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1700 IU vitamin D for a year provided no cardiovascular benefit (no surprise) – RCT Oct 2014

PLOS ONE 10.1371/journal.pone.0110476
Mazliza Ramly, Moy Foong Ming, Karuthan Chinna, Suhaili Suboh, Rokiah Pendek

VitaminDWiki Summary

Actually used 50,000 IU of vitamin D monthly
Vitamin D levels 12 ng ==> 34 ng
Quality of life increased slightly
Mental score increased slightly
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References include: Vitamin D fortification of vegetable oil A review of vitamin D fortification: implications for nutrition programming in Southeast. Asia. Food Nutr Bull 34: S81–89. (2013)
 Download the PDF from VitaminDWiki.

Many observational studies linked vitamin D to cardiometabolic risks besides its pivotal role in musculoskeletal diseases, but evidence from trials is lacking and inconsistent.

To determine whether Vitamin D supplementation in urban premenopausal women with vitamin D deficiency can improve cardiometabolic risks and health-related quality of life (HRQOL).

A double-blind randomized controlled trial was conducted in Kuala Lumpur, Malaysia. A total of 192 vitamin D deficient (<50 nmol/l) premenopausal women were randomized to receive either vitamin D 50,000 IU or placebo once a week for 2 months and then monthly for 10 months. Primary outcomes were serum 25(OH)D, serum lipid profiles, blood pressure and HOMA-IR measured at baseline, 6 months and 12 months. HRQOL was assessed with SF-36 at baseline and 12 months.

Ninety three and ninety-nine women were randomised into intervention and placebo groups respectively. After 12 months, there were significant differences in the serum 25(OH)D concentration (mean difference: 49.54; 95% CI: 43.94 to 55.14) nmol/l) and PTH levels (mean difference: −1.02; 95% CI: −1.67 to −0.38 pmol/l) in the intervention group compared to placebo group. There was significant difference between treatment group in both serum 25(OH)D and PTH. There was no effect of supplementation on HOMA-IR, serum lipid profiles and blood pressure (all p>0.05) between two groups. There was a small but significant improvement in HRQOL in the components of vitality (mean difference: 5.041; 95% CI: 0.709 to 9.374) and mental component score (mean difference: 2.951; 95% CI: 0.573 to 5.329) in the intervention group compared to placebo group.

Large and less frequent dosage vitamin D supplementation was safe and effective in the achievement of vitamin D sufficiency. However, there was no improvement in measured cardiometabolic risk factors in premenopausal women. Conversely vitamin D supplementation improves some components of HRQOL.

Trial Registration: Australian New Zealand Clinical Trial Registry ACTRN12612000452897

Attached files

ID Name Comment Uploaded Size Downloads
4536 Vegitable oil - need at least 2000 IU vit D per 100 gram -2013.pdf PDF 2013 admin 01 Nov, 2014 12:20 132.90 Kb 1079
4535 50,000 IU monthly.pdf PDF 2014 admin 01 Nov, 2014 11:47 265.13 Kb 910