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Alzheimers-Cognition - Overview

Summary of Alzheimers and Vitamin D

Table of contents

Alzheimer's in VitaminDWiki

The items in both Cognition and Meta-analysis categories:

Cognition and Dementia in VitaminDWiki

Items in BOTH Cognition and Intervention categories

   give Vitamin D and look for improved cognition

200 patients nicely treated for all 3 types of Alzheimer's by adjusting several of 34 variables - Sept 2017

  • Variables include diet, exercise and supplements (no drugs, did not notice Vitamin D)
  • I would not normally have believed this claim except that it was described by Dr. Doidge, whom I trust after reading his book Missing Microbes
  • includes link to scienfic publication and new book

Alzheimer’s can also result from gene problems NOT detected by Vitamin D blood tests

Items in both Cognition and Vitamin D Receptor categories

Note above: Alzheimer’s 3 times more likely if poor VDR

Vitamin D Receptor category has the following

Genetics category listing contains the following

The first chart on this page untill Oct 2017 had been

The following chart triggered the creation of the chart at the top of this page


Note the assumption, which may be correct, that the immune system only responds to tissue Vitamin D, rather than from blood vitamin D

Immune modulation by Vitamin D, food allergy, chart of genes – July 2015 has the following chart
Genes and vitamin D  page 6748
All articles in both Pregnancy and Genetics:

Here are all 209 articles

Note: a software bug includes items from the subcategories of Vit D Receptor and Vit D Binding protein - sometimes 3 entries total

See also Vitamin D Binding Protein category listing has 83 items

In addition to inherited poor VDR genes, Herpes downregulates VDR by 8X for a short time

Note: Many people have Herpes but are not aware of it. (example: 48% of black women)

See also web

  • Natural Ways to Increase Calcitriol and Activate The Vitamin D Receptor Gene Selfhacked Jan 2016 - has lots of linked references
    Includes Exercise, RXR ( and retinol) is needed to produce proteins with the VDR, SIRT1 -potentiates VDR, PGC-1a, Dopamine
    Bile, Omega-3: Omega-6:Curcumin, Resveratrol, Forskolin , Gamma Tocotrienol, Estradiol,
    What Inhibits The Vitamin D Receptor (VDR) or Calcitriol
    Caffeine , Cortisol/Glucocorticoids, Prolactin, Thyroid hormones,Corticosteroids decrease calcitriol,Phosphatonin, Ketoconazole, Heparin and Thiazides decrease
    Pathogens That Inhibit The Vitamin D Receptor include
    P. aeruginosa, H. pylori, Lyme/Borrelia – Live Borrelia reduces VDR by 50 times (in monocytes).
    Tuberculosis – Reduces VDR 3.3-fold.“Gliding” biofilm bacteria, Shigella, Mycobacterium leprase
    Epstein-Barr virus (EBV) – Decreases VDR by a factor of about five, HIV – binds to the VDR (R) and inhibits conversion to active D
    Aspergillus fumigatus – In cystic fibrosis patients,
    Cytomegalovirus – CMV decreases VDR 2.2 fold, Hepatitis C virus – Inhibits CYP24A1|Changes in vitamin D endocrinology during aging in adults] June 2017
  • Changes in vitamin D endocrinology during aging in adults June 2017
  • "Aging leads to a decrease in vitamin D receptor number in several organs."
    Interesting, details are behind a paywall
  • Bioinformatic approaches to interrogating vitamin D receptor signaling - Sept 2017
    No such attachment on this page
  • Calcitriol receptor = VDR Wikipedia
    "Glucocorticoids are known to decrease expression of VDR,"
    "Mutations in this gene are associated with type II vitamin D-resistant rickets"
    "The vitamin D receptor plays an important role in regulating the hair cycle."


