Vitamin D deficiency and SARS-CoV-2 infection: Big-data analysis from March 2020 to March 2021. D-COVID study
Preprint doi: https://doi.org/10.1101/2022.10.27.514012
Methods: Using big-data analytics and artificial intelligence through the SAVANA Manager clinical platform, we analysed clinical data from patients with COVID-19 atended in a terciary university hospital from March 2020 to March 2021.
Results: Of the 143.157 analysed patients, 36.261 subjects had COVID-19 infection (25.33%); during this period; of these 2588 had vitamin D deficiency (7.14%). Among subjects with COVID-19 and vitamin D deficiency, there was a *higher proportion
- of women OR 1.45 [95% CI 1.33-1.57],
- adults older than 80 years OR 2.63 [95%CI 2.38-2.91],
- people living in nursing homes OR 2.88 [95%CI 2.95-3.45] and
- walking dependence OR 3.45 [95%CI 2.85-4.26].
Regarding clinical course, a higher number of subjects with COVID-19 and vitamin D deficiency
- required hospitalitation OR 2.41 [95%CI 2.22-2-61],
- intensive unit care (ICU) OR 2.22 [95% CI 1.64-3.02], had a
- longer mean hospital stay 3.94 (2.29) p=0.02 and
- higher mortality OR 1.82 95%CI 1.66-2.01.)
Conclusion: Low serum 25 (OH) Vitamin-D level was significantly associated with a worse clinical evolution and prognosis of COVID-19 infection. We found a higher proportion of institutionalised and dependent people over 80 years of age among patients with COVID-19 and vitamin D deficiency.
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