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100,000 IU of Vitamin D3 or D2 given monthly for 4 months to diabetics– RCT Dec 2019

Differential Effects of Oral Boluses of Vitamin D2 vs Vitamin D3 on Vitamin D Metabolism: A Randomized Controlled Trial

J of Clinical Endocrinology & Metabolism, Vol 104, #12, Dec 2019, Pages 5831–5839, https://doi.org/10.1210/jc.2019-00207
Adrian R Martineau, Kenneth E Thummel, Zhican Wang, David A Jolliffe, Barbara J Boucher, Simon J Griffin, Nita G Forouhi, Graham A Hitman
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VitaminDWiki

100,000 IU of Vitamin D3 OR D2 given orally to diabetics for 4 months
Apparently the Vitamin D measurement was made 1 month after the final dose - which is good
Diabetes

Diabetic response to Vitamin D is low: They need more or a different form

Vitamin D2 - why it is still used and studied?

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Context: Vitamin D2 and vitamin D3 have been hypothesized to exert differential effects on vitamin D metabolism.

Objective: To compare the influence of administering vitamin D2 vs vitamin D3 on metabolism of vitamin D3.

Methods
We measured baseline and 4-month serum concentrations of vitamin D3, 25-hydroxyvitamin D3 [25(OH)D3], 25-hydroxyvitamin D2, 24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3], 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3], and 4β,25-dihydroxyvitamin D3 [4β,25(OH)2D3] in 52 adults randomized to receive a total of four oral bolus doses of 2.5 mg vitamin D2 (n = 28) or vitamin D3 (n = 24) over four months. Metabolite-to-parent compound ratios were calculated to estimate hydroxylase activity. Pairwise before vs after comparisons were made to evaluate effects of vitamin D2 and vitamin D3 on metabolism of vitamin D. Mean postsupplementation metabolite-to-parent ratios were then compared between groups.

Results
Vitamin D2 was less effective than vitamin D3 in elevating total serum 25(OH)D concentration. Vitamin D2 suppressed mean four-month serum concentrations of 25(OH)D3, 24R,25(OH)2D3, 1α,25(OH)2D3, and 4β,25(OH)2D3 and mean ratios of 25(OH)D3 to D3 and 1α,25(OH)2D3 to 25(OH)D3, while increasing the mean ratio of 24R,25(OH)2D3 to 25(OH)D3. Vitamin D3 increased mean four-month serum concentrations of 25(OH)D3, 24R,25(OH)2D3, 1α,25(OH)2D3, and 4β,25(OH)2D3 and the mean ratio of 24R,25(OH)2D3 to 25(OH)D3. Participants receiving vitamin D2 had lower mean postsupplementation ratios of 25(OH)D3 to vitamin D3 and 1α,25(OH)2D3 to 25(OH)D3 than those receiving vitamin D3. Mean postsupplementation ratios of 24R,25(OH)2D3 to 25(OH)D3 and 4β,25(OH)2D3 to 25(OH)D3 did not differ between groups.

Conclusions
Bolus-dose vitamin D2 is less effective than bolus-dose vitamin D3 in elevating total serum 25(OH)D concentration. Administration of vitamin D2 reduces 25-hydroxylation of vitamin D3 and 1-α hydroxylation of 25(OH)D3, while increasing 24R-hydroxylation of 25(OH)D3.


Created by admin. Last Modification: Friday December 27, 2019 03:31:04 GMT-0000 by admin. (Version 11)

Attached files

ID Name Comment Uploaded Size Downloads
13170 Monthly D3, D2.jpg admin 18 Dec, 2019 00:22 26.78 Kb 212
13169 Bolus D2 D3.pdf PDF 2019 admin 18 Dec, 2019 00:22 1.12 Mb 98
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