/day was also observed in participants who developed ARDS and stayed at the hospital for 8.0 days, whereas those who received 2,000 IU/day stayed for 29.2 days (p=0.0381). Administration of high doses of vitamin D3 as adjuvant of the standard care treatment during hospitalization for COVID-19 may improve the inflammatory environment and cytotoxic response against pseudotyped SARS-CoV-2 infected cells, shortening the hospital stay and, possibly, improving the prognosis.
 Download the PDF from VitaminDWiki

Graphical summary
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Clipped from PDF
The inclusion criteria for the participants in the study were being adults (>18 years old) hospitalized for at least seven days from the onset of COVID-19 symptoms, which is when usually began the inflammatory phase, with a diagnosis of pneumonia due to COVID-19

Speculation:
No hospitalization if had gotten high dose vitamin D at COVID symptom onset

VitaminDWiki: Take lots of Vitamin D at first signs of COVID

thanks to Gustavo Bellini for pointing out this study


VitaminDwiki- Items in both categories Virus and Intervention (40 items)

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VitaminDWiki – COVID-19 treated by Vitamin D - studies, reports, videos

As of Nov 25, 2022, the VitaminDWiki COVID page had:  19 trial results,   37 meta-analyses and reviews,   Mortality studies   see related:   Governments,   HealthProblems,   Hospitals,  Dark Skins,   26 risk factors are ALL associated with low Vit D,   Recent Virus pages   Fight COVID-19 with 50K Vit D weekly   Vaccines   Take lots of Vitamin D at first signs of COVID   116 COVID Clinical Trials using Vitamin D (08/2022)
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VitaminDWiki pages with HIGH-DOSE in title (63 as of April 2022)

