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2000 IU raised vitamin D levels of thin teens by 10 ng, obese teens by 6 ng – Oct 2012

Response to Vitamin D(3) Supplementation in Obese and Non-Obese Caucasian Adolescents.

Horm Res Paediatr. 2012 Oct 31.
Aguirre Castaneda R, Nader N, Weaver A, Singh R, Kumar S.
Division of Pediatric Endocrinology and Metabolism, Mayo Clinic College of Medicine, Rochester, Minn., USA.

Background/Aims: Vitamin D deficiency is highly prevalent in obese children, and obese children tend to respond poorly to vitamin D supplementation. The objective of the study was to compare the response to vitamin D(3) supplementation (2,000 IU once daily for 12 weeks) between obese and non-obese Caucasian adolescents.

Methods: The study design was open label non-randomized. It was carried out at a single center.

Eighteen obese adolescents (aged 12-18 years) and the same number of age-, gender- and season-matched non-obese adolescents received vitamin D(3) (2,000 IU/day) orally for 12 weeks. Total serum 25-hydroxyvitamin D [25(OH)D], parathyroid hormone, calcium and phosphorus were measured at baseline and at the end of the 12-week period.

Results: The mean baseline 25(OH)D level was higher in the non-obese compared to the obese subjects (mean 28.9 vs. 25.2 ng/ml; p = 0.029). The increment in 25(OH)D levels following vitamin D supplementation was significantly lower in the obese adolescents (mean change 5.8 vs. 9.8 ng/ml; p = 0.019).

Conclusions: Higher doses of vitamin D are required to treat vitamin D deficiency in obese adolescents compared to their non-obese peers.

Copyright © 2012 S. Karger AG, Basel. PMID: 23128469
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