Light activates VDR at conception,etc. - April 2017
VDR gene methylation as a molecular adaption to light exposure: Historic, recent and genetic influences.
Am J Hum Biol. 2017 Apr 22. doi: 10.1002/ajhb.23010. [Epub ahead of print]
Beckett EL1,2,3, Jones P1, Veysey M2,4, Duesing K3, Martin C1, Furst J5, Yates Z6, Jablonski NG7, Chaplin G7, Lucock M1.
Eighty subjects were examined for VDR gene-CpG island methylation density. VDR gene variants were also examined by PCR-RFLP.
Duration of early-life light exposure and strength of recent irradiance, along with latitudinal genetic factors, influence degree of VDR gene methylation consistent with this epigenetic phenomenon being a molecular adaptation to variation in ambient light exposure. Findings contribute to our understanding of human biology.
Short URL = is.gd/VitDReceptor

Alzheimer’s disease – vitamin D looks promising – Annweiler Jan 2014 has a VDR chart

On the WEB

  • Alzheimer's summary at Vitamin D Council updated Dec 2015
  • 37 minute podcast Vitamin D and the brain Vitamin D Council Sept 2014
    discussion by Dr. Cannell and Dr. David Llewellyn
  • Cognitive Imparement Vitamin D Council update Sept 2017
  • Is Alzheimer’s Type 3 Diabetes? New York Times Sept 2012]
    Idea has been around since 2005. Brain cells become insulin resistant - first noticed by Dr. Alzheimer
    people with diabetes are at least twice as likely to get Alzheimer’s
  • PubMed Alzheimer's AND Insulin in title 299 items as of Dec 2017
    "Insulin Resistance and Alzheimer's Disease: Bioenergetic Linkages." Oct 2017 free PDF online
    "Insulin signaling: An opportunistic target to minify the risk of Alzheimer's disease." Sept 2017
    "Insulin resistance in Alzheimer's disease." May 2017
  • Vitamin D and neurology WikiPedia
    has sections on Dementia: Alzheimer's disease, Parkinson's disease, Multiple sclerosis, Epilepsy and seizures, Schizophrenia
  • Alzheimer's nutrient status - July 2014 includiing vitamin D - attached at the bottom of this page
  • Vitamin D Deficiency and Alzheimer Disease: Common Links July 2015, Publisher wants $40 for the PDF
    "Based on this accumulation of studies, we propose that VitD screening should be performed at least in those individuals at risk for VitD deficiency and AD"
  • Is It Alzheimer’s, or A.D.H.D.? New York Times Sept 2015
    3 % of Dutch over 60 have A.D.H. D. It overlaps with age-related cognitive decline
  • Probiotics improve cognition in Alzheimer's patients RCT Nov 2016
    Nothing about Vitamin D. 12 weeks of probiotics for Alzheimer's patients increased mental test score from 8.7 to 10.6 (max score = 30)
  • Should I Take The Gene Test For Alzheimer's? GreenMed Info. April 2017
    Yes:should have a gene test, especially if Alz runs in the family
    If you have two copies of APOE4 gene you cam be at 12X risk of getting Alzheimer's
    Personal note: I (Henry Lahore) have just one copu of the gene, so I have a 3X risk - the only gene risk from my 23andMe report
        Supplementing vitamin D, etc virtually eliminates my increased risk*6X increase in Age-Adjusted Death from Dementia (Finland) in 30 years
  • Age-adjusted = increase is NOT due to having a larger elderly population

_Dementia death rate - age standardized @is.gd/increasedisease

  • 6X increase in Age-Adjusted Death from Dementia (Finland) in 30 years
    Age-adjusted = increase is NOT due to having a larger elderly population

Dementia death rate - age standardized @is.gd/increasedisease

  • From Fight Aging On Increasing Your Chances of Avoiding Alzheimer's July 2011
    In many ways, Alzheimer's Disease looks a lot like type 2 diabetes - it can be argued that there are some biochemical similarities in the underlying mechanisms, Alzheimer's appears to be a lifestyle disease to some degree, and the two conditions have many of the same risk factors, such as obesity and being sedentary. So: "Over half of all Alzheimer's disease cases could potentially be prevented through lifestyle changes and treatment or prevention of chronic medical conditions. ...
    Analyzing data from studies around the world involving hundreds of thousands of participants, [researchers] concluded that worldwide, the biggest modifiable risk factors for Alzheimer's disease are, in descending order of magnitude, low education, smoking, physical inactivity, depression, mid-life hypertension, diabetes and mid-life obesity. ...

In the United States, [researchers] found that the biggest modifiable risk factors are

  • physical inactivity,
  • depression,
  • smoking,
  • mid-life hypertension,
  • mid-life obesity,
  • low education and
  • diabetes. ...