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Items found: 67
Title Modified
Many diseases treated by high-dose Vitamin D 04 Dec, 2022
Muscular Dystrophy and high-dose Vitamin D 03 Dec, 2022
High dose vitamin D fights Folate gene changes by COVID, autoimmune, CVD, ALZ – Oct 2022 06 Oct, 2022
Treat COVID with early high-dose Vitamin D (20th as of June 2022) 16 Jun, 2022
High-Dose Vitamin D puts surplus calories into muscles instead of fat (mice) – May 2022 20 May, 2022
Comparing High-dose vitamin D therapies 04 May, 2022
High-dose Vitamin D safe for children (10,000 IU daily, 600,000 IU bolus) – meta-analysis April 2022 15 Apr, 2022
Coimbra protocol using high-dose Vitamin D is safe – April 2022 10 Apr, 2022
Several rheumatic diseases treated by high-dose vitamin D, but made worse if Calcium was added – April 2022 28 Mar, 2022
Cluster headaches virtually eliminated in 7,000 people with high-dose vitamin D and cofactors - Feb 2022 25 Feb, 2022
Cluster Headaches treated by high-dose Vitamin D, etc. (interview and transcript) - Feb 2022 23 Feb, 2022
Beyond vitamin D - book of testimonials on high-dose Coimbra Protocol - Aug, 2021 16 Feb, 2022
High-Dose Vitamin D Therapy – book July 2018 11 Feb, 2022
High-dose Vitamin D is safe and effective – review of 10 studies – Sept 2021 08 Feb, 2022
HIV treatment augmented by high-dose vitamin D, daily or weekly – Dec 2021 30 Jan, 2022
High-dose Omega-3 fought COVID in 2 hospital trials (6x reduction in ICU, reduced time) – Masterjohn Oct 2021 14 Oct, 2021
Multiple Sclerosis treated by Vitamin D, recommends investigating high dose Coimbra - Oct 2021 07 Oct, 2021
Those getting high dose vitamin D were 7 X less likely to die of COVID-19 - Dec 11, 2020 30 Sep, 2021
Vitamin D3 better than D2, especially if non-daily or high dose - meta-analysis Sept 2021 23 Sep, 2021
High-dose vitamin D improves health (presentation) - Aug 30, 2021 30 Aug, 2021
High dose vitamin D for Autoimmune diseases - Portuguese - 2019 01 Jul, 2021
High Dose Vitamin D for autoimmune diseases -blog June 13, 2021 20 Jun, 2021
Some pathogens and health problems restrict Vitamin D from being used – Coimbra high-dose protocol – April 2021 26 Apr, 2021
Kidney patients who happened to be getting high-dose Calcitriol were 9X less likely to die of COVID-19 - April 6, 2021 13 Apr, 2021
Autoimmune and high-dose vitamin D (Dr. Coimbra) - Dr. Mahtani video and transcript - Nov 2020 11 Apr, 2021
Vitamin D Resistance hypothesis confirmed by Coimbra high-dose vitamin D protocol – April 2021 11 Apr, 2021
Crohn’s Disease reduced for a year by 7 weeks of high dose Vitamin D – RCT March 2021 26 Mar, 2021
COVID-19 and high-dose Vitamin D - Video interview of Dr. Coimbra - May 2020 09 Aug, 2020
High doses vitamin D may prevent or treat COVID-19 - June 2020 31 Jul, 2020
Many doctors believe that high dose vitamin D can fight COVID-19 – BMJ April 2020 14 Apr, 2020
Lowering Calcium Risk when having High Dose Vitamin D3 – Cawley Dec 2019 18 Dec, 2019
The use of high dose Vitamin D (Coimbra Protocol) for multiple sclerosis in Germany – 2019 26 Nov, 2019
Cystic Fibrosis is safely treated by high-dose Vitamin D – Sept 2019 26 Nov, 2019
Rheumatoid Arthritis sometimes helped by very high dose vitamin D2 – 1935 29 Oct, 2019
High-dose Vitamin D for Multiple Sclerosis is OK while pregnant – Sept 2019 10 Sep, 2019
Cardiovascular Prevention with Omega-3 (finally using high doses) – Sept 2019 09 Sep, 2019
Treat autoimmune diseases with high-dose vitamin D – Germany online Aug 24, 25 2019 17 Aug, 2019
Successful high dose vitamin D (Coimbra Protocol) should be evaluated – June 2019 09 Jun, 2019
Hypertension gene expression reduced by high-dose vitamin D (hypertensive rats) – March 2019 27 Mar, 2019
High-dose vitamin D forum – for Multiple Sclerosis and many other diseases – Jan 2019 05 Jan, 2019
Vitamin D nanoemulsion corrected deficiency and improved bones in 1 week (high dose in rats) – Jan 2019 05 Jan, 2019
Multiple Sclerosis - Coimbra Protocol (high-dose Vitamin D) - by one of the 120 doctors of 20,000 patients - Dec 2018 08 Dec, 2018
Problem with vitamin C if high dose Vitamin D for MS and have gene problem – Sept 2018 10 Oct, 2018
Replies to doctor’s comments about high dose Vitamin D for Multiple Sclerosis– Nov 2016 27 Jun, 2018
Guide for patients on high doses of Vitamin D – Coimbra 2017 21 Jun, 2018
Multiple Sclerosis treated when use high doses of vitamin D – meta-analysis May 2018 16 May, 2018
Liver cancer nicely treated by high dose vitamin D for 16 weeks (early stage, in rats) – April 2018 23 Apr, 2018
Gene activation by high dose vitamin D - both quick and long term - April 2015 27 Jun, 2017
ICU cost reduced by at least 27,000 dollars if get high dose vitamin D in first week - April 2017 02 May, 2017
High dose vitamin D to treat Multiple Sclerosis etc. – protocol April 2017 27 Apr, 2017
High dose Omega-3 probably reduces heart problems – American Heart Association – March 2017 18 Mar, 2017
Video by Dr. Coimbra – 95 percent of auto-immune cured with vitamin D in high doses - April 2014 15 Jan, 2017
Caution When Prescribing High Dose Vitamin D (100,000 IU D2 daily for is too much after 4 years) – Nov 2016 26 Nov, 2016
Hospital ICU added high dose vitamin D - malpractice lawsuit costs dropped from 26 million dollars to ZERO - Oct 2016 20 Nov, 2016
70 percent of people with IBS had symptoms relieved with high dose vitamin D – 2012 04 Nov, 2016
Pediatric trials of high dose vitamin D -163 are in a single online database – Feb 2016 07 Aug, 2016
Kidney disease helped by active or high dose Vitamin D - Feb 2014 28 Apr, 2016
Dr. Coimbra explains his treatment with high dose vitamin D for multiple sclerosis – Feb 2015 27 Apr, 2016
High dose vitamin D (20,000 IU per kg) safe for pigs – Aug 2015 08 Aug, 2015
High dose vitamin reduced pain of fibromyalgia, osteoarthritis, and rheumatoid arthritis - July 2015 11 Jul, 2015
Brazillian petition to permit high vitamin D doses for autoimune diseases – Aug 2014 08 Feb, 2015
Update on Treating Multiple Sclerosis with high dose vitamin D - Sept 2013 08 Feb, 2015
Video by Dr. Coimbra – auto-immune cures with high-dose vitamin D in Brazil - April 2014 19 Apr, 2014
Response to high dose vitamin D is limited by vitamin A - July 2013 13 Apr, 2014
Liverpool is starting universal supplementation and needs high dose vitamin D – March 2014 26 Feb, 2014
4 clinical trials not find change in disease risk markers with high dose vitamin D – March 2013 13 Apr, 2013
Is High Dose Vitamin D Harmful – Dec 2012 20 Dec, 2012

Created by admin. Last Modification: Monday April 18, 2022 16:19:10 GMT-0000 by admin. (Version 11)

Attached files

ID Name Comment Uploaded Size Downloads
17452 10,000 IU summary.jpg admin 18 Apr, 2022 15:12 303.06 Kb 162
17451 ARDS days.jpg admin 18 Apr, 2022 15:12 25.80 Kb 224
17450 10,000 IU response.jpg admin 18 Apr, 2022 15:12 17.10 Kb 161
17449 Changes in the immune response 10,000 IU.pdf PDF 2022 admin 18 Apr, 2022 15:11 1.44 Mb 78
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