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14 X less likely to have severe COVID if previously had more than 40 ng level of Vitamin D – Feb 2022


Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness

PLoS One. 2022 Feb 3;17(2):e0263069. doi: 10.1371/journal.pone.0263069
Amiel A Dror 1 2, Nicole Morozov 3, Amani Daoud 1 2, Yoav Namir 2, Orly Yakir 4, Yair Shachar 1, Mark Lifshitz 5, Ella Segal 1 2, Lior Fisher 1 2, Matti Mizrachi 1 2, Netanel Eisenbach 1 2, Doaa Rayan 1 2, Maayan Gruber 1 2, Amir Bashkin 2 6, Edward Kaykov 2 7, Masad Barhoum 8, Michael Edelstein 2, Eyal Sela 1 2

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Objective: Studies have demonstrated a potential correlation between low vitamin D status and both an increased risk of infection with SARS-CoV-2 and poorer clinical outcomes. This retrospective study examines if, and to what degree, a relationship exists between pre-infection serum 25-hydroxyvitamin D (25(OH)D) level and disease severity and mortality due to SARS-CoV-2.

Participants: The records of individuals admitted between April 7th, 2020 and February 4th, 2021 to the Galilee Medical Center (GMC) in Nahariya, Israel, with positive polymerase chain reaction (PCR) tests for SARS-CoV-2 (COVID-19) were searched for historical 25(OH)D levels measured 14 to 730 days prior to the positive PCR test.

Design: Patients admitted to GMC with COVID-19 were categorized according to disease severity and level of 25(OH)D. An association between pre-infection 25(OH)D levels, divided between four categories (deficient, insufficient, adequate, and high-normal), and COVID-19 severity was ascertained utilizing a multivariable regression analysis. To isolate the possible influence of the sinusoidal pattern of seasonal 25(OH)D changes throughout the year, a cosinor model was used.

Results: Of 1176 patients admitted, 253 had records of a 25(OH)D level prior to COVID-19 infection. A lower vitamin D status was more common in patients with the severe or critical disease (<20 ng/mL [87.4%]) than in individuals with mild or moderate disease (<20 ng/mL [34.3%] p < 0.001). Patients with vitamin D deficiency (<20 ng/mL) were 14 times more likely to have severe or critical disease than patients with 25(OH)D ≥40 ng/mL (odds ratio [OR], 14; 95% confidence interval [CI], 4 to 51; p < 0.001).

Conclusions: Among hospitalized COVID-19 patients, pre-infection deficiency of vitamin D was associated with increased disease severity and mortality.
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"We did not have access to data regarding whether patients had been treated for vitamin D deficiency."


Dr. Campbell video overview of the study - March 3, 2022

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Ivor Cummins review of the study

Wow - the Latest Vitamin D Study is Kinda Stunning! *Viral Revelations*
one of many graphics in his video
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Created by admin. Last Modification: Monday March 14, 2022 15:24:08 GMT-0000 by admin. (Version 10)

Attached files

ID Name Comment Uploaded Size Downloads
17186 Ivor.jpg admin 11 Mar, 2022 16:52 101.97 Kb 86
17002 Severity older than 65.jpg admin 04 Feb, 2022 02:03 35.62 Kb 380
17001 Severity 50-65.jpg admin 04 Feb, 2022 02:02 33.71 Kb 415
17000 14X table.jpg admin 04 Feb, 2022 02:02 90.50 Kb 544
16999 14X.pdf PDF 2022 admin 04 Feb, 2022 01:44 1.10 Mb 194
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