Note: EVERY SINGLE ONE of the above associations with Alzheimer's Disease is also associated with low vitamin D:

  • physical inactivity - not get out in the sun
  • depression category - a common result of low vitamin D:
  • Smoking - well known to consume vitamin D
  • mid-life hypertension a result of low vitamin D:
  • mid-life obesity - which results from low vitamin D, and Obesity makes vitamin D levels even lower
  • Low education - take far fewer nutritional supplements - due to cost, knowledge, belief
    • Note: low education is also associated with dark skinned people, who get less vitamin D from the sun
  • diabetes - a result of low vitamin D:

Clinical Trials underway for Cognition and Vitamin D INTERVENTION

Vitamin D, Cognition and Alzheimer's Disease: The Therapeutic Benefit is in the D-Tails - May 2016

J Alzheimers Dis. 2016 May 11;53(2):419-44. doi: 10.3233/JAD-150943.
Landel V1, Annweiler C2,3, Millet P1,4, Morello M1,5,6, Féron F1.
Fig. 2. Proposed mechanisms of vitamin D-mediated multitargeted effects in AD. Vitamin D imbalance is proposed to alter mechanisms implicated in aging and AD pathogenesis. Suggested protective effects of vitamin D supplementation concern regulation of vascular processes and oxidative stress, calcium homeostasis, neurotransmission, modulation of immune and inflammatory processes, and direct impact on amyloidogenesis, ultimately improving cognitive functions.

 Download the PDF from VitaminDWiki

Age-adjusted Death rates: Alzheimer's has been increasing the fastest


Big increase if both parents had Alzheimer's


54% of ALL people, of all ages, are now "touched" by Alzheimer's


Alzheimers Association facts and figures 2016 - nothing about vitamin D

 Download the PDF from VitaminDWiki
Has A LOT of information, including the following

  • "Compared with no TBI, moderate TBI is associated with twice the risk of developing Alzheimer’s and other dementias, and severe TBI with 4.5 times the risk"
  • "1 in 9 people over age 65 has Alzheimer's Disease"
  • "Among people aged 70, 61% of those with Alzheimer's Disease are expected to die before age 80 vs 30% of those without Alzheimers' "
  • "15 million Americans provide unpaid care for people with Alzheimer’s disease and other dementias."
  • "Total payments for Heatlh Care, Long term care, and Hospice are estimated to be $236 billion in 2016 for people with Alzheimer’s disease and other dementias."
    This $236 Billion does NOT include the costs due tor care-giving by family, lost time from work, etc.

Percentage Changes in Selected Causes of Death (All Ages) Between 2000 and 2013


Alzheimer's in more than half of hospital patients over age 65


Half of care-giving for 6+ years is due to Alzheimer's or other dementia


Work changes due to Alzheimer's or Dimentia care-giving


What if we could delay onset of Alzheimer's by 5 years - Alzheimer's Association - 2015

 Download the PDF from VitaminDWiki
Looks like about half of the people would not have Alzheimer's costs (die sooner?)

Cognition other than Vitamin D monotherapy

Magnesium and Mental Health  see  is.gd/VDMag

Items in BOTH Cognition and Omega-3 categories

APOE4 gene greatly increases risk of AD, but had been a benefit during childhood

The APOe4 gene protected our ancestors and helped them get through the child bearing years by attacking parasites and micro-organisms with oxidative stress. It is only in modern times that people live long enough for the same oxidative stress to work against us in old age.
A book, Survival of the Sickest,(2008) points out roughly the same concept in a number of other diseases which long ago helped our ancestors get through plagues, ice ages, parasites, famine, etc. It's a fascinating concept and it makes sense. By Rich H, Jan 2017
 Download the PDF of the book from VitaminDWiki

Small amount of Lithium slowed dementia in Alzheimer's

Rate of a rare form of early-onset Alzheimer's associated with Aluminium - 2017

Bill Gates put $50 million into Alzheimer's Research - Fall 2017 (no mention about Vitamin D)

  • Why I’m Digging Deep Into Alzheimer’s Bill Gates Blog
    "A person with Alzheimer’s or another form of dementia spends five times more every year out-of-pocket on healthcare than a senior without a neurodegenerative condition"
    For example, we don’t fully understand why you are more likely to get Alzheimer’s if you’re African American or Latino than if you’re white"
    VitaminDWiki suspects that the increased risk is due to lower levels of vitamin D in those with dark skins
  • Bill Gates' newest mission: Curing Alzheimer's CNN
    "Since 2002, there have been more than 400 Alzheimer drug trials run and yet no treatments"

Risk of Dementia reduced 50% by just using Brain Plasticity Software for just 13 hours - Nov 2017

Posit Science - 10 year experiment, full free text online
Speed of processing training results in lower risk of dementia


short url = http://is.gd/dcognition

The most recent items in category Seniors
The most recent items in category Overviews
The most recent items in category Parkinson
The most recent items in category Cognitive

Attached files

ID Name Comment Uploaded Size Downloads
9546 Dementia vs Alzheimer's.jpg admin 19 Mar, 2018 09:19 55.26 Kb 25
7796 ALZ Fig 2.jpg admin 05 Mar, 2017 22:00 21.45 Kb 3265
7795 Therapeutic Benefit is in the D-Tails.pdf PDF 2016 admin 05 Mar, 2017 21:59 523.25 Kb 298
7627 Survival Of The Sickest - 2008 book.pdf PDF admin 06 Jan, 2017 22:52 947.50 Kb 1264
7553 Lithium to the Rescue.pdf PDF 2016 admin 23 Dec, 2016 12:18 670.40 Kb 576
7407 Lithium as Nutrient - 2015.pdf PDF 2015 admin 29 Nov, 2016 11:40 128.16 Kb 511
7406 Lithium and Alz LEF Dec 2016.pdf PDF 2016 admin 28 Nov, 2016 23:56 3.40 Mb 556
7256 If delay onset by 5 years.jpg admin 29 Oct, 2016 14:54 15.97 Kb 2895
7255 Delay Alz by 5 years - 2015.pdf PDF 2015 admin 29 Oct, 2016 14:50 1,015.63 Kb 698
7254 Work changes due to Alz or Dimentia care-giving.jpg admin 29 Oct, 2016 14:12 19.54 Kb 3045
7253 Half of care giving for 6+ years is due to Alzheimer's or other dementia.jpg admin 29 Oct, 2016 14:06 38.45 Kb 2911
7252 Percentage Changes in Selected Causes of Death (All Ages) Between 2000 and 2013.jpg admin 29 Oct, 2016 00:04 21.84 Kb 3072
7251 Alz in more than half of hospital patients over age 65.jpg admin 28 Oct, 2016 23:46 37.59 Kb 3126
7250 Alzheimers Association facts and figures 2016.pdf PDF 2016 admin 28 Oct, 2016 23:45 2.07 Mb 669
7249 Alzheimer's dark skin.jpg admin 28 Oct, 2016 21:22 23.01 Kb 2048
7248 54% touched by Alzheimer's.jpg admin 28 Oct, 2016 21:21 23.94 Kb 3018
7247 Alzheimer's both parents.jpg admin 28 Oct, 2016 21:21 31.71 Kb 3236
4867 Dementia incidence.jpg admin 12 Jan, 2015 02:24 61.75 Kb 7845
4095 Alz nutrient status.pdf PDF 2014 admin 29 Jun, 2014 10:54 1.57 Mb 1416
3475 Death rates alzheimers.gif admin 02 Jan, 2014 17:37 38.58 Kb 14301
3469 Alzheimers percentage.png admin 29 Dec, 2013 11:57 49.40 Kb 25860
1131 Alzheimer\'s 2011.pdf PDF admin 04 Mar, 2012 15:28 1.09 Mb 1863
1130 Alz in hospital - 2011.jpg Go to hospital with Alz admin 04 Mar, 2012 15:24 34.72 Kb 9248
1129 Alz how long - 2011.jpg how long care needed admin 04 Mar, 2012 15:23 28.67 Kb 8890
1128 Alz F5 - 2011.jpg increases admin 04 Mar, 2012 15:23 20.73 Kb 9099
1120 Potential targets for Alz.jpg targets from D-Mentia admin 26 Feb, 2012 21:01 21.24 Kb 11334
1119 Vitamin D-mentia.pdf admin 26 Feb, 2012 21:00 292.71 Kb 2183